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Season 1
Episode 1 - Birthday Girl
- After the hacker outs Isabela as transgender, most of her friends shamelessly shun her and her boyfriend Pablo, the only person who ever supported her and learned this beforehand (aside from her best friends Natalia and María), betrays her by feigning ignorance in front of them.
Episode 3 - Idiots
- Poor Luis being unable to fight back against Gerry while the other students can only watch as he mercilessly gets beaten up and put into a coma by his bully.
Episode 4 - Night School
- Sofía trying to cut herself with a pair of scissors after deducing that her father not showing up at their usual meeting spot was the hacker's doing. Justified as he faked his own death and would be arrested if that piece of information ever came out.
- Isabela backs out at the last minute when she is about to attend Raúl's party and stays in her bedroom as the female students keep on mocking her via messages for being transgender.
Episode 8 - Public Enemy
- Luis flatlining at the hospital, with his mother crying in agony and a guilt-ridden Gerry silently apologizing to her as he walks out of the room, while at the same time Pablo attempts to rape Isabela. The music playing on the background only makes the scene harder to watch.
Season 2
Episode 7 - Control Z
- Gerry visiting Luis' tomb while sadly reminiscing his former friendship with him. With encouragement from Alex, Luis gave Gerry a drawing he made of him, only to give it back later on and start bullying after Gerry's father made a homophobic comment about it.
Episode 8 - The Ultimate Revenge
- Javier breaking up with Natalia after mistakenly believing that she was boinking his father, to the point of making it clear that he doesn't want to see her again. Natalia is truly saddened that she lost him for good, but more because of the fact that she couldn't get the money she owes to the drug dealers threatening to kill her, let alone on the very last day she was supposed to meet their demands.
Season 3
Episode 3 - You Have Reached Your Destination
- María's suicide. The poor girl went through a lot: getting herself involved with her former best friend's toxic ex-boyfriend, who later started controlling every second of her life, dealing with the stresses of Natalia's bigger debts with the drug dealers, and to make it worse, she was partially responsible for Susana's death, as she had accidentally pushed her off the roof, eventually causing both of them to leave the city. To lessen her suffering, María apparently drowns herself, not before giving a tearful farewell to Natalia.
- María's death is even sadder if you rewatch the season 1 finale and take into account Isabela's departure from the show. The last time they ever saw each other, Isabela ended their friendship after finding out that she was sleeping with Pablo behind her back. To see her die like that sometime following this incident is truly heartbreaking. Isabela never got the chance to know what happened to her. Not a single visit, not a mourning, not even a reconciliation, or a simple "I forgive you". A flashback showing this when the bad news become too much for Pablo to handle don't help matters. It is likely that Isabela will never also know the entire hell she went through in season 2.
Episode 5 - Helena
- Sofía finding out through _@allyoursecrets_ that the young woman she met a few days ago at the hearing is actually a daughter of her father, which makes her realize he has another family. Upon learning this, Sofía is understandably heartbroken that the very person she looked up to has been lying to her the whole time. It's made worse when her half-sister shows absolutely No Sympathy to Sofía.
Episode 6 - Game Master
- Gerry after his homophobic inmates find out he's gay. Not only does poor Gerry get violently beaten up by them, but Bernardo is also coerced into doing so. What makes it even sadder is Gerry imagining Bernardo as Luis beating him up.
