While it was offscreen, the Firestarter Incident itself more than qualifies for this, with a third of Mustafu incinerated and thousands dead just because Izuku lost control of his quirk.
The sheer amount of HATE that Izuku and others can and have garnered merely due to their Quirks or accidents. To put into perspective, people were gunning for an elementary schooler so often that Pro Heroes had to set up shifts to keep Izuku safe.
Katsuki remembers when the Shie Hassaikai's Trash Trio once broke into the Bakugo home after being hired by one of the many grieving families to kill Izuku. From his accounts, Soramitsu Tabe had tried to EAT Izuku.
The Riddler, pulled straight out of The Batman (2022), is as unsettling and terrifying as he was there. And then there's the fact he wants Class Sanctuary to 'play his games'.
What the Riddler ended up doing to Uwabami to kill her. A deliberate homage to the Lust victim's death in Se7en, the Riddler mutilates Uwabami's vagina with a bladed strap-on. While a Gory Discretion Shot makes sure the event itself isn't shown, the state of Uwabami's corpse tells enough, her womb being completely eviscerated.
THE CABAL. They've only been mentioned once, but the idea of All For One having allies worldwide working with him toward a shared goal is terrifying. Never mind the fact that said members include the likes of Aizen and Belos.