* TheCastShowoff: Gabrielle's final scene in her first run has her speaking fluent French. Actress Virginie Le Brun is the daughter of NZ-based French vintner Daniel le Brun.
** In 2010, a play starring several characters is directed by receptionist Yvonne Jeffries. Actress Alison Quigan is a theater writer and director with over 20 years experience, including holding a Queen's Service Medal for her services to theater.
* LifeImitatesArt: There have been a lot of coincidences between Shortland Street storylines and real life, that it has become known as the "Shortland Street Curse".
** In 2003, Shortland Street Hospital had its back-up generator fail during a power outage - less than two weeks later, the same thing happened at Auckland's Starship Children's Hospital.
** The feature length 20th anniversary show featured a helicopter crash, and by coincidence, the day the episode aired, there was a fatal helicopter crash in Canterbury. The show went to air with a last-minute ContentWarning since they couldn't pull the episode without breaking continuity.
* TheOtherDarrin: Justine Jones was recast with Lucy Wigmore in the role, who replaced Laurie Foell who had played Justine for the character's first two years on the soap.
** Chris Warner's son Harry Warner has been played by four different actors since his birth: Joshua Thompson (2002), Callum Campbell Ross (2002-2006), Henry Williams (2006-2009), and Reid Walker (2009 onwards)
*** Daniel Potts was played for his first 3 years by Jarred Blakiston. When the character returned as a full member of the cast in 2009, he was turned into a "heartthrob" and so was recast with Ido Drent in the role instead.
* UnderAgeCasting: Some doctors and nurses are played by actors who are too young to hold such a job in real life. The minimum age in New Zealand (ignoring any child prodigies) is 20-21 for a nurse, and 23-24 for a junior doctor.
** Surgeon Victoria Anderton first appeared in early 2015, played by 22-year-old Laura Thompson.
** Nurse Lucy Rickman first appeared in mid-2014, played by 19-year-old Grace Palmer.