- Adaptation Displacement | Older Than They Think: If you think not many people remember this show, try finding someone who knows there were a novel and three movies featuring Clifton Webb as a "Mr. Belvedere" character decades before.
- Critical Research Failure: When Mr. Belvedere's novel fails to sell, George tries to comfort him by pointing out that Dr. Seuss' first book was a flop. Belvedere says Seuss's first book was The Cat in the Hat, while George thought it was Horton Hears a Who!. The fact is they're both wrong, as Dr. Seuss's first book was actually And To Think That I Saw It On Mulberry Street.
- Ear Worm: The show's Thematic Theme Tune, a Dixieland-style number performed by Leon Redbone. Don't click on this if you don't want it stuck in your head the rest of the day.
- "Funny Aneurysm" Moment: The running gag about Mr. Belvedere's predilection for junk food becomes a lot less funny in the wake of Christopher Hewett's death in 2001 from diabetes complications.
- Harsher in Hindsight: In "Commentary" George is fired from his job for criticizing the national anthem being played in every sporting event. This controversial debate became relevant again, after 2016 when Colin Kampernick refused to stand for the anthem in the NFL, claiming that the anthem has a forgotten racist past.
- Hilarious in Hindsight: Kevin using a video camera for a school project in season 2's "The Lion Sleeps Tonight" is this given that Rob Stone would end up becoming a documentarian after Mr. Belvedere ended its run.
- Retroactive Recognition:
- Christopher Hewett (Mr. Belvedere) is also best known for playing Roger DeBris in The Producers.
- Bob Uecker (George) is also best known for playing Harry Doyle in Major League.
- Jack Dodson had a recurring role as Carl Butlam, one of the spokesmen for the Happy Guys of Pittsburgh. Dodson is best known for playing Howard Sprague on The Andy Griffith Show and its After Show, Mayberry R.F.D..
- Willie Garson also had a recurring role as Kevin's best friend, Carl. Garson is best known for playing Mozzie on White Collar.
- In addition to Mr. Belvedere, theme song writers Judy Hart-Angelo and Gary Portnoy also wrote the theme songs for Cheers and Punky Brewster, for which Portnoy also sang.
- Suspiciously Similar Song: The tune playing during the montage of Kevin performing his nurse duties in one episode sounds a lot like the St. Elsewhere theme.
- Tear Jerker: The final scene with Mr. Belvedere and the Owens family in season 6x22, episode #117, part 2 of the series finale, "Mr. Belvedere's Wedding". After he takes one last look at his bedroom, he then says his goodbyes to each member of the family from oldest to youngest. Of course, he saves the best for last with Wesley, whom, despite the often humiliating moments, loved him very much. It's both funny and sad at the same time.
Wesley: "I know I'm losing my best friend."Mr. Belvedere: "Wesley, I've known heads of state, and many celebrities. But none have given me finer memories than you. I shall savor our moments together. Even the embarrassing and painful ones. Which account for most of them. Though you are an Owens, I shall always think of you as a son."
Wesley: "He's gone."
- The two of them then hug each other. His new wife, Louise, then reminds him it's time to go with her to Africa. After bidding one final farewell, he leaves, and the scenes ends with the family peeping out the front door for one final look, as Wesley says his final line on the show: