* [[BannedInChina Banned In Singapore]]: For about two days.
* CanadaEh: Believe it or not, both Shepards Voice Actors are Canadian. While Jennifer Hale is fairly good at hiding the accent, Mark Meer tends to fall into saying "Aboot" every once and awhile.
* CashCowFranchise: Not quite yet, but due to the universe's detail, depth, and extreme popularity, many are expecting BioWare to take it in this direction.
** Four novellas, two comics (plus two free mini-comics), and three spinoff [[IOSGames iPhone]] games, so far.
* CelebrityVoiceActor: ''All'' over the place. Creator/SethGreen, Creator/AdamBaldwin, Creator/YvonneStrahovski, Creator/TriciaHelfer, Creator/MartinSheen, Creator/ClaudiaBlack, [[Film/TheMatrix Carrie-Anne Moss]]... the list goes on. In fact, it could be said that the in-development movie could very well be made with many of the characters literally being played by their voices (in fact, FanDumb might result if anything else were to happen in some cases!)
* HeyItsThatVoice: The narrator for the Codex data files is [[VideoGame/MetalGearSolid3 Colonel Volgin]].
** [[KeithDavid Goliath]]/[[Franchise/{{Halo}} The Arbiter]] is Captain Anderson.
** Creator/LanceHenriksen is Admiral Hackett.
** [[Creator/SethGreen Oz]]/[[WesternAnimation/FamilyGuy Chris Griffin]] is Joker.
** [[Series/StarTrekTheNextGeneration Counselor Troi]] is Matriach Benezia.
** [[Creator/DwightSchultz Barclay]] is Navigator Pressly.
** [[Series/StarTrekDeepSpaceNine Quark]] is the Salarian councilor (Valern) and Fai Dan.
** [[RegularShow Rigby]] is Mordin Solus, at least in the third game!
** [[Series/BattlestarGalactica2003 Colonel Tigh]]/[[VideoGame/TheElderScrollsVSkyrim General Tullius]] is Commander Bailey.
** Major Coats is [[VideoGame/DragonAgeII Hawke.]]
** [[Creator/AdamBaldwin Jayne Cobb]] is the Quarian marine Kal'Reegar.
** The Illusive Man is [[Creator/MartinSheen President Bartlett and Captain Willard]].
* InspiredBy: Mass Effect's technological aesthetics, particularly of the omni-tools and Alliance armor, were heavily influenced by box office bomb Anime/FinalFantasyTheSpiritsWithin. The game's art director was a big fan of the movie's style.
* InternetCounterattack: If you're an author who is claiming the game is a sex simulator, don't shriek you've never played the game. Just...don't. Cooper Lawrence learned this lesson soon after her claims when her book was bombarded with poor reviews beginning with, "I've never read the book, but..." (Hilariously, the reviews that ''didn't'' begin with that phrase were rarely much better!)
* RelationshipVoiceActor: Almost example, as Mark Meer ([=MaleShep=]) is married to Belinda Cornish, who voices Rana Thanoptis, the asari scientist who shows up on Virmire and has a minor role in the next two games.
* TheWikiRule: [[http://masseffect.wikia.com/wiki/Mass_Effect_Wiki The Mass Effect Wiki]].
* WhatCouldHaveBeen: At one point, it was going to be possible to [[spoiler:save both Kaiden & Ashley. This was removed when the developers realized no one would want to go on to further games with one of them dead if given the option]].
** When Creator/DrewKarpyshyn was still attached as head writer, the Reapers' motivation was originally linked to the buildup of dark matter in the galaxy from overuse of eezo; hence the strange readings from Haestrom's sun in ''Mass Effect 2''(see AbortedArc). Their rationale was going to be that the energy can't accrue if there's nobody in the galaxy advanced enough to make it. When Karpyshyn was re-assigned to ''StarWarsTheOldRepublic'' after ''Mass Effect 2'', the new writers instead went with [[spoiler: the general conflict between organics and synthetics]] we see in ''Mass Effect 3''.