->''"You're listening to The Skeptic's Guide to the Universe;\\
your escape, to reality."''
-->-- '''Opening'''

''[[http://www.theskepticsguide.org/ The Skeptic's Guide to the Universe]]'' is the weekly {{Podcast}} of the New England Skeptical Society ([[http://www.theness.com/ NESS]]) in association with the James Randi Educational Foundation ([[http://www.randi.org/site/ JREF]]), hosted by Dr. Steven Novella, Robert Novella, Cara Santa Maria, Evan Bernstein, and Jay Novella[[note]]and formerly by Perry [=DeAngelis=], who passed away in 2007, and Rebecca Watson, who left the show amicably at the end of 2014[[/note]]. It is dedicated to covering the latest news on controversial claims, paranormal events, and fringe science, and they spend most of the show shedding light on whatever unscientific and illogical things they find while discussing events in the skeptical movement.

Not to be confused with ''Franchise/TheHitchhikersGuideToTheGalaxy'', though the podcast was named as a tribute to it.

[[FollowTheLeader Inspired the creation]] of the Podcast/{{Skeptoid}} podcast.

Contains examples of:
* BigfootSasquatchAndYeti: Unidentified animals and hoax monsters will occasionally pop up in the news, but no one on the show ever really takes them seriously.
* BriefAccentImitation: Almost everyone hosting has slipped into a British accent on occasion. Its also a "rule" that whenever a guest-host is serving as the Rogue for the week, they must do this at least once in the show.
* TheHost: There's Robert, Rebecca, Evan, and Jay, but its pretty obvious that Steven is the one in charge. He also hosts the ''Science or Fiction'' segment, while everyone else plays along.
* LeftItIn: The podcast started off very PG, as the host Steven Novella would edit out profanity. The show has gradually gotten more adult thanks in part to this trope.
** In particular when dealing with guests. Steve Novella almost never bleeps out profanity from a guest, no matter how bad, likely as a matter of principle.
* LogicalFallacies: The hosts spend most of their time on the show picking apart people's evidence and logic, and there is even the occasional ''Name That Logical Fallacy'' segment.
* LongRunner: Started way back in 2005, and still produced weekly to this day.
* OnceAnEpisode: There are many regular segments on the show: Who's That Noisy[[note]]A sound is played and listeners can write in trying to guess what it was[[/note]], What's the Word[[note]]The meaning of particular word is discussed in depth[[/note]], the Skeptical Quote, but most notably Science or Fiction, where one person (usually Steve) presents three (sometimes four) items, and the other rogues have to guess which one isn't real.
* ScienceHero: applies to everyone on the show, and a good number of the guests also. Being a part of the skeptical movement, the NESS has a hand in calling out unsafe medical practices, denouncing anti-vaccination protesters, stopping creationists from getting the upper hand in schools, disproving psychics, and have generally tried to become a force for change and for legislation that supports science.
* WittyBanter: There can be quite a bit. To quote Steve, the main tone of the show is to be "witty, but weighty".