[[caption-width-right:200:The main cast.[[note]]Clockwise: [[PatientChildhoodLoveInterest Ami]], [[UnluckyEverydude Junta]], [[FishOutOfTemporalWater Karin]], [[JerkJock Ryuuji]], [[ShrinkingViolet Kotomi]] and [[TheTease Tomoko]][[/note]]]]

In the future, the world's overpopulation problem is traced back to [[OrdinaryHighSchoolStudent Junta Momonari]] and his [[ThePornomancer supernatural ability to seduce women]], which gains him the title of "Mega Playboy". Though you'd never know it, since currently Junta's powers have not woken up, and he's just your typical UnluckyEverydude with a ''literal'' allergy to women... that causes him to throw up whenever he sees a naked girl that isn't his mother. Which happens in front of Tomoko Saeki, the most beautiful girl at his school.

Right after this hilariously horrible incident, an ActionGirl named Karin Aoi [[SetRightWhatOnceWentWrong travels back in time]] to "assassinate" his ability by [[AwesomeButImpractical shooting him]] (non-lethally) with a special bullet that alters his [[TitleDrop DNA]] before his powers as Mega Playboy come to the surface... Unfortunately, she accidentally used a bullet she personally customized to create a "perfect husband" - causing Junta's powers to not only awaken, but be exponentially stronger.

Now [[HilarityEnsues Karin has to find him another way to control Junta's powers, or face the death penalty]]. While waiting for new orders from her superiors, she stays at Junta's home to keep a watch on him and learn about his environment (and the girls who could be affected, like Tomoko), and then she meets Ami Kurimoto, Junta's UnluckyChildhoodFriend who is the ''only'' girl who is immune to the Mega Playboy's charm. Now she has to see what to do before Junta breaks havoc among the female populace!

Originally a short-lived early 1990s manga by Creator/MasakazuKatsura (the same author as ''Manga/VideoGirlAi''), later adapted into a TwelveEpisodeAnime. Its plot and characters also formed the basis of a famous {{Website/Newgrounds}} DatingSim called ''[=SimGirls=]''.
!!''DNA[[superscript:2]]'' provides examples of the following tropes:

* ActionGirl: Karin; Rurara
* AnimeHair: Junta, to the ridiculous level of spiky hair.
* AttemptedRape: When Kotomi and Junta end up in a redlight district, Junta gets knocked out and two guys drag Kotomi into a back alley, intending to rape her in turn. Junta fortunately wakes up in time and uses his telekinetic powers to send them away.
* BabiesEverAfter: Implied to have been the case between [[spoiler: Junta and Karin, had Mori not come back to prevent exactly that from happening. According to Mori, Karin and Junta would have a son three years after the time she originally came to the past and that it was the only true love Junta Momonari had after the Mega Playboy awakened, and the two were even married]].
* BitchInSheepsClothing: Tomoko initially comes off as this, but she's actually [[ParentalAbandonment incredibly]] [[LonelyRichKid lonely]] to the point of being a Woobie.
* BlasphemousBoast: Karin pulls one off during her first appearance.
--> '''Karin:''' Not even God can interfere with the flow of time.
* BlindIdiotTranslation: A very odd and annoying one happens in the Mexican Spanish translation of the manga, and also overlaps with ViewersAreMorons, since unlike other examples, this is ''enforced'' by the publishers: Basically, any character with name who use the letter "J" (Junta, Ryuji, etc) is written with "Y" (Yunta, Ryuyi, etc) since the publishers thought the Mexican readers could not be able to pronounce those names right.[[note]]This is sort of justified, as ''Junta'' pronounced phonetically in Spanish (Hoon-tah) sounds the same as the Spanish word for "council" or "reunion".[[/note]] The European Spanish translation, who was translated a few years previously before the Mexican one, avoids this.
* BroughtDownToNormal: [[spoiler: In the end, Karin shoots Junta with the right DMC, erasing the Mega Playboy DNA within him, meaning he is now no more attractive than his UnluckyEveryDude persona was originally.]]
* CallingYourAttacks: Junta gives his attacks when fighting names, all with the Mega Playboy theme to them. There is the Mega Play Chop, the Mega Play [[GroinAttack Elbow]], Mega Play Final Crusher and the Mega Play [[KamehameHadoken Cannon]]. Ryuuji creates a strong attack that he simply calls the Super Sonic Attack.
* DisappearedDad: Junta's father died when he was young, so he was raised only by his ApronMatron mother Chiyo. Tomoko's dad works outside of Japan.
* DisproportionateRetribution: Before Karin actually intervenes and is merely observing Junta, she sees how he overhears Tomoko admitting to Ryuuji that she wasn't cheating on him, but merely picked up a loser to tease. Karin wonders whether being made fun of by pretty women was the reason for Junta to turn into a Mega Playboy. [[spoiler: According to Mori, though, the Mega Playboy would have awoken inside Junta at the age of 21, regardless of what happened, so it's unlikely that this was the reason.]]
* EasilyForgiven: Tomoko, to her {{Jerkass}} boyfriend Ryuuji.
* EstablishingCharacterMoment: Karin is introduced by stepping out of her time ship, her face obscured by her clothes and surrounded by mist, says a BlasphemousBoast and proceeds to [[{{Squee}} squee]] over her own awesomeness.
--> '''Karin:''' Not even God can interfere with the flow of time. ({{Beat}}) That was ''so cool''!
* {{Fandisservice}}: There's a scene of Ryuji [[spoiler: with the body of Tomoko, wearing girls' underwear, in front of a mirror]] and talking about how much he loves and misses Tomoko... and it's quite a disturbing sight to see.
** There's an earlier scene of Ryuji [[spoiler: with Tomoko's face and groping his ass, saying he ''knew'' Tomoko had a nice one, proceeds to undress to "take in the view" and realizes it's his ''own'' body]], though the naughty bits are covered with a mosaic filter.
* {{Fartillery}}: Kotomi's... biggest problem, shall we say. She farts when she gets nervous, and since she's a gym practitioner... It should be noted that her farts in the manga seem to venture more toward {{Fartillery}} territory than the anime; in the anime, her farts are average sounding but in the manga they're often ''drawn like explosions'' to emphasize their volume.
* GassHole: As mentioned above, poor Kotomi's disorder turns her into this when she gets nervous (which happens quite frequently) making her one of the [[RareFemaleExample rare female]] [[GassHole gassholes]] in fiction.
* {{Gonk}}: Ryuuji when he [[http://www.mangareader.net/1353-44630-13/dna2/chapter-21.html uses parts of all the DNA he absorbed]] is not a pretty sight to look at.
* ImportantHaircut: Kotomi has GirlishPigtails, which she later trades for a cute pageboy style.
* InSeriesNickname: Junta Momonari begins to refer to his playboy personalities via nicknames. The one full of {{BishieSparkle}}s but with no ability to fight is referred to as "Twinkle Junta" and the proper Mega Playboy with fighting capabilities is the Mega Playboy himself. [[spoiler: When the Mega Playboy is forcefully brought out in the final chapters and is a huge asshole, Junta calls him a devil and Mori says, "Very fitting. We'll call him Devil Junta", though the Mega Playboy does not like that.]]
* {{Jerkass}}: Ryuuji. Even ''more'' after [[spoiler: he gets shot by Karin by mistake, too, and gains powers from that.]]
* KarmaHoudini: Okay, so [[spoiler:Ryuuji ends up in the hospital and then gets BrainwashedAndCrazy]]... but what about [[spoiler:the several cases of attempted murder along with attempted rape]]?!
* LastMinuteHookUp: [[spoiler: Junta and Ami. All the other potential rivals are taken care of since Tomoko has [[EasilyForgiven forgiven]] Ryuuji for his constant cheating ''and'' stalker attitude and is taking him back, Kotomi has been PutOnABus to Germany and Karin removes Junta's memories of her and returns to the future.]]
* LawOfChromaticSuperiority: Inverted. Junta Momonari has pretty dark hair, often depicted with red for highlights, where as Twinkle Junta has slightly spikier and lighter hair. Both are outdone by the Mega Playboy, who can charm women much faster and easier ''and'' is a much better physical and telekinetical fighter than either of them, and he's shown to have much brighter hair than either of them, going into a neon-magenta color.
* LonelyRichKid: Tomoko's FreudianExcuse. Not only her dad is a very rich businessman who spends more time abroad than with his only daughter, but her mom is dead.
* ManlyTears: Junta sports some after he lands a huge punch onto Ryuuji and thinks he won the duel. [[spoiler: He hasn't.]]
* NearRapeExperience: When Junta [[spoiler: actually Ryuji who took on the appearance of Junta]] tries to force Ami to sleep with him, she demands to know if he wants to sleep with ''her'' or just wants to have sex. Saying it could be any girl, Ami stops resisting and tells him that their friendship is '''over''' then... and he stops, suddenly not feeling like it anymore. [[spoiler: It does lead Ryuji to discover that he can simply absorb a person's DNA by touch and be capable of taking on their full-body appearance then.]]
* NoBadassToHisValet: Why Ami is the only known female actually immune to Junta's Mega Playboy persona.
* TheOjou: Tomoko
* OperationJealousy: Tomoko once asked Junta to go out with her to make Ryuuji jealous after a big fight. And it's right after the horrible (and hilarious) consequences that Karin comes in...
* PlotHole: Rurara's existence is both this and a time paradox. [[spoiler:First, Karin tells Junta that Mega Playboy only fathered sons and the trend continued down the line of only sons. Then, after the Mega Playboy gene is removed from Junta, Rurara doesn't disappear. The only logical explanation for this is that she was either his descendant through Ami or that being descended from Mega Playboy was a bluff.]]
** Adverted in the manga, where she ''does'' dissappear.
* PopulationControl: Due to overpopulation in the future, there's a strict law that permits people to only have one child. Since Junta was a Mega Playboy and fathered ''100 children'', who all have the same, charming and potent DNA, the plot begins by sending someone back in time to change his DNA so that he won't father those children as a simple and fast way to control the issue.
* ThePornomancer: Junta is supposed to grow into this and the Mega Playboy ''is'' one. And Ryuji ''thinks'' he is one.
* SexyShirtSwitch: Subverted. When Junta wakes up at morning, he finds Karin sleeping on a ''futon'' wearing one of his shirts and her panties... but since Junta is ''literally'' allergic to girls, there is NO way something could've happened. Karin was wearing his shirt just because Junta's mother Chiyo put it on her when she was passed out.
* ShipTease / WillTheyOrWontThey: Junta falls for Karin pretty early on, and her wacky inner monologue reveals that she likes him even [[SingleWomanSeeksGoodMan when he's not radiating distilled sexuality.]]
** [[spoiler:Either DownerEnding or BittersweetEnding]]: [[spoiler:In the manga, Karin seriously considers staying in the present with Junta, but when she realizes he's started to truly like [[VictoriousChildhoodFriend Ami]] after all, she tells him that him liking her "too" is not good enough to face all the risks that come with staying, and says goodbye, Junta, of course, tries to stop her, but she still goes to the future and he still gets shot with a bullet that takes away all the awesome powers he recently got complete control over, and his memories of everything that happened in the story.]]
** The anime omits all of this. [[GeckoEnding Instead]], [[spoiler:she just tells Junta to be happy with Ami, and departs with a smile, leaving him fairly heartbroken.]] The [=OAVs=] give a little more closure: [[spoiler:after Mori is captured and Rurara is "defused", Karin again shoots Junta... but with a bullet that will both undo the MPB traits ''and erase his memories''. Ami ''does'' beg her to reconsider it, asking Karin if that's really the best course of action, and Karin replies that it can't be really helped since she's from the future, [[ButNowIMustGo her mission is fully complete]], and [[StarCrossedLovers there wouldn't be a way for them to really get together]]. [[CryCute She even cries as she explains this to Ami]], who then accepts it and promises to make Junta happy; then Karin, Rurara, and the other people from the future return home]]. Still Gecko, but makes a little more sense.
* ShoutOut: Mega Playboy mode Junta is very obviously based on the hair Gohan sported in ''Anime/DragonBallZ'' once he hit Super Saiyan level 2. Justified, as Masakazu Katsura is a personal friend of Akira Toriyama and both authors love to throw jabs at each other on their respective works.
** When Junta comes down from his first transformation into the playboy personality, he thinks he's cured and grabs dirty magazines to prove that he can look at half-naked girls without vomiting. There are two magazines, one with Ai and the other with Mai on it. Both are from Masakazu's previous manga ''Manga/VideoGirlAi''.
* {{Tsundere}}: ''Both'' Karin (Type B) and Ami (Type A).
* VomitDiscretionShot: Junta vomits on-screen whenever he's near women, even in the opening credits!