* CareerResurrection: Alyssa Milano.
* DawsonCasting: Averted as the characters' ages aren't actually mentioned. However, many of the actors were younger than the actors who portrayed the ''teen'' characters on the show's progenitor series ''Series/BeverlyHills90210'' (e.g. Gabrielle Carteris, Andrea from ''90210'', was eight months older than Heather Locklear).
** Also, Laura Leighton (Sydney) was older than Josie Bissett (Jane), though in-series, it was inverted.
* ExecutiveMeddling / WhatCouldHaveBeen: Hunter Tylo of ''Series/TheBoldAndTheBeautiful'' was to play the original [[BitchInSheepsClothing Taylor McBride.]] However, she was fired due to becoming pregnant, which she had successfully sued the show's creator, Aaron Spelling and the show's producers for her dismissal.
** Doug Savant and Marcia Cross later became co-stars on ''Series/DesperateHousewives''.
** Laura Leighton later went on to portray Hanna's mom on ''Series/PrettyLittleLiars''.
** Courtney Thorne-Smith landed roles on ''Series/AllyMcBeal'' (which was the reason why she left ''Melrose Place''), ''Series/AccordingToJim'', and ''Series/TwoAndAHalfMen''.
** Kristin Davis, better known as Charlotte from ''Series/SexAndTheCity''.
** Daphne Zuniga later became Brooke Davis' mom on ''Series/OneTreeHill''.
** Vanessa A. Williams, as Maxine from ''Series/SoulFood''.
** Kelly Rutherford, a.k.a. Serena's mom Lily from ''Series/GossipGirl''.
** Linden Ashby later became the father of Stiles on ''Series/TeenWolf''.
* RomanceOnTheSet: Several occasions, such as real-life married couple Josie Bissett (Jane) and Rob Estes (Kyle)[[note]]who, sadly, have since divorced[[/note]] ending up together in the finale, Grant Show (Jake) and Laura Leighton (Sydney) dating and she and Doug Savant (Matt) eventually marrying.
* UnintentionalPeriodPiece: Well, it was set in the 1990s, with then-contemporary references sewn in for good measure.