These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Crowning Moment Of Awesome: 19th century Edo as a whole during the cholera. Without panic or resignation they organize a quarantine, care for the sick, instantly understand Jin's explanations of what causes it and how to treat it without much superstitious awe or clinging to past ideas and then proceed to manufacture the needed medical tools en masse with only manual skills. They beat back an epidemic that scourged them many times with sheer comprehension and discipline and show themselves as anything butMedieval Morons.
Squick: Open-brain surgery—with carpenter tools. And a bursting cerebral edema. Also, it's hard to preserve much dignity when suffering from cholera and a cholera epidemic is no fun for anyone.
There's also the geisha girls dying of syphillis and other venereal diseases. The withered, skeletal looks on their faces simultaneously bring out Nightmare Fuel and Tear Jerker.