[[caption-width-right:350:Clockwise from right: Adam, Marjorie, Dave, Deena, Nicole, Angelo... and Brian.]]
What About Brian is an {{Creator/ABC}} {{Dramedy}}, produced by Creator/JJAbrams, about three couples at different stages in their relationships... [[MyFriendsAndZoidberg and Brian]].

The show lasted for two seasons from April 2006 - March 2007, and is on DVD in its entirety. Including a MissingEpisode from the already shortened first season.

!!This show provides examples of:
* AccidentalMarriage: Adam married Heather in Las Vegas.
* BonusEpisode: The final episode of the first season is only available on DVD.
* BritishBrevity: A rare American example, as the first season only had '''five''' episodes air on television.
* BusCrash: [[spoiler:Angelo dies off-screen, with the reveal at Nicole's baby shower.]]
* HighSchoolSweethearts: Dave and Deena.
* HowWeGotHere: Done with the {{Pilot}}.
* IdiosyncraticEpisodeNaming: Every episode of the second season begins with "What About" and ends with ellipsis.
* LawOfInverseFertility: Nicole and Angelo struggle with having a baby due to Nicole's age. They finally do conceive [[spoiler:before Angelo dies]].
* LikesOlderWomen: Angelo.
* LoveTriangle: Brian/Marjorie/Adam.
* MayDecemberRomance: Nicole and Angelo.
* MidseasonReplacement
* MinorFlawMajorBreakup: It's said that all of Brian's relationships end because of this.
* MyFriendsAndZoidberg: The concept of the show is a group of people in relationships... and Brian.
* {{Polyamory}}: Deena wants an open relationship, which Dave reluctantly goes along with, with a "don't ask, don't tell" policy.
* PsychoExGirlfriend: Karen becomes this when Brian breaks up with her in the {{Pilot}}. Hilariously referring to Brian is "Ted Bundy", kicking him out of his own house, and leaving him with her dog.
* RunawayBride: Marjorie leaves Adam at the altar.
* [[spoiler:SomeoneToRememberHimBy: Nicole and Angelo's baby, Bella.]]