As a LongRunner, ''WesternAnimation/SouthPark'' has a variety of memes attributed to it.
* "Oh my God! {{They killed Kenny|Again}}!" "You bastards!" [[labelnote:Explanation]]A RunningGag for the first five seasons where Kenny would get killed by something out of the blue, causing Stan and Kyle to react thusly.[[/labelnote]]
* "Derp" or "herp derp"; originally used by Creator/TreyParkerAndMattStone to describe lame, lowbrow comedy (as in the Creator/RobSchneider example), but has evolved on the Internet into a more general response to anything extraordinarily stupid or to [[CaptainObvious statements of the obvious]].
* [[ScrewThisImOuttaHere Screw you guys, I'm going home]].[[labelnote:Explanation]]One of Cartman's early catchphrases[[/labelnote]]
* BUT MOOOOOOOOM [[labelnote:Explanation]]Usually spelled BET MEEEEEEEM OR BIT MIIIIIIIM, after Cartman's odd accent[[/labelnote]]
** I am not "Myaeam".[[labelnote:Explanation]]Episode 1514, "The Poor Kid" where Cartman finally gets called out on his odd accent[[/labelnote]]
*** My name... is not... "Keeyle".
* Mr. Mackey's "m'kay" tic ("{{Drugs are bad}}, m'kay?").
* I'm super! Thanks for asking![[labelnote:Explanation]]Big Gay Al's catch phrase[[/labelnote]]
* "TIM-MAY!"[[labelnote:Explanation]]Most of what Timmy says is his own name.[[/labelnote]]
** Ooh, lib-a-lah!
* WELCOME TO SHITTY WOK [[labelnote:Explanation]]Greeting and catch phrase of AsianStoreOwner Tuong Lu Kim of City Wok.[[/labelnote]]

[[AC:Season One]]
* "You go to hell! You go to hell and you ''die!''" [[labelnote:Explanation]]Said by Mr. Hat in Episode 101 as a BigNo response to Kyle's request to go to the bathroom.[[/labelnote]]
** I'm gonna make love to ya, woman! I'm gonna lay ya down by the fiyah!
** "No, kitty. That is MAH pot pie."[[labelnote:Explanation]]Cartman yelling at Mr. Kitty when he begged for some of the pot pie[[/labelnote]]
* BEEFCAKE![[labelnote:Explanation]]Episode 102 "Weight Gain 4000"[[/labelnote]]

[[AC:Season Two]]
* "Respect mah authori-tah"[[labelnote:Explanation]]Episode 203: "Chickenlover". Cartman becomes a cop to fill in for Officer Barbrady. The quote has been used a few more times in the show's run[[/labelnote]]
* Phase 1: Collect Underpants, Phase 2: ?, [[MissingStepsPlan Phase 3: Profit]][[labelnote:Explanation]]Episode 217: "Gnomes"[[/labelnote]]

[[AC:Season Three]]
* I need about tree-fiddy.[[labelnote:Explanation]]Episode 303: The Succubus, where the boys tried to warn chef, but instead met his parents who keep telling about the times they met the Loch Ness Monster who kept on asking for "tree-fiddy" ($3.50). The stories start out pretty standard, but just keep getting weirder (the Loch Ness Monster disguises himself as a girl scout, pretends to be Chef's imaginary friend, and dresses up as an alien probing Chef's parent's anuses)[[/labelnote]]
* ...and that makes me a ''sad'' panda.[[labelnote:Explanation]]Episode 306, "Sexual Harassment Panda", wherein the eponymous panda [[TooSmartForStrangers attempts to teach the kids about being sexually harrassed]].[[/labelnote]]

[[AC:Season Five]]
* And if you think any of these aren't funny, then you need to get the sand out of your vagina.[[labelnote:Explanation]]Episode 502, "It Hits the Fan". Cartman thinks Kyle's being too uptight about people saying the word "shit" after hearing it on the TV show "Cop Drama".[[/labelnote]]
* Oh the tears of unfathomable sadness![[labelnote:Explanation]]Episode 504: "Scott Tenorman Must Die". After the ninth-grader Scott Tenorman humiliated Cartman while cheating him out of his money, Cartman exacted revenge by [[DisproportionateRetribution tricking Scott into eating his parents who had been murdered and mixed into the chili]], then licking his tears[[/labelnote]]
* Don't forget to bring a towel.[[labelnote:Explanation]]Episode 508, "Towelie". Catch phrases of the eponymous talking and toking towel.[[/labelnote]]
** [[TheStoner "Wanna get high?"]]

[[AC:Season Six]]
* Whatever! Whatever! I do what I want![[labelnote:Explanation]]Episode 603: "Freak Strike"[[/labelnote]]
* You're gonna have a bad time.[[labelnote:Explanation]]Episode 602, "Asspen", said by the ski instructor in regards to incorrect ways of skiing. Spun off into an Advice meme where if one thinks something outrageous/wrong, "you're gonna have a bad time".[[/labelnote]]
** The meme has since been referenced in ''VideoGame/{{Undertale}}'', in which the player [[spoiler:can attempt a KillEmAll run but will cause a key character to warn that the player is "gonna have a bad time" if they continue to kill everyone]].
* [[ItsBeenDone Simpsons did it!]] [[labelnote:Explanation]]Episode 607, "Simpsons Already Did It", when Butters-as-Professor-Chaos is constantly reminded that his schemes to rain misery upon the people of South Park sound [[ItsBeenDone very similar]] to old episodes of ''WesternAnimation/TheSimpsons''.[[/labelnote]]
* RABBLE RABBLE RABBLE!![[labelnote:Explanation]]Episode 611: "Child Abduction is Not Funny", where the town's citizens formed a frenzied crowd in front of the mayor's office in regards of what to do about the child abduction panic[[/labelnote]]
** DAMN MONGORIAN! STOP BREAKING DOWN MY SHITTY WALL![[labelnote:Explanation]]Tuong Lu Kim was entrusted by the town to build a wall around the down. It keeps being attacked by Mongolians.[[/labelnote]]
* [[NeverHeardThatOneBefore Derp de derp (de teetily tum)!]] [[labelnote:Explanation]]Episode 615: "The Biggest Douche in the Universe", from a parody trailer of a Rob Schneider film, which consists of almost nothing but variations of the word "derp".[[/labelnote]]

[[AC:Season Seven]]
* Craaaaaaaaaaab people, craaaaaaaaaaab people, taste like crab, talk like people...[[labelnote:Explanation]]Episode 708, "South Park is Gay". The marching chant of the Crab People, who disguised themselves as the cast of ''Series/QueerEyeForTheStraightGuy'' in order to make all of the males in South Park "metrosexual".[[/labelnote]]

[[AC:Season Eight]]
* "[[ Let's Fighting Love]]"[[labelnote:Explanation]]Episode 801: "Good Times with Weapons"[[/labelnote]], a parody of {{Engrish}} [[AnimeThemeSong anime theme songs]].
* "DEY TURK ER JERRRRRBS!" [[labelnote:Explanation]]Episode 807: "Goobacks". The people of South Park are angry that the immigrants from the future are willing to work for next to nothing, causing the more conservative townies to publicly voice their displeasure. An in-universe case, as well, as the phrase starts out as "They're taking our jobs", but through repeated use, degenerates into this. The episode "W.T.F." takes this even further.[[/labelnote]]

[[AC:Season Nine]]
* [[PoliticalCorrectnessGoneMad Oh, I'm sorry! I thought this was America!]] [[labelnote:Explanation]]Episode 905, "The Losing Edge". Randy says this every time he gets kicked out of Stan's little league games for starting fights in the stands.[[/labelnote]]
* '''[[IAmSpartacus I]]''' [[IAmSpartacus broke the dam!]][[labelnote:Explanation]]Episode 908 "Two Days After The Day After Tomorrow"[[/labelnote]]
* '''''GINGERVITIS!!!'''''[[labelnote:Explanation]]Episode 911 "Ginger Kids"[[/labelnote]]
* [[AC:This is what ([[ChurchOfHappyology X]]) [[NotMakingThisUpDisclaimer actually believe]].]] [[labelnote:Explanation]]Episode 912, "Trapped in the Closet". Used as part of a TakeThat when explaining the tenets of the Church, most of which are indeed accurate. Later reused in Episode 1001: "The Return of Chef", replacing the Church with the more lawyer-friendly "Super Adventure Club".[[/labelnote]]

[[AC:Season Ten]]
* "[[DepartmentOfRedundancyDepartment If we’re still alive in the morning, then we’ll know we’re not dead.]]"[[labelnote:Explanation]]Episode 1003: "Cartoon Wars Part I"[[/labelnote]]
* [=ManBearPig=] is very real and he most certainly exists....[[ I'm sereal, you guys! I'm super sereal!]][[labelnote:Explanation]]Episode 1006, "[=ManBearPig=]". Al Gore is dead serious about the existence of Manbearpig, an analog for global warming.[[/labelnote]]
* "[[ApocalypseHow Gentlemen, this could very well lead to the end of the world...]] [[WorldOfWarcraft of Warcraft]]". [[labelnote:Explanation]]Episode 1008 "Make Love Not Warcraft". When Creator/BlizzardEntertainment realizes people will stop playing because a {{griefer}} is killing everyones' character.[[/labelnote]]
* "Niiiiiice!"[[labelnote:Explanation]]Episode 1010, "Miss Teacher Bangs a Boy". The police officers say this about Ike (a ''[[RefugeInAudacity preschooler]]!'') when it's learned that he's been involved in a TeacherStudentRomance.[[/labelnote]]
* "Retard alert! Retard alert!" [[labelnote:Explanation]]Episode 1012, "Go God Go"[[/labelnote]]

[[AC:Season Eleven]]
* After Episode 1113: "Guitar Queer-O", any ''VideoGame/GuitarHero'' vid on Youtube that shows someone getting to one million points will be invariably showered with comments saying "YOU ARE FAGS!".

[[AC:Season Twelve]]
* "FUCK YOU, JIMMY BUFFETT! YOU FUCKING SUCK!" [[labelnote:Explanation]]Episode 1201, "Tonsil Trouble". Cartman hates Jimmy Buffett, who shows up at his AIDS benefit instead of Elton John.[[/labelnote]]
* [[ "I'm not your friend, buddy!"]] "I'm not your buddy, guy!" "He's not your guy, friend!" "I'm! not! your! friend! buddy!" [[OverlyLongGag "We're not your buddies, guy!"]] [[PunctuatedForEmphasis "IIIII'M! NOOOOOT! YOOOOOUUURRR! GUUUUUUY! FRIIIIIEND!"]] [[labelnote:Explanation]]Episode 1204, "Canada on Strike!"[[/labelnote]]
* Kenny's dance from "Pandemic".

[[AC:Season Thirteen]]
* Aaaaaaaaaand it's gone![[labelnote:Explanation]]Episode 1303, "Margaritaville". A banker says this after everyone in the bank starts losing their money. It can easily translate itself to many situations.[[/labelnote]]
* So I heard you like fish sticks...[[labelnote:Explanation]]Episode 1305: "Fishsticks"[[/labelnote]]
** Music/KanyeWest is not a gay fish!
* "'''''[[ FUCKA YOU WHARU!!! ANDA FUCKA YOU DOROPHEEEN!!!]]'''''"[[labelnote:Explanation]]Episode 1311, "Whale Whores"[[/labelnote]]

[[AC:Season Fourteen]]
* Shut up, [[AcceptableHardLuckTargets Mimsy]]![[labelnote:Explanation]]Episode 1407: "Crippled Summer"[[/labelnote]]
* Captain Hindsight[[labelnote:Explanation]]Episode 1411: "Coon 2: Hindight". A superhero who comes to a scene of a catastrophe and only says what would have been done to avert it. It eventually caught on, with an imageboard meme inspired by it much like the ski instructor above.[[/labelnote]]
* Mint-Berry Crunch.

[[AC:Season Sixteen]]
* "Oooh, long Johnson! Oooooh, looong John--''*get hit by train*''[[labelnote:Explanation]]Episode 1603, "Faith Hilling", where the episode spoofs the act of memeing[[/labelnote]]
* Jackin' it in San Diego![[labelnote:Explanation]]Episode 1605, "Butterballs". A RunningGag turns into GainaxEnding and an EarWorm[[/labelnote]]

[[AC:Season Seventeen]]
* Boo! Wendy! Boo! [[labelnote:Explanation]]Episode 1702, "Informative Murder Porn"[[/labelnote]]
* Brack Friday Bunduru [[labelnote:Explanation]]Episode 1707, "Black Friday"[[/labelnote]]
** KISS MAH FAT VAGINA! [[labelnote:Explanation]]Said by a morbidly obese, rascal-riding redneck lady, voiced by Trey Parker doing the manliest voice he can.[[/labelnote]]

[[AC:Season Eighteen]]
* I am Music/{{Lorde}}, ya ya ya! [[labelnote:Explanation]]Episode 1803, "The Cissy", which carries the theme of Randy Marsh's being the pop star Lorde.[[/labelnote]]

[[AC:Season Nineteen]]
* You PC, bro?[[labelnote:Explanation]]Episode 1901, "Stunning and Brave", where the parents met at a college bar that somehow popped up in South Park, and a few of the waiting staff approached the parents when they presume trouble over the mention of Caitlyn Jenner before noticing each other and asking about their own affiliations, even going as far as forming a PC fraternity.[[/labelnote]]
* Buckle up, buckaroos![[labelnote:Explanation]]Episode 1902, "Where My Country Gone?", with a RunningGag involving Caitlyn Jenner giving people a ride and immediately running people over, in reference to the vehicular manslaughter prior to Bruce Jenner announcing himself as Caitlyn.[[/labelnote]]
* Enjoy your Boogers and Cum![[labelnote:Explanation]]Episode 1904, "You're Not Yelping", the restaurant owners ultimate and [[Awesome/SouthPark awesome]] revenge on self-important Yelpers.[[/labelnote]]

[[AC:Season Twenty]]
* "Member _____?" "Oh, I member!"[[labelnote:Explanation]]Episode 2001, "Member Berries", with aforementioned berries saying them. Typically something nostalgic, though towards the end of the episode [[spoiler:not all are positive]][[/labelnote]]
* [=Skankhunt42=] has now become the username of several Twitter users.
* "I am in a PC pretzel here."[[labelnote:Explanation]]Episode 2004, "Wieners Out", when PC Principal explains to the girls that he can't take sides during the conflict between the boys and girls because reprimanding the boys for exposing their genitalia in response to the girls' protest would also not be politically correct[[/labelnote]]
* Associating the songs "[[Music/MelanieMartinez Pacify Her]]" or "[[WesternAnimation/StevenUniverse It's Over, Isn't It?]]" with Kyle. [[labelnote:Explanation]]Kyle seems to be jealous of [[spoiler:Cartman and Heidi's relationship, and he misses Cartman]]; the former song is about a girl whose lover moved on with another in her absence and she can't get over it, and the latter is about Pearl expressing her unrequited love for Rose and how she was upset when she ultimately chose Greg.[[/labelnote]]
* Kyle is jelly. [[labelnote:Explanation]]A CallBack to the episode "The Hobbit", fans like to describe Kyle as "jelly" in regards to [[spoiler:Heidi and Cartman being together]].[[/labelnote]]
* Due to the fact that Craig brought a knife to [[spoiler: help the other boys destroy Cartman's electronics [[labelnote:Note]] and the other boys bring more sensible weapons, such as hammers or axes[[/labelnote]] ]] which would be largely ineffective for its intended purpose, it's become a meme to half-jokingly theorize that Craig thought that the plan was to actually murder [[spoiler: Cartman.]]

[[AC: Season Twenty-One]]
* "Heidi deserves better!"[[labelnote:Explanation]] Cartman behaving like a [[BastardBoyfriend complete jerk towards Heidi,]] along with Heidi trying to understand where Eric's anger is coming from and make the relationship work has made Heidi a major [[TheWoobie woobie]] for the fandom. [[/labelnote]]

[[AC:[[WesternAnimation/SouthParkBiggerLongerAndUncut The Movie]]]]
* "Fucking Windows '98!" [[labelnote:Explanation]]From the movie where Saddam Hussein possesses the computer used by the U.S. Military for their invasion of Canada, causing the general to exclaim the quote.[[/labelnote]]
* ''[[VillainSong Some people say, that I'm a bad guy...]]''