These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Accidental Aesop: McCloud comments that one of his friends said that the last issue's series-summing Aesop (fiction is good) sounds like it's advocating drug use.
Anvilicious: McCloud chides himself in the collection's commentary for the heavy-handed attack on racism in the story where Zot searches for crime in New York. What really pushes it over the top is the last panel, wherein Zot wonders if the South won the Civil War.
Crowning Moment of Heartwarming: When Terry wants to talk to Pam again and tell her about her feelings. Afraid, Terry walks toward her...but then keeps walking, ignoring Pam as she says hello. Downer Ending, cue letters page...and an extra page where Terry turns around yells "Pam!" The next panel shows her hurriedly rushing to Pam, sheepishly saying, "Hi!". He kept this in the omnibus for the powerful effect.