->'''Geralt''': You're clearly not human. What are you? A demon? A djinn?
->'''[[{{Satan}} O'Dimm]]''': Do you truly wish to know?
->'''Geralt''': Yes.
->'''O'Dimm''': No, Geralt, you don't. This one time I will spare you and not grant your wish. ''(...)'' All who have learned [[IKnowYourTrueName my true name]] are dead, mad, or both. [[PragmaticVillainy But I still need you.]]
-->--''Videogame/TheWitcher3WildHunt, Hearts of Stone''

->''"See, Lovecraft's stories haven't remained popular so long just because his monsters are scary. They endure because his monsters are metaphors for existential alienation. It's not the appearance of the monsters in his stories, it's the reality of them, the fact that they exist. Their existence alone proves that humanity is doomed and that all our hopes and dreams are stupid. Running into one of Lovecraft's Elder Gods is like finding a strange pair of underwear in your bed and realizing that your spouse is cheating on you. It's not the underwear itself that's stabbing you in the heart; it's the betrayal it represents. Lovecraft's monsters are proof to the protagonist that the universe is not benevolent. Finding strange underwear might mean that your spouse never loved you; stumbling upon a Lovecraft creature means that God never loved you."''
-->--''[[http://www.cracked.com/blog/5-types-movie-adaptations-that-must-be-stopped_p2/ 5 Types of Movie Adaptations That Must Be Stopped]] By C. Coville from [[http://www.cracked.com/ Cracked]]

->''"Please, Nabu, don't whisper too loudly. Don't show me what can be or not be. Fate is a fickle thing."''
-->--'''[[ComicBook/DoctorFate Kent Nelson]]''', ''{{Series/Smallville}}''

-> ''"Not knowing everything is all that makes it okay sometimes."''
-->-- '''Delirium''', ''ComicBook/TheSandman''

->''He holds out his hands and he touches the chest\\
He breaks its seals, he disturbs its rest\\
Curious and slow he opens the lid\\
He stares over the edge, what he sees he can't grip\\
No diamonds but he sees his own face\\
A possessed wreck with an empty gaze\\
Thrilled by madness he's dying in pain\\
No dream, he's insane!''
-->-- "Diamonds of the Black Chest" by '''Music/RunningWild'''

->''Thought For The Day: Be strong in your ignorance. Knowledge brings only suffering.''
-->-- ''TabletopGame/{{Warhammer 40000}}''

->''[[HeroicBSOD The metal lives. The metal lives. The metal lives. The metal lives.]] [[MadnessMantra The metal lives. The metal lives. The metal lives. The metal lives.]]'' '''''[[GoMadFromTheRevelation THE METAL LIVES. THE METAL LIVES. THE METAL LIVES. THE METAL LIVES...]]'''''
-->-- '''Magos Biologis Sharle Darvus''', artefact study notes, ''[[TabletopGame/{{Warhammer 40000}} Xenology]]''

->''"Poor [[ThirdPersonPerson Redvers]]... he was so frightened, his hair went completely white... he went quite mad, you know..."''
-->-- '''Redvers Fenn-Cooper,''' ''Series/DoctorWho'', "[[Recap/DoctorWhoS26E2GhostLight Ghost Light]]"

->''"I am confident that if anyone actually penetrates our facades, even the most perceptive would still be fundamentally unprepared for the truth of House Dimir."''
-->-- '''Szadek''' of the House Dimir, ''MagicTheGathering''

->'''Bart:''' We come now to the final and most terrifying painting of the evening. To even gaze upon it is to ''go mad!''\\
'''Homer:''' Aaah! [[http://en.wikipedia.org/wiki/Dogs_Playing_Poker They're dogs... and they're playing POKER!]] ''AAAAHHAHAHAHAHA!!''"
-->-- ''WesternAnimation/TheSimpsons'', "Treehouse Of Horror IV"

->''[[[TabletopGame/MageTheAwakening Paradox]]] then creates holes in the cosmos that hateful things of anti-existence crawl through. These hateful things then go rampant while the [[{{Muggles}} Sleepers]] are [[HeroicBSOD shutting down their mental processes]] because otherwise they have to deal with the idea that'' ''something just crawled through a '''hole in the cosmos.'''''
-->-- An RPG.net member discussing the dangers of [[WildMagic miscast spells]]

->''"Robo. I think I'm insane now.''"
-->-- '''Creator/CarlSagan''''s reaction to an EldritchAbomination, ''ComicBook/AtomicRobo''

->''"So after a filler episode where [[Series/PowerRangersTurbo they]] get baked into a giant pizza[[{{Beat}} .........]] Excuse me a moment."'' (walks away) "'''''[[TheScream AAAAAAAAAAAAAAAAAAHHHHHHHHH!!!!!]]'''''"
-->-- '''[[WebVideo/AtopTheFourthWall Linkara]]''', ''WebVideo/HistoryOfPowerRangers''

->''"When our people found a way to slip through the warp and prove another universe, an identical one, existed, it was too much for him. He could not live knowing that I lived. He became obsessed with the idea of destroying me. The fact that it meant his own destruction, and everything else, meant nothing to him."''
-->-- [[spoiler:'''Anti-Matter!Lazarus''', describing his evil Matter counterpart]], ''Series/StarTrekTheOriginalSeries'', "[[{{Recap/StarTrekS1E27TheAlternativeFactor}} The Alternative Factor]]"

->''"GOOOOOOOOOOOONE! It's all gone. All of it's gone! Bye-bye, woo hoo, see ya!"(...) "DON'T YOU GET IT?!? YOU SEE THE HAT?!? I AM [[PunctuatedForEmphasis MRS! NESBIT!]] [[LaughingMad BUAHAHAHAHAHAHAHAHA...!]]"''
-->-- '''Buzz Lightyear''', ''WesternAnimation/ToyStory'', when he finds out he really is a toy

->''"Sauranok, Sauranok. His own visions worked against him. Twilight's Hammer probably corrupted him from afar."''
-->-- '''Garrosh Hellsceam''', ''VideoGames/WorldOfWarcraft''

->''"Upon breaking out of his cryotube, an ecstatic Dr. Fuji tells Mewtwo that he is the end result of a scientific experiment to create an artificially enhanced cloned copy of Mew. Upon hearing this, Mewtwo takes the news rather well."''
->*Cuts to Mewtwo laying waste to the scientists and laboratory*
-->-- '''American Anime Otaku''' in his review of ''Anime/PokemonTheFirstMovie''

->'''Wiz:''' At first glance, this town appeared calm and peaceful, not worth a second look.\\
'''Boomstick:''' Until [[SelfDemonstrating/{{Sephiroth}} a sword-wielding goth guy]] found his alien mother hidden inside. [[GallowsHumor He celebrated with fireworks.]]
-->-- '''WebAnimation/DeathBattle''', describing the [[VideoGame/FinalFantasyVII Nibelheim Incident]]

->''In any event, the [[GiantSpider Weaver]] became excited by her new understanding, and began to weave more and more, furiously trying to overtake the Wyld so that [[ThePerfectionist its creation could be complete]]. The Wyrm was hard pressed to tear down what she had overbuilt. The Weaver became more and more upset that she could not complete [[MagicalUnderpinningsOfReality her Web]] without the Wyld changing it or the Wyrm destroying portions of it.''
->''Then the Weaver looked upon her web with her new eyes of awareness... and saw nothing. The marvelous, intricate patterns were meaningless. All she had been working towards, all she was... was nothing. Her newly conscious mind could not stand the enormity of her own useless work: she went [[MadGod mad]]. On she spun, in ever-widening patterns, disconnected from the rest of the Triat, heedless of any intervention.''
-->-- ''TabletopGame/WerewolfTheApocalypse - Book Of The Wyrm'' (1st Ed)

->Some seek the Void. [[BeCarefulWhatYouWishFor He found it]]. What he discovered, either through his arcane Arts or during a journey to the Upper Reaches - drove him utterly insane. Was he a sailor upon uncanny seas? Or a tower-bound astrologer who saw far too clearly through his telescopes? Perhaps he encountered the demon hordes through their bestial servitors... or maybe he's met them face-to-face on a [[CoolAirship Skyrigger]]'s decks. Either way, he has returned forever changed. He may act composed, but his soul is on fire for his [[EldritchAbomination demented, cthonic masters]].
-> Regardless of his trade, this wight is a rot-worm in the Daedalean foundations. He claims to serve reason, but [[TheMadHatter prefers its opposite instead]]. Like a tempter, he conceals his true allegiance behind a cloak of clever lies. Hidden in the halls of science, he drives wedges into the minds of other [[ScienceHero Daedaleans]]. At night, he leads mad ceremonies on barren hilltops, or screams himself hoarse in fits of secret ecstasy.
->Once, he called out for true Enlightenment. The answer he received raped his soul.
-->--Background notes for the '''Star-Ravaged Madman''' ''[[TabletopGame/MageTheAscension Mage: The Sorcerer's Crusade - Infernalism]]''

->Standing up, [She] began to expand at a phenomenal rate, the same grotesque metamorphosis that had occurred before repeating itself on a scale a thousand times grander. Those that saw this happen invariably ran screaming when they did not collapse into quivering, vomiting piles of mental trauma. Those that had the misfortune for [her] ghostly flesh to pass through them were left gibbering wrecks, their sanity violently and permanently ripped from them by the horrific experience.
-->-- ''Fanfic/ThousandShinji''

->That's right, I found a good ''Franchise/SpiderMan'' game! Better late than never! It's no ''masterpiece'' or anything like that, but it woulda definitely been worth a rental at the very least. Who made this game? ''[looks on the box, sees the [[Creator/LJNToys LJN]] [[ArchEnemy logo]], and drops the box in shock]'' Oh my God... ''Oh my God''... They did it... They pulled through! Oh my God! They made a game... that's ''not'' a steaming pile of fuckin' shit! OH MY GOD! THEY DID IIIIIT! THEY MADE A GAME! THAT'S NOT SHIT! ''[starts crying]'' I found the gold... at the end of the rainbow. Well, maybe it's not gold, maybe it's bronze or somethin', but... THEY MADE A GAME! THAT'S NOT SHIT! ''[SkywardScream] '''IT'S NOOOOT SHIIIIIT!'''''
-->-- ''WebVideo/TheAngryVideoGameNerd'' on ''Spider-Man & Venom: Maximum Carnage''

->It is sometimes an appropriate response to reality to go insane.
-->-- '''Creator/PhilipKDick''', [[SelfFulfillingProphecy who did just that]], ''{{Literature/VALIS}}''.

->'''Mary Stuart:''' It's a very small, very high-risk field, being a great occult mind.
->'''Catherine Stuart:''' Yes, they usually end up losing them to [[EldritchAbomination elder gods]] [[TheUnpronouncable with names like a mouthful of cornflakes]].

->[[OurAngelsAreDifferent Malak]], however, had driven much of his support team to [[EvilStoleMyFaith atheism]], [[DespairEventHorizon despair]] and [[DrivenToSuicide suicide]]. Not only was he clearly not connected to anything like God, but reportedly the [[HumanoidAbomination fucking thing]] would not stop [[BrownNote talking]].
-->--'''Reddin''', ''ComicBook/{{Supergod}}''

->'''The Doctor:''' As a novice, [the Master] was taken for initiation. He stood in front of [[NegativeSpaceWedgie the Untempered Schism]], that's a gap in the fabric of reality. Through which could be seen the whole of the Vortex. You stand there... Eight years old... Staring at the raw ''power'' of time and space -- just a child. Some would be inspired. Some would run away. And some would go mad. ''(exhales)'' I dunno.\\
'''Martha:''' What about you?\\
'''The Doctor:''' ''(matter-of-factly)'' Oh, the ones that ran away! I never ''stopped!''
-->-- ''Series/DoctorWho'', "The Sound of Drums"

->'''The Truth Burns'''
->One engineer [[LaughingMad begins to laugh]], seemingly unable to stop. Another [[BrokenTears weeps.]] The tears scorch his face like kettle-water. A third frantically tries to write down [[BrownNote what you said]], but gives up when her third pen [[AwesomenessIsVolatile combusts in lavender flame]]. "This changes everything," a grease-stained engineer whispers. Later, his colleagues catch him out back, burning his collected volumes of the ''Transactions of the South Wales Institute of Engineers.''