These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Q·Ko-chan: The Earth Invader Girl
Designated Hero: Kirio. In general, Kirio is a jerkass who bullies his sick older sister Furiko and in the beginning treats Q·Ko like she was his personal toy, seeing the battles as fun. He gets better though.
The Woobie: Furiko. She thinks her mother does not love her, she is bullied by her younger brother Kirio, she has a heart disease and goes to the library so she won't have to be together with Kirio. This takes a bitter turn when she becomes AA·Ko's pilot. Then she becomes Woobie, Destroyer of Worlds.
Shiino also counts as this as she is a weak and shy girl whose best friend abandons her, her brother is sheltering a child alien, and her mother wants to move. Then she becomes the pilot of VV·Ko and may or may not have been used as ammo for a nuke.