Watch your step.
- As with the first movie, this film plays on people's instinctual fear of snakes—particularly ones large enough to consume human beings. Anyone with a phobia of snakes (or reptiles in general) who sees this film anyway should probably expect to have several nights that are either sleepless or nightmare-infested.
- While most of the CGI isn't that good, the scene where the characters are walking through the water and there's clearly a large yellow anaconda gliding between them is downright creepy, along with the cave scenes, which took advantage of Nothing Is Scarier.
- The first death is just as bad. Ben just seemingly vanishes as they cross the water. Suddenly he shoots above the surfaces, yanked around by an unseen force and begging for help. When he surfaces the final time he is badly bloodied, and everyone can only stare in horror as a snake drags him off.
- The stone spider, whose bite completely paralyses its victims, leaving them utterly helpless. Worse, the first time it bites someone is because someone else used it as a weapon.
- When the few survivors finally find the orchid, it's growing on a ledge just above a pit full of giant anacondas in a mating ball. And Jack, the only one with a weapon, forces the others to go down there and get it and just hope the snakes don't notice them.
- It's noted that all the anacondas they've seen so far are wandering males, searching out the much larger female. These were the smaller guys.
