!!!All comics:
* AlternateCharacterInterpretation:
** Several of the gym leaders, but Erika as a pot head takes the cake.
** N in White: Hard Mode is much worse than {{Canon}}; he's willing to ''kill'' Pokemon just to lecture their owners about how "this wouldn't have happened if you hadn't caught them!"
*** Speaking of, [[StrawmanHasAPoint with the message Team Plasma spreads in]] VideoGame/PokemonBlackAndWhite, interpretations go from them being a group of {{well intentioned extremist}}s, {{straw hypocrite}}s, {{anti villain}}s, or a mix of the three. How they interpret N is a whole different story.
** Given the large number of variations on the same stories, there's quite a bit of this within the spinoff comics as well. One of the more common interpretations in runs of [[VideoGame/PokemonRedAndBlue the first gen and its remakes]] is the common {{Fanon}} theory of Blue/Gary being Oak's [[TheUnfavorite Unfavorite]] while his grandfather favors the MC appears quite often. Other runs paint him as a flat-out {{Jerkass}}, while others split the difference for a JerkassWoobie.
** Another frequent point of variation: how gym leaders and other trainers respond to death on the battlefield. Any given gym leader could be portrayed as a professional who has accepted death as a natural consequence of battle, a friendly foe who's honestly shocked at seeing their opponent's pokemon die, or an utter {{Jerkass}} who gloats and rubs the loss in their face.
** [[VideoGame/PokemonRedAndBlue Professor Oak, Bill]], and [[VideoGame/PokemonRubyAndSapphire Mr. Briney]] are often portrayed as creepy perverts, as well.
** In ''almost any'' Ruby/Sapphire/Emerald run you read, Norman will be interpreted as a trainer who is so obsessed with Pokemon that he neglects spending time with his family.
** In the same vein, Archie is seldomly portrayed as anything more than [[StupidEvil a moron]]. Maxie has a few moments [[WhatAnIdiot ("How did I not see water is GOOD?!"),]] but he is generally shown as more intelligent and having [[AntiVillain greater thought out motives.]]
** Also in Hoenn runs, Wallace tends to be depicted as CampStraight and in a relationship with Winnona. This is probably influenced by ''Manga/PokemonSpecial''.
* ComplacentGamingSyndrome: Plagued with it to a degree. Despite the random nature of the game and how death can result in some odd teams, a ''lot'' of the comic makers tend to make similar choices of starter Pokemon and likely make similar choices on keeping mons if they are able to use them. A Johto locke that picks Chikorita tends up attract intrigue and curiosity since it is a rare occurrence while a Sinnoh locke that picks a Chimchar is regarded as another run-of-the-mill Nuzlocke.
** And most people are almost always going to get, the bug type, the rodent, the bird, and a zubat at some point. Just cause of how common they are.
* CrowningMomentOfAwesome: [[Awesome/NuzlockeComics Here]].
* CrowningMomentOfFunny: [[Funny/NuzlockeComics Here]].
* CrowningMomentOfHeartwarming: And [[Heartwarming/NuzlockeComics here]].
* MemeticMutation: The [[SelfImposedChallenge Nuzlocke Challenge rules]] have since then become ''very'' popular among players.
** "It's all happening for a reason."
* {{Shipping}}: In spinoffs, the MainCharacter with Pokemon Gym Leaders/NPC:
** A LOT of Nuzlockers seem to have waifu-time with their favorite Gym Leaders. Or, more recently, with [[MrFanservice N]]. Here's actually a few Nuzlockers who shipped ''rivals'' with Gym Leaders.
* RescuedFromTheScrappyHeap: A pretty normal occurrence in Nuzlocke runs. Due to the rules, players often end up having to use Pokemon they don't normally use, and consequently develop newfound respect and appreciation for them.
* StopHavingFunGuys: It is to be expected, given it is part of the Pokemon fandom, albeit rare. There are some who take the challenge [[SeriousBusiness rather seriously]] and will criticize the teambuilding of other players (if they are sharing the progress and results of their challenge) even though one of the premises of the challenge involves adapting to having no choice on what mons you can use outside of ones given as gifts.
* StrawmanHasAPoint: There's something to be said for N's claims -- that Pokemon battles are cruel, selfish, and only result in Pokemon being hurt -- on a normal playthrough. On a Nuzlocke run, he's pretty much right.
* TearJerker: Whenever a Pokemon dies. [[TearJerker/NuzlockeComics Deserves its own page...]]
* TheWoobie: Chances are you will come across a character who has suffered so many hardships, be it the loss of a friend, a crushing defeat, or even personal matters, that you can't help but want to hold them and comfort them.
* TheyWastedAPerfectlyGoodCharacter: Very often a new team member will be given an interesting and unique personality... only to be either permaboxed or quickly die to a random critical hit. Of course, this is sort of forced by AnyoneCanDie combined with RealLifeWritesThePlot.
* SlidingScaleofSillinessVersusSeriousness: The comics tend to vary from both extremes of this.
* {{Wangst}}: Once you apply FridgeLogic to the Nuzlocke comics.

!!!Original comic:
* BrokenBase: Episode 8 of White: Hard Mode has been getting this for [[spoiler: having Ruby catch Victini, showing the "No Legendaries" rule is not in effect]], resulting in either people okay with it (mostly due to the mon's personality) or crying "ruined" .
* GrowingTheBeard: The Ruby run was good, but rough around the edges. The Fire Red run saw a general improvement in the art, dialogue, characterization and plot, and was an even better series.
** And it seems like the White arc is starting to grow it even further, by having it in full color, the art being a lot more clean, and not overusing the ''Series/{{Lost}}'' references.
* HilariousInHindsight: In the Fire Red comic, Marowak's ghost is "defeated" in essentially the same way it is in ''Anime/PokemonOrigins''.
* HoYay: Bill and the guy with glasses.
* {{Squick}}/{{Fanservice}}: [[http://www.nuzlocke.com/wp-content/uploads/2010/03/ruby51.jpg Torkoal used Attract!]]
* NightmareFuel: [[http://www.nuzlocke.com/pokemonhardmode.php?p=27 Marowak's Ghost in this comic]], [[spoiler: Mewtwo's wall of Nuzlockers in the Fire Red run]], and as of White, N's [[DissonantSerenity Pidove.]] [[VerbalTic Coo.]]

!!!Hale's Emerald/Platinum Hard Mode:
* AlternateCharacterInterpretation: May goes from a FlatCharacter who didn't get as much characterization as Rival!Brandon to a StalkerWithACrush[=/=]{{Yandere}} whose expressions evoke ''VisualNovel/HigurashiWhenTheyCry''.
** Also in Emerald, Archie is a hippie, and Maxie is highly competent - he just wants to give land-dwellers a place to stay whenever Archie manages to flood the world.
** And then there's [[CreepyTwins Tate]] and [[{{Twincest}} Liza]]... even their Pokemon were freaked out.
** In Platinum, Stanley is an abusive boyfriend who tries to keep ShrinkingViolet Bern cowed.
* EnsembleDarkhorse: His depiction of May earned her an instant fanbase and DracoInLeatherPants status.
** BaseBreaker: Because of this though, she also developed a hateful VocalMinority, see ShipToShipCombat below. The inevitable FlameWar was so bad that eventually the comic had to be ''moved to another topic'' because of it.
** The run itself gained a lot of attention from the site as a whole, to the level that they filtered Nuzlocke into ''Hale''locke on the day of the Emerald Run's last update.
* HarsherInHindsight: In Hale's comic, Hale tells May that she should kill herself. [[spoiler: Guess what she tries to do later on.]]
** FunnyAneurysmMoment: May was treated as an IneffectualSympatheticVillain and her threats of murder aren't taken very seriously, even when she kills grandma Winstrait. [[spoiler: But then she finally manages to kill Django...]]
* HilariousInHindsight: [[http://i1.wp.com/hardycases.com/wp-content/uploads/2013/02/page12.jpg This]] strip has Hale hitting his Slugma and burning his hand as a throwaway gag. Fast-forward to VideoGame/PokemonXandY, and playing with Slugma in Pokemon Amie results in the same thing.
* ShipToShipCombat: Of a sort; the fight was between Hale/May and Hale/''nobody''.

!!! Apocalypse Johto:
* FridgeBrilliance: Giovanni is startled when [[spoiler: Candace disguised as a Rocket]] greets him with "Hail Giovanni!", because [[spoiler: he's not the leader of Team Rocket any more. She blew her cover.]]
* MoralEventHorizon: Candace breaking and entering into the Olivine Town lighthouse, [[spoiler:now a shrine to honor Jasmine who sacrificed herself to allow the rest of the town to survive]], by way of Forretress' Mirror Shot to get the badge, [[spoiler:considered a sacred object by the survivors]], was viewed as this by some people.
* NightmareFuel: '''Everything'''.

!!!Nyachan's Nuzlocke Challenges:
* ShipToShipCombat: So much in her ''Pearl'' run, between Lily/Gary and Lily/Kess, that she had to threaten to holler at the mods in the opening post of her ''Sapphire'' run. [[spoiler:Gary won]], if you're interested, but WordOfGod says the author originally intended [[spoiler: Lily to end up with Kess]] before doing a total 180, which was probably the cause of this.

!!!Petty's Nuzlocke Runs:
* HarsherInHindsight / HilariousInHindsight: Near the ending parts of [=FireRed=], it was shown Petty's rival suffered immense injuries trying to capture Mewtwo, even losing an arm. Fast forward to 2013 and [[spoiler: the same thing happens to Green in ''Anime/PokemonOrigins'', but replace amputated arm with a broken one]].
* JerkassWoobie: Gary Oak, playing strongly on the angry unfavorite interpretation.
* TheWoobie: Silver's Chikorita.

!!!Kynim's Nuzlocke Runs:
* CrossoverShip: Nina is shipped with James, the protagonist of Death's Nuzlocke. (Apparently, they're {{Tsundere}} for each other.) The ship is known as [[http://kynimdraws.tumblr.com/post/42391191834 "Nuzlocke Grumps"]], and has [[http://www.tumblr.com/tagged/nuzlocke-grumps lots of fanart]].
* EnsembleDarkhorse: Kynim wasn't really expecting all the love Mimi got from the instant she joined the team.
** Jasper the Joltik, who helps out N in Chargestone Cave, was a smash hit despite him being a one-point character. Apparently, his design and mannerisms reminded the readers of [[BravestWarriors Catbug]] so much that even the author [[http://ky-nim.deviantart.com/art/Nuzlocke-White-Extra-Comic-22-361793480 acknowledges this.]]
** Leif, Cheren's Serperior, became the first mon that wasn't under the ownership of either protagonist to get their own [[MoeAnthropomorphism gijinka artwork]] due to demand after one of the White Extra comics helping Zach out.
** And speaking of Cheren, he's been getting more love since his characterization in the comic of helping Nina cope with the loss of [[spoiler: Jordan]] in a mature and caring manner is unique and refreshing compared to the [[ContemplateOurNavels tiring and overly-introspective]] route from the games to [[RonTheDeathEater those who tend to twist the rivals into being much more horrible than they actually are]]].
* HilariousInHindsight: Jordan is dressed up with a [[Series/DoctorWho Fez and Bowtie]] [[http://ky-nim.deviantart.com/art/White-Nuzlocke-Extra-Comic-13-274029581 in Extra Comic 13 of Kynim's White Run]]. [[http://kynimdraws.tumblr.com/post/38603021005 The author became a Whovian later.]]
* NightmareFuel: The vision Skyla's fiancee gets when she touches Nina, [[spoiler: displays a Hydreigon wrapped around her. Nina looks absolutely ''[[DespairEventHorizon broken]]'', and the scene is drawn with a creepy ArtShift. What is worse is that anyone who has played Black and White knows who [[ThatOneBoss the dragon belongs to]] and knows [[KillEmAll what it can do]]. It makes it rather horrifying to wonder how it will play out]].
* RonTheDeathEater: Bianca's father gets it worst, turning him into a StrawMisogynist and heavily implied to be a domestic abuser where in the games he was simply worried about Bianca's safety. Clay also gets hit with the StrawMisogynist stick, criticizing Nina's shorts as indecent and just generally being extremely unpleasant.
* {{Shipping}}: VERY prevalent in both comics.
** During her Diamond run [[http://s7.zetaboards.com/Nuzlocke_Forum/topic/8421769/1 Kynim]] dates [[spoiler:Roark]] after [[spoiler:beating him in a [[http://fav.me/d37j1la Gym Battle]]]]
** Her White run is ''full'' of [[ShipTease ships getting teased]]. And [[http://mythsofunova.tumblr.com/post/62295370918/mewitti-replied-to-your-post-they-wouldnt-be the author admits that she shipteases]] in response to crazy fans who may have ShippingGoggles on a bit too tight for her liking.
* ThatOneAttack: Selfdestruct.

!!!Lyrax's Gold Run:
* MoralEventHorizon: Lyrax's Gold run immediately establishes the rival as irredeemable when he [[spoiler: steals ''both'' of the leftover starters, apparently just so he could tell Lyrax "Don't follow me or I'll ''kill'' one of them." He does]].

!!!In Azza's Run:
* MoralEventHorizon: Charmeleon (and his trainer as well) make it clear they're well over the line when Raticate argues that the murder of innocent Pokemon was completely unnecessary, and demands to be released from the team. They do so, but then Charmeleon claims that since Raticate is now a wild Pokemon, he can do whatever he wants, and very brutally murders Raticate as well.

!!!ShiningAce's Nuzlocke:
* NightmareFuel: This comic's version of Giovanni is basically a mass-murderer who's ''proud of it''. He gets several terrifying NightmareFace shots too.
* {{Shipping}}: Notable as [[http://s7.zetaboards.com/Nuzlocke_Forum/topic/8415965/1/ ShiningAce's Nuzlocke]] he is [[spoiler:in an arranged marriage with Erika]]
** [[spoiler:And then he met Sabrina...]]
** Lampshaded in [[http://img5.imageshack.us/img5/3182/curseofextra8.png this]] extra comic.

!!!Manic's Screenshot Runs:
* BaseBreaker: Anemoi has quickly established himself to be this.
* TheScrappy: Beat has quickly established herself as this due to being a bigger Jerkass than Anemoi and for telling [[TheHeart Bump]] to kill himself.
** From his new "Dark Stars" run, Sugar the Smoochum has acquired this status due to her obnoxious behavior and turning Sophie against Manic.

!!!Kit's Nuzlocke Adventure:
* AlternateCharacterInterpretation: Cynthia as a raging AlphaBitch who mocks Kit whenever she can. [[spoiler: To the point where secretly a grown up Angelica from Rugrats!]]
** Silver as just a nice guy everyone hates for no reason. He noticed Elm drop a starter's Pokeball and tried to give it back, Elm accused him of stealing, and he fled.
* EnsembleDarkhorse: Ashes, lampshaded in every later run.
** Felony the Liepard.
* MoralEventHorizon: Kit considers Kyogre killing his Grumpig to be this, even nicknaming the legendary "Murderer"
** Baskerville manipulating Fortune into hugging her in frount of Lyra, after finding out Lyra had a crush on him, was probably the point she earned her Scrappy status below. [[spoiler: She's killed off pretty soon after, only expressing remorse for doing this when she's about to die.]]
* NightmareFuel: The Black run, due to it being the interpretation of the glitchiness that occurred when the author used cheats to sequence break in the game.
* TheScrappy: Baskerville. Initially she seemed like a well-meaning jerk, but later she was proven to be pure jerk. [[spoiler: She did get a bit of an AlasPoorScrappy moment when she died though.]]
* TheWoobie: Silver

!!!Other comics:
* NightmareFuel The Unnamed Protagonist from [[http://s7.zetaboards.com/Nuzlocke_Forum/topic/8579823/1/ Pitch Black]] is a [[NightmareFuel terrifying]], evil, sadistic protagonist. From the beginning it's established that he's NOT a good character, (Considering we see his first activities IMPALING POKEMON ON HIS PICKET FENCE). From then on, any Pokemon he catches he forces to fight and brutally murder his friends and family and sees them nothing more as tools, even going as far as to [[spoiler: KILL his own Pokemon]]. Basically, he's an even worse version of Paul. His Oshawott, Icarus, MAY be just as bad.