Trivia / Destroy All Humans! 2: Reprobed

• Cut Song: A few of the original game's copyrighted songs ("Pattern Skies" by The Greenhornes, "Turn It Off" by The Guilty Hearts, "Help You Ann" by Lyres, and "Long Road" by Mark Watrous) were removed here. Missions that play any of these songs simply mute the sounds or use the normal soundtrack instead.
• Real Song Theme Tune: Like in the previous game, promotional material features a montage of events that happen in the game to the tune of the Rammstein song "Amerika", even spoofing the moon-scenes from the original music video.