"You feel guilty about everything."
"When we all lived in huts and wore furs, we worried over the simple things - food, water, whether animals would come and eat us in the night. Now we have supermarkets, bottled water and .38 caliber home security. So what keeps us awake at night? More often than not, guilt. If only I had acted differently... If only I hadn't said that... If only I had said something..."
"You beat yourself up with your past. Don't blame yourself, blame the world. Blame God. Blame me."
— Dr Kaufmann, Silent Hill: Shattered Memories
"Anyway, Darius is a Martian combat engineer with the biggest guilt complex this side of Olympus Mons. He's sent in to stop the cultists from destroying the terraforming machine that means they can all breathe - I'm guessing there's no intelligence test to get into this cult - but he fails and spends the next three years in a cave taking responsibility for some crazy guy's actions that he was trying to stop. Then the same crazy guy tricks him into unleashing a horde of murderous insect monsters on the people of Mars, and he accepts the guilt for that, too."
"You egotistical fucking prick, Darius Mason. I bet you take responsibility for the sun setting in the evening 'cause you didn't give it the proper encouragement."
"'You know, you really would make a good hero,' he said casually, as if he was continuing a conversation. 'Playing the blame game and losing every time is an integral part of the job.'"
— Kid Flash to Jinx, Life on the Offbeat by Re-Ane, a Teen Titans fanfiction
Neville: Do you have to do literally anything anyone asks you?
Harry: Do? No. Feel guilty about not doing? Yes. [...] Every time someone cries out in prayer and I can't answer, I feel guilty about not being God.
"Stupid conscience. I wish I could just give it up with a few magic words and live the rest of my life with no problems."
Mulder: I felt responsible for your death.
Deep Throat: You can let that go. Clearly, I'm alive.
Mulder: I thought that you died for my quest.
Deep Throat: Yes, along with Scully's sister and the man you thought was your father and Duane Barry and even Scully's mysterious illness and on and on and on. You can let go of all that guilt. I'm here to tell you that you're not the hub of the universe, the cause of life and death. We— you and I— we're... merely puppets in a master plan. No more, no less. You've suffered enough. Now you should enjoy your life.
— The X-Files, "The Sixth Extinction: Amor Fati"
Donna: His sister died in a fire while she was baby-sitting him. She tried to put it out, he ran outside. He went off campaigning, his father died. He wakes up in a hospital and discovers the President's been shot. He goes through every day worried that somebody he likes is going to die, and it's going to be his fault. What do you think makes him walk so fast? (walks towards some file cabinets) Anyway, when you looked at the list of replacements and said, "That's a windfall," what he heard was "Thank you Josh, you did it again. More for us."
— The West Wing, "Commencement"
"I should've done what I was told. I should've been more careful. I shouldn't have defied Mr. Kreel; that's why he did this to me."
— Dollface, reflecting on an incident when she accidentally spilled coffee and had a mask nailed to her face as a consequence. Twisted Metal