* ComicBook/LexLuthor was originally drawn with [[EvilRedhead red hair]], but was abruptly changed to [[BaldOfEvil bald]] after an artistic mistake by illustrator Leo Nowak. Not only has it stuck with Luthor's popular image ever since, but was indirectly responsible for Luthor taking the Ultra-Humanite's place as Supes' arch nemesis as DC didn't want two bald mad scientists battling Superman (and thus Ultra-Humanite gained his trademark tendency to BodySurf and was PutOnABus for several decades).
* During one arc of ''ComicBook/{{Invincible}}'', [[spoiler: Omni-Man]] marries an insect-like alien, and there's a panel of him kissing her and Invincible looking disgusted. According to the sketchbook in the back, the artist made this as a joke and Robert Kirkman decided to keep it in the actual issue.
* ComicBook/{{Wolverine}}'s iconic mask was due to this trope - when he joined the ComicBook/XMen in ''Giant-Size X-Men'' #1, he was meant to keep the same mask design that he had when he first appeared in ''ComicBook/IncredibleHulk'' #181. However, the person who drew it, made the ears and eyes too wide. However, when it was shown, they thought that it made him look like Franchise/{{Batman}} and was kept in.
* In the script for an issue of ''ComicBook/{{Aquaman}}: The Atlantis Chronicles'', Peter David described the "face" of the meteor that destroyed Atlantis. He meant it metaphorically, but the artist, working from a script translated into Spanish, took him literally and drew the meteor with a skull face on it. When he saw the art, David said "Keep it," reasoning that the only thing more terrifying than a meteor heading right for you is a meteor heading right for you WITH A SKULL ON IT.
* Done in-universe in two Italian ComicBook/DisneyMouseAndDuckComics stories:
** In ''Il Papero del Mistero'' ("The Duck of Mystery") Scrooge sets himself and his relatives to make a soap opera, and specifically tells everyone that he won't give them any script, only character names, initial roles and a scenario and then they'll have to improvise. Cue such gems as an episode where everyone but Scrooge's character get poisoned by the others (in two occasions by ''accident'', because Gus' character stole a slice from a previously poisoned cake and the nephews' characters made Grandma Duck's character taste their attempt at the formula of a Coca Cola {{Expy}} and Grandma Duck decided they failed), Donald faking an AlienInvasion episode when the other actors go on strike, and ''Jubal Pomp photobombing his way in the story with attempts on Scrooge's life'' ([[WhatDoYouMeanItWasntMadeOnDrugs it's that kind of story]]).
** In ''Topokolossal'' Mickey and friends are tricked by Pete, Black Spot and Portis (who had made a good theft but feared Mickey would expose them) into starring in a sci-fi telefilm whose director is a sadist named [[NamesToRunAwayFromReallyFast Annabel Lecter]], and decided to imitate ''Il Papero del Mistero''. It ''starts'' with Mickey's character [[ItMakesSenseInContext using a baguette as a sword to fight a giant inflatable rat in the castle of the Sleeping Beauty (Eega had been hired as a runner and procured those things as a test]]. She wanted to ''eat'' the baguette, but O'Hara got to it first), and gets progressively crazier.