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Tearjerker: Oz: The Great and Powerful
After seeing his magic act, a Wheelchair Woobie asks Oz if he can make her walk again. It is made a little less saddening later on (see the next entry), but it's still pretty hard-hitting when it happens.
China Girl's introduction, in which her village is destroyed by Evanora and her legs are broken off. Her bitter weeping when she is revealed with her broken legs and tells what happened to her family is especially distressing; even Oz can only look at her silently before he finally thinks of a solution. What makes it even more moving is that it's a Call Back to the prologue in Kansas, where we see Oscar failing to help a girl in a wheelchair who asked him to help her walk again. That girl was played by Joey King, the same actress who voiced the China Girl - and Oscar couldn't afford to let her down again.