* ActorExistenceFailure: Very narrowly averted--the show ended literally just over a month before Eartha Kitt passed away.
* MissingEpisode: For no apparent reason, episodes 43 ("Father O'Mine" and "Everybody Loves Kuzco") and 49 ("Faking the Grade" and "Eco Kuzco") are never shown in the DisneyChannel's rerun rotation. The Kuzcoween, Cornivale, and Giftmas episodes also fall under this, but it's because they're holiday episodes.
* TheOtherDarrin:
** J.P. Mannix replaces David Spade for the role of Kuzco.
** Fred Tatasciore replaces John Goodman as Pacha. This was only for the first season, as Goodman was able to reprise his role in the second season.
** In the Japanese dub, Creator/ShowtaroMorikubo replaces Tatsuya Fujiwara as Kuzco [[CelebrityVoiceActor for obvious reasons]].
* RealLifeRelative: At the time in the Japanese dub, Creator/ShowtaroMorikubo and Creator/YuuAsakawa (Kuzco and Malina's respective voice actors), were married--however, they're now divorced.