American Dad!: In "Roy Rogers McFreely", Roger calls out Stan for not letting him do anything that he wants to do, including adopting a rabbit, watching The Hills, and getting a Gael GarcĂa Bernal poster.
Family Guy: The episode "We Love You, Conrad" involves Brian hooking up with Lauren Conrad, and one scene has him and Stewie joining Lauren at on the set of a Hills episode bring taped.