Audience-Alienating Premise: Generally, the series isn't held in high regards compared to other Spider-Man series as it viewed as putting Spider-Man in a situation that's un-Spider-Man-like, like putting him on another world.
Awesome Art: Say what you will about the show's writing, but nobody's complaining about the series' comic book-inspired visuals (which was planned to be used by a planned Captain America series for Fox the year before this show aired, but that got canned by Marvel going bankrupt — it's likely that producer Will Meuginot imported it).
Broken Base: A lot of fans weren't fond of the series because of how radical a departure it was from previous and subsequent Spider-Man adaptations, but there are some fans who see the show as a decent cartoon in its own right and having some interesting concepts.
Complete Monster: In the tie-in comic book to the animated series, the Chameleon is a monstrous Beastial capable of changing his appearance to those he has murdered. To use this to his advantage, Chameleon systematically stalks and murders over a dozen innocent people, then uses their identities to commit crimes. After being stopped by Spider-Man during a bank robbery that nearly leaves several people dead, Chameleon boasts his plans to ruin Spider-Man's name and crush the hope of his people by framing Spider-Man for the killings. Even in a world of dictators and monstrous symbiotes, the Chameleon stood out as a vile Serial Killer who disgusted Spider-Man more than any other villain he encountered.