A Psychedelic Comedy Bromance is a {{Duo Trope|s}} that results from an OddCouple or other ComedicDuo acting as the protagonists in a world where they are likely to come across HighWeirdness, CosmicHorror, or other trippy or terrifying happenings. This could be a HighFantasy setting, but it is often just a version of the ordinary world where supernatural, highly improbable, or otherwise wild things just happen to happen. The duo contends with the weirdness as best they know how. They may both be seriously endangered when reality goes on the fritz, or the StraightMan may not be able to cope with the oddities and lets the LovableRogue deal with it, though they may be an AdventureDuo who are well-equipped to handle the situation.

Notable examples:



[[folder: Literature]]
* ''Literature/TheHitchHikersGuideToTheGalaxy'' has this dynamic between Arthur and Ford for much of the series.
* ''JohnDiesAtTheEnd''

* ''Series/TheMightyBoosh'': Effete day-glo David Bowie-lookalike Vince Noir and perpetual sad-sack jazz musician Howard Moon journey to the arctic, the planet Xooberon, and monkey hell -- which all strongly resemble [=BBC=] soundstages -- while bickering like an old married couple.
* Coming from two supporting actors in the above mentioned ''The Mighty Boosh'', it's no surprise ''Series/SnuffBox'' has this trope as well. Matt Berry is "High Execution to the King of England" [[note]] ''in 2006, England had neither capital punishment nor a king'' [[/note]] and Rich Fulcher is his assistant, a boorish American. Together, they wander through a very loosely related string of infinitely dark and morbid skits, while defying every known trope of comedy and good taste.

[[folder: Western Animation]]
* WesternAnimation/AdventureTime
* WesternAnimation/RegularShow
* WebAnimation/DickFigures
* In the ''Franchise/EverAfterHigh'' series, minor characters Alistair and Bunny spend their lives exploring [[Literature/AliceInWonderland Wonderland]] together. Only occasionally do they show up in the main plot- usually to guide the protagonists through Wonderland's illogical and ever-changing landscape.