* At the very beginning of the first game where [[spoiler:after fighting a posessed Giro, he sacrifices himself to allow Model Z to lend you its power in order to survive.]] And in the implied backstory, [[spoiler:Ciel is murdered by Serpent (who was supposedly her ally) during an expedition to find the biometals.]]
* Towards the end game of ''Advent'', [[spoiler: Prometheus and Pandora get their revenge on Albert - only to have their energy drained by the ''real'' Albert and Model W.]] Even after everything they'd done, [[spoiler: the pair were still entirely forced against their wills to do Albert's bidding, their bodies forcibly mutated by Model W permanently, and then they were left to die at the bottom of the ocean in an exploding base.]] Probably one of the most depressing fates in the franchise for such memorable characters.