!!In the comic miniseries:
* NauseaFuel: Some sections are hard to get through, due to the intense combination of Eddie Campbell's artwork and Moore's disturbing subject matter. An entire chapter is devoted to a graphically detailed dissection of a corpse.
** Creator/NeilGaiman once [[https://youtu.be/337-ycZz6IM related an anecdote at a con]] in which Moore described such a scene to him. While he was eating. ''[[{{Squick}} Halfway through the meal]]''. Gaiman had to step outside not once but ''twice'' during the conversation to get some air, which led to Moore nicknaming him [[CrowningMomentOfFunny Neil "Scary Trousers" Gaiman, Master of Modern Horror]].
* TheWoobie:
** The chapter isn't called ''The Unfortunate Mr Druitt'' for nothing.
** All of the prostitutes and victims are this. They are forced into their line of work because of abject poverty and are subject to rape, violence and can't turn to the church or the police for help because they are looked down upon as less than human; and then they start being killed off because of something that had nothing to do with them. It says something that it took Jack the Ripper's killings to bring attention to their appalling living conditions and exploitation.

!!In the movie:
* AlternateCharacterInterpretation: In the end, is [[spoiler: Abberline's death from opium overdose just an accident, or does he kill himself because he can't ever see Mary again?]]
* {{Narm}} : The chief morgue attendant's general overreaction to the state of the prostitutes mangled bodies, especially when Abberline points out that the killer is stealing their organs. Looking at dead bodies in various degrees of mutilation has been his ''job'' for at least a few decades; surely he'd be used to this sort of stuff by now?!?