''The Ruff & Reddy Show'' was the first production of the Creator/HannaBarbera studio and the very first network cartoon made specifically for Saturday morning. It premiered December 14, 1957, on Creator/{{NBC}}.

Ruff was a kitten and Reddy a dog, and together they got involved in clandestine escapades involving anything from alien invasions to swamp pirates to treasure plunderers. In some adventures, they are assisted by Professor Gismo, a kindly old scientist. Taking a cue from ''WesternAnimation/CrusaderRabbit'', it was serialized with 13 episodes making up a story arc and four story arcs making up a season. They were seen as features of the network show which had live action segments. The first run (195760) was hosted by Jimmy Blaine, the second run (196264) had Captain Bob Cottle in the host segments. The first run also featured cartoons from Columbia's theatrical short subjects.

''Ruff & Reddy'', which was all but rejected by Creator/ColumbiaPictures president Harry Cohn (he was overruled by Columbia's financial officer, John Mitchell--the studio bankrolled and distributed the series), was sponsored by General Foods (maker of Post cereals) and was a modest success. Hanna-Barbera would achieve runaway success a year later with ''WesternAnimation/TheHuckleberryHoundShow''.

!!This Hanna-Barbera cartoon provides examples of:

* AccessoryWearingCartoonAnimal: Both Ruff and Reddy; Ruff wears a bow tie and Reddy has a dog collar.
* AssuranceBackfire: From the narrator in the "Westward Ho Ho Ho" story arc:
-->'''Narrator:''' Good old Reddy. He never makes the same mistake twice. He just keeps making new ones!
* AxCrazy: Salt Water Daffy, who always has a tommy gun in hand.
* ButtMonkey: Reddy. Noble but not too bright.
* TheCameo: Ruff and Reddy appeared briefly in 1972's ''WesternAnimation/YogisArkLark'' (the pilot to ''WesternAnimation/YogisGang''), and Ruff cameoed in a 1986 episode of ''WesternAnimation/YogisTreasureHunt''.
* CaptainObvious: Like many serialized cartoons of the time, ''Ruff And Reddy'' had a narrator with a penchant for describing virtually everything going on in the episode.
* CatDogDichotomy: See CuteKitten and DogsAreDumb.
* CatchPhrase: Captain Greedy's "I'll boil them in oil!" and "I hate them to pieces!"
* ComicBookAdaptation:
** Ruff and Reddy appeared in 12 issues from Dell Comics, starting with Dell Four Color Comics #937 (adaptation of the Pint-Sized Pachyderm story arc). Most issues were drawn by Harvey Eisenberg, others were drawn by Pete Alvarado.
** Professor Gismo is a central figure in the Marvel Comics special ''WesternAnimation/LaffALympics'' publication "The Man Who Stole Thursdays" (summer, 1978). Ruff and Reddy are seen in a framed picture on Gismo's wall in a panel.
** Much more recently, as part of Creator/DCComics' ''ComicBook/HannaBarberaBeyond'' initiative, Ruff and Reddy are now depicted as a pair of struggling stand-up comedians in the 1950s; their first appearance is as the backup to ''ComicBook/GreenLantern'' / ''WesternAnimation/SpaceGhost''.
* CrouchingMoronHiddenBadass: Reddy. He may be dense and a little chicken at times, but when it comes to Ruff and anyone weaker than its antagonizer, he'll step up to the plate.
* CuteKitten: Ruff
* DastardlyWhiplash: Scary Harry Safari
* DogsAreDumb: Reddy isn't the sharpest tool in the shed.
* FoodPills: In the Lillipuni Planet story arc, Ruff and Reddy are tricked by a professor into being launched into space on a fact finding mission to the moon. Inside the rocket, Reddy asks for a six-course lunch:
-->'''Professor:''' You'll find everything you need on board. Hamburger pills...\\
'''Reddy:''' Hamburger pills??!\\
'''Professor:''' Hot dog pills, lemonade pills, and milkshake capsules.\\
'''Reddy:''' What if I get a headache?\\
'''Professor:''' Then you take an aspirin sandwich.
* MythologyGag: The name WesternAnimation/QuickDrawMcGraw appears on a note nailed to a sheriff's door in an episode involving a ghost town and missing sheep. Also, the cave boy Ubble-Ubble (Chickosaurus story arc) was said to be the inspiration for Bamm-Bamm on ''WesternAnimation/TheFlintstones''.
* OneWheeledWonder: The [[SdrawkcabName Muni Mula]] men balance on a single wheel.
* RhymesOnADime: Many "next episode" titles fall into this.
* SdrawkcabName: The first story arc, "Planet Pirates," had our heroes taken to a planet Professor Gismo called Muni-mula, which is backwards for "aluminum," the substance of which the planet is made.
* ShorterMeansSmarter: Ruff is clearly the brains of the outfit. Also, Prof. Gismo is almost as short as Ruff.
* TheSmartGuy: Ruff. And Professor Gismo sometimes.
* ThoseTwoBadGuys:
** Killer and Diller, "the Terrible Twins from Texas". They'd be reused and renamed in the WesternAnimation/YogiBear cartoon "Big Brave Bear".
** Also, Captain Greedy and his stooge, Salt Water Daffy.
* WhatHappenedToTheMouse: At the end of the Chickosaurus story arc, Professor Gismo adopts cave boy Ubble-Ubble. In the Prof's ensuing appearances on the show, we never see or hear of Ubble-Ubble again.
* YouWouldntLikeMeWhenImAngry: Reddy in spades. As mentioned, he'll shy away from confrontations, but pick on Ruff or anyone smaller than its antagonist and he'll get riled.