'''Original air date''': March 26, 2006

After a pregnancy scare, Lois urges Peter to get a vasectomy, which kills his sex drive and drives Lois to stuff herself with food. Meanwhile, Bertram (the sperm cell who fought with Stewie in "Emission Impossible") is born (from a lesbian couple who bought Peter's sperm at the sperm bank) and wages war with Stewie.
!!Tropes used in the episode:
* ArtisticLicenceHistory and BlackComedy: On the JFK assassination.
--> '''Lee Harvey Oswald''': Hey, Mr. President! Mr. President, up here! I voted for you. Wait a minute. That guy on the grassy knoll's got a gun. He's gonna shoot the President! Holy smokes, I've got to do something! (grabs a gun and aims it out the window) All right, Lee, time to become an American hero.
* BigEater: Lois becomes one when Peter refuses to have sex with her.
* ChubbyChaser: Peter's newfound attraction to Lois post-weight gain jump-starts their sex life.
* DoubleStandard: When Peter keeps criticizing Lois for her weight gain:
--> '''Lois''': You're one to talk. Look how fat ''you'' are!\\
'''Peter''': Lois, men aren't fat. Only fat ''women'' are fat.
* HypocriticalHumor: When Peter is apprehensive about getting a vasectomy, Joe tells him that a bunch of guys on the force got vasectomies and their lives haven't changed at all. However, he immediately shoots them down when asked if he would get one.
* LongList: Peter rattles off all the kids they have (except Meg), and a bunch that aren't.
--> '''Peter''': We can't afford another kid. We already got Chris, Stewie, [[Series/HappyDays Richie, Joanie]], [[Series/TheBradyBunch Greg, Marcia, Bobby, Jan]], [[Series/GrowingPains Mike Seaver, Carol Seaver, Boner]], [[Series/FamilyMatters Urkel]], [[Series/ThreesCompany Mr. Furley]].\\
'''Brian''': Peter, those aren't your kids. That's the Nick At Nite lineup.\\
'''Peter''': Blanka, Zangief, Chun-Li, Guile, E. Honda.\\
'''Brian''': That's [[VideoGame/StreetFighterII Street Fighter]].\\
'''Peter''': Red, blue, green.\\
'''Brian''': Those are colors.
* NotWhatItLooksLike: Subverted with the ending; when Peter is revealed to be in a closet making out with Lois's liposuctioned fat, he pauses for a minute, but when he can't think of an excuse, he says, "It's ''exactly'' what it looks like."
* RealityEnsues: Peter's desires to keep having fat sex with Lois turn out to be this. Her obesity ends up giving her a heart attack and she has to undergo liposuction treatment.
* ShoutOut: Stewie asks a kid on the playground, "You! [[Film/TheBluesBrothers You got my cheese whiz, boy?"]]
** Bertram says, [[Film/ANewHope "I sense something. A presence I've not felt since..."]]
* SuspiciouslySpecificDenial: At the sperm clinic, Peter accidentally knocked over a bunch of sperm vials, and when exiting the freezer later:
--> '''Peter''': (to nurse) And, uh, just so you know, everything in there is exactly the way it was when I went in. There is absolutely zero chance that I spilled all the jars and had to refill them with my own sperm. ''Zero'' chance.
* TakeThat: To the comic strip ComicStrip/{{BC}}.
* ToiletHumour: A cutaway involves Peter trying adult diapers.
* TheUnintelligible: Tony Danza and Sylvester Stallone in ''What?''.
* TruthInTelevision: A vasectomy is actually much safer and quicker than a tubal ligation (the female equivalent)--a vasectomy is also generally a lot cheaper.