- Actor-Shared Background:
- Megalyn Echikunwoke, like Isabelle, was born to a Black father and White mother.
- Karina Lombard's birthplace is Tahiti, as was Alana's.
- California Doubling: The series was filmed in Vancouver, Canada but set in Seattle.
- Dawson Casting: When the series began in 2004, Patrick Flueger (Shawn), Brooke Nevin (Nikki) and Kaj-Erik Eriksen (Danny) were 20, 21 and 25 playing 17-year-olds.
- Directed by Cast Member: Helen Shaver directed "The New and Improved Carl Morrissey" and played Barbara Yates in the two succeeding episodes "Becoming" and "Trial by Fire".
- Fake American: The Canadian Chad Faust, plus Australians Jenni Baird and Jacqueline McKenzie play American characters.
- The Other Darrin: Barbara Yates was played by Patti Allan in "Pilot" and Helen Shaver in "Becoming" and "Trial by Fire".
- Real-Life Relative: In "Weight of the World", the real life married couple Colin Lawrence and Lucia Walters played David and Tara Kendrick.
- You Look Familiar: Leanne Adachi played a nurse in "White Light" and the recurring character T.J. Kim in Seasons Two and Three.
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