Please don't list this on a work's page as a trope. Examples can go on the work's YMMV tab.
Tear Jerker: The Stand
Frannie sewing up a body bag for her dead father and burying him in his garden. All while singing "Amazing Grace".
The film ending,for me.
Every time when Tom is travelling back to Boulder and looks forward to "seeing Nick again." Oh, the irony.
Larry having a Heroic BSOD when he and the rest of the True Companions have to leave Stu behind en route to Las Vegas, dooming him to likely death from exposure and a broken leg. Stu has to talk him back to his senses, and Larry becomes the new leader of the mission.
Not to mention the death of Larry's mother. She dies in the hallway of an overcrowded hospital with Larry kneeling beside her, and nobody else cares or even notices.
For anyone who was the awkward fat outcast kid in school and had trouble leaving all that behind afterwards, Harold Lauder's storyline and eventual fate will hit hard.