* AsHimself: A doctor and a bodyguard who took care of Flynt in real life do the same on-screen here.
* CreatorCameo: Flynt himself plays a judge. The screenwriters also have brief appearances.
* DawsonCasting: Music/CourtneyLove was 32 when she played Althea. The real Althea was sixteen (the age of consent in Ohio) when she started at Larry's strip club.
* IronyAsSheIsCast: James Carville, a well-known [[UsefulNotes/AmericanPoliticalSystem liberal Democrat]] in RealLife, plays Simon Leis, the Ohio prosecutor who first charged Larry with obscenity.
* RealLifeRelative: Brett Harrelson, Woody's brother, played Larry Flynt's brother Jimmy.
** Larry's satiric Presidential campaign in 1984 was left out of the movie, since the writers believed that focusing on Larry's feud with Jerry Falwell, culminating in his victory at the Supreme Court, was a better way to make the film's points.
** Both Tom Hanks and Bill Murray were considered for the role of Larry Flynt.