- When Professor Oak makes you release Pikachu back into the wild. Seriously, try not to cry when the music becomes slow and dreary, and you're forced to look into those big shiny eyes and say "goodbye". Don't worry, he comes back.
- The opening theme can move one to tears.
Tear Jerker / Hey You, Pikachu!
Even a game as cute as this can tug at the heartstrings sometimes...