* AlternateCharacterInterpretation: Is Caine really that evil and crazy, or did his fellow scientists force his hand? Did the serum make him less empathetic and psychotic or did invisibility simply allow him to indulge in his darker desires?
** It may be both. At the beginning of the movie, the guinea pig turned invisible devoured the still visible one. Which means that the serum may indeed affect the user's psyche... Not that Caine's wasn't fractured to begin with.
* CriticalResearchFailure: When Caine is injected with the serum there is visible air bubbles in the fluid. Getting air bubbles injected is at best very painful, at worst fatal.
* MoralEventHorizon: [[RapeIsASpecialKindOfEvil The invisible rape sequence.]]
* ParanoiaFuel: One of your colleagues is invisible. And insane. And right behind you. ''And he wants to kill you.'' (Rape is not off the table either.) Trying to electrocute him (the cure) will just turn him into a mass of [[BodyHorror walking organs]].
** There's also the part of the film where Caine drags a guy into a pool and drowns him, and the guy's wife looks outside and thinks her husband just fell in.
** The transformation sequence. It's possible that even a single drop of serum is enough. Your heart just felt warm and is tingling?
* RetroactiveRecognition: Greg Grunberg (the pilot in ''{{Series/Lost}}'', Matt Parkman in ''Series/{{Heroes}}'') plays a supporting character.
** Another scientist is Kim Dickens (Cassidy in ''Lost'', Ms. Stubbs in ''{{Series/Deadwood}}'').
** Creator/RhonaMitra, the vampire in ''[[{{Underworld}} Rise of the Lycans]]'' and "The Gates" is the rape-victim. Her vamp powers would have come in handy here.
* VisualEffectsOfAwesome: Both the transition from/to invisibility and the invisible effects themselves are impressive. The 3D model of Kevin Bacon has since been donated for scientific research.
* TheWoobie: The raped neighbor. She's been raped by an invisible man. Exactly how would she cope with what happened? Especially since [[FridgeHorror there's no way she can tell anyone the invisible man without being seen as crazy]].
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