* ActorAllusion: [[Film/X2XMenUnited Colonel Stryker]] is seen in the trailer saying, "[[WhatMeasureIsANonHuman They're not people, you know.]]"
** [[Creator/TomFelton Draco]] [[Film/HarryPotter Malfoy]] doesn't seem too friendly towards the non-humans either.
*** [[Creator/TomFelton Draco]] [[Film/HarryPotter Malfoy]] holding the electrocution wand, anyone?
*** [[Creator/TomFelton Draco]] [[Film/HarryPotter Malfoy]] saying "You think that's ''funny?''" and "You're ''next!''"
** [[Film/TheLordOfTheRings Biting off someone's finger]] again, are we, [[Creator/AndySerkis Gollum?]]
*** Andy Serkis as [[Film/KingKong2005 another Ape]], no less, (if smaller and smarter).
** John Lithgow becomes friends with a primate. [[Film/HarryAndTheHendersons Again.]]
* ActorSharedBackground: Douglas Hunsiker being a family man who goes PapaWolf to protect his kids from Ceasar alludes to MeanCharacterNiceActor David Hewlett who plays him being a family man in real life, albeit much nicer then Hunsiker, as he has a son whom he adores - to the point where he merrily Twitters about his latest antics at least once a day.
* CaliforniaDoubling: Inverted -- New Zealand for UsefulNotes/SanFrancisco.
** Surrey-born David Hewlett plays the Californian Douglas Hunsiker.
** Likewise, John and Dodge Landon are played by Angus-born Brian Cox and Surrey-born Creator/TomFelton with Californian accents.
* ShownTheirWork: ''Possibly''. A leading theory for the cause of the rapid spread of AIDS in North America is "a promiscuous flight attendant". With even more air travel and an easier route of transmission, the spread isn't that hard to believe.
** Rocket makes noise with a gas can to reinforce his position as leader. Later, Caesar uses the same gas can to hit Rocket, and ends becoming the new leader of the sanctuary. This is reminiscent of a real case studied by Jane Goodall, where a clever young chimp realized that the noise made with a gas can scared the other chimps and used it to become the tribe's leader.
* ViralMarketing: [[http://www.simianflu.com/ Simian Flu]], an in-universe website to promote the sequel.
** Tobey Maguire was originally intended for the lead human role, but when it fell through, they settled for James Franco instead. [[Film/SpiderManTrilogy It's not the first time Harry Osborn has been second best to Peter Parker.]]
** They also had earlier drafts with a sympathetic vet character (named Stewart, after the unlucky female astronaut in the first film) working at the lab who becomes involved with Will, but this was later replaced by the zoo vet character. Before the character of Will's father with Alzheimer's, there was a draft with the lead humans being a geneticist and his wife with the disease.
** The most ironic part is that the first script wasn't even written as part of the ''Franchise/PlanetOfTheApes'' franchise but was based on reports of real people raising chimps as pets (or ''babies'') and then getting mauled in their homes when they become [[TeensAreMonsters teenagers]]. The first incarnation of what would become Caesar was '''evil''' and talked [[spoiler:only]] in sign language; its genre was probably closer to a sci-fi horror than the drama/adventure movie it ended being.
** Will died in the first cut of the film, but test audiences didn't like it. Though he died between films anyway.