- Isabel stays with Alfonso as he's dying. He wakes up just before he dies, and their final conversation is heartbreaking.Alfonso: Do you think I was a good king?Isabel: The best of kings.
- The death of Prince John and the way his parents mourn him.Isabel: God gave him to me, and God took him from me.
- Margaret miscarries afterwards.
- Princess Isabel dying in childbirth.
- Isabel's son Miguel dying as well, causing Queen Isabel to question her faith after all the tragedies that have befallen her.
- Watching Joanna unleash all the shit on her parents and Beatriz in 3x011. Ferdinand raises a hand to his daughter and Isabella is in tears.
