- The Other Darrin: Fiona Gillies was the producers' first choice to play Clare Shearer, when the character was introduced in 1997. However, she was expecting a baby at the time, and so was unable to accept the role, which instead went to Yolanda Vazquez. When Vasquez decided to leave at the end of season five, the producers debated whether to kill off her character, but instead they approached Gillies again. This time she was free to take over the role.
- What Could Have Been: Zoƫ Wanamaker was offered the role of Dr. Beth Glover.
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