->''"They're never curing AIDS. There's no money in the cure. The money's in the medicine. That's how you get paid, on the comeback. That's how a drug dealer makes money, on the ''comeback''...You think they're gonna cure AIDS? They're still mad about all the money they lost on Polio!"''
-->-- '''Creator/ChrisRock'''

This plan involves unleashing some kind of poison or plague and then either selling the antidote or cure (typically at an exorbitant price) or blackmailing a person into working for them in order to get it.

Subtrope of FindTheCure. Not to be confused with simply CarryingTheAntidote. SisterTrope to MonsterProtectionRacket. Has nothing to do with PoisonedChaliceSwitcheroo.


[[folder:{{Anime}} and {{Manga}}]]
* Attempted in the 2001 ''Manga/{{Cyborg 009}}'' series. The Egypt episode had a bunch of villains whose plan culminated in dropping a bomb filled with poison into Cairo, while the team and ''specially'' [[TheHeart Francoise]] (who is in full ItsPersonal mode, and [[SuperSenses has the perfect powers]] [[WrenchWench to defuse the crisis]]) attempted to defuse it.
* In ''Manga/BusouRenkin'', [[EvilGenius Papillon]] tries a variation on this. Having planted a Homunculus embryo in [[TheLancer Tokiko]], when [[TheHero Kazuki]] confronts him, Papillon offers a cure in exchange for Kazuki's [[MacGuffin Kakugane]]. This could also overlap a bit with an unintentional XanatosGambit, given that the cure [[spoiler: is a useless fake]] - if Kazuki makes the trade, then Papillon gets to study Kakugane technology and he ''still'' gets to turn one of his greatest enemies (at the time) into a minion. If not, then he loses out on the Kakugane... ''but still gets Tokiko as a minion''. However, because the Kakugane is what brought Kazuki BackFromTheDead, he can't remove it or he'll die. [[spoiler: Kazuki can't make the trade and accidentally knocks out Papillon with one punch, at which point Tokiko arrives and tells him that the cure was fake.]]
* In the ''Franchise/EvilliousChronicles'' franchise this is the plan of [[spoiler:Père Noël]] in ''LightNovel/GiftFromThePrincessWhoBroughtSleep'', having [[spoiler:Margarita make an airborne toxin of Gift]] and selling the cure on the black market. The only problem is that [[spoiler:Margarita wanted to just kill everyone with the poison.]]
* In a chapter of the ''Manga/RurouniKenshin'' reboot, a corrupt doctor acquired a vial of smallpox and intended to infect a town with it so he could make money curing them. Fortunately, Kenshin, a good doctor, and a cart driver were able to stop him.
* In Chapter 22 of ''LightNovel/TheRisingOfTheShieldHero'', Naofumi poisons a guard, who he then tells will die unless he receives an antidote from him. He uses it to turn the guard into a guide to find Melty.
* In ''Anime/NinjaScroll'' Dakuan (a spy for the Tokugawa government) forcibly recruits MasterSwordsman Jubei to help him prevent a group of super ninjas from completing a scheme that would help overthrow the government by making use of this trope. Jubei has already had several run-ins with the ninjas in question, but declines to help Dakuan is about to [[ScrewThisImOuttaHere simply walk away from the whole situation]] when Dakuan reveals that [[StockNinjaWeaponry a shuriken]] that Dakuan used on Jubei earlier was poisoned, and Jubei will die within days unless he helps Dakuan.

* In the ''[[Comicbook/ThePunisherMAX Punisher MAX]]'' storyline "6 Hours to Kill", Frank is blackmailed with a cure to assassinate someone. He instead decides to take down as many criminals as possible before dying.
* German comic ''ComicBook/FixUndFoxi'' had the (mostly) LovableRogue Lupo pull this off once. First, he let loose a lot of moths and sold people a spray against them. From said spray, people got an allergic reaction and had to sneeze all the time. He sold them a cure - which made people unbelievable thirsty. Fortunately he sold them a special lemonade which would cure their thirst - but totally mess up their hair. Then he sold them wigs. Which were badly made, with the hair falling out. Then finally, they got it. Cue the mob.
* A heroic trickster variation. In an issue of ComicBook/MarvelStarWars, Luke told an imperial officer he had poisoned him, and would give him the antidote once he gave Luke access to computer records. Feeling stomach pains, the officer complied, and then Chewbacca knocked him out. Turns out Luke only put soap flakes in the officer's soup.
* In ''Comicbook/RedSonja'' the thought-to-be-deceased King of Zamora is revealed to have created a "plague" (actually a poison) that he gave to his enemies in order to trick Sonja's former companion Annisia into massacring entire cities, believing them to be infected, while he holds the antidote.

* This happens in the live action ''Manga/BlackButler'' movie, with a poison that causes mummification.
* ''M:i'' films
** This was the Big Bad's plan in ''Film/MissionImpossibleIII''.
** And in ''Film/MissionImpossibleII'', it was more subtle than that: The BigBad wanted stock-options of a company he sold the antidote to, allowing him to get his share when said company made big bucks.
* ''Film/VForVendetta'': The Norsefire group get their position by spreading a plague through several areas, and blaming it on supposed captured terrorists, and its leader Sulter won the election by a landslide, the party then distributes a cure through a medical company they control.
* ''Film/IndianaJonesAndTheTempleOfDoom'' involves a one-person version of this trope in the ColdOpen where Indiana is tricked into drinking poison. "And now doctor Jones, you give me the diamond."
* In ''Film/EscapeFromLA'', Snake is infected with the Plutoxin 7 virus, which will kill him in 10 hours unless he gets the President's daughter and the {{EMP}} satellite control device she stole. Subverted in that [[spoiler: at the end, it's revealed that "Plutoxin 7" is merely a fast-acting, hard-hitting case of... the flu]].
* In ''Film/SecretAgentSuperDragon'', the BigBad used this to coerce some spies to turn DoubleAgent. Of course, being the Big Bad, he never got around to giving those he turned the antidote.
* The villain of the Matt [=McColm=] action movie ''Body Armor'' creates nasty viruses and makes money off them by then selling the cure.
* In ''Film/{{Ultraviolet}}'', BigBad Daxus plans to unleash a plague targeting humans, to which he has the cure. This is because hemophages are nearly extinct, and he needs a new plague to justify the Arch-Ministry's continued existence.
* The film ''Film/PhaseIV2002'' turns out to have this as the motive for the murders: [[spoiler:A pharmaceutical company murders everyone who knows they've created a cure for AIDS.]]
* ''Film/TeenageMutantNinjaTurtles2014'': What Shredder and Eric Sacks's EvilPlan amounts to; they will unleash a lethal biotoxin upon New York City, and then profit from selling an antidote derived from mutagen extracted from the Turtles' blood.

* Creator/EmoPhillips told a joke in which as a child, he had a lemonade stand where the first glass was free and the second was $5. The second glass contained the antidote.
* A group of tourists goes on a guided tour of a rubber factory. First they see the floor dedicated to baby pacifiers, then the floor dedicated to condoms. One tourist notices that one in ten condoms is removed from the assembly line, goes through a separate machine, then gets put back with the rest. On asking, he is told that the machine pokes a hole in the condoms that go through it. After all, they've got to sell pacifiers somehow.

* In Creator/LoisMcMasterBujold's ''[[Literature/VorkosiganSaga Vorkosigan]]'' series, Baron Fell of Jackson's Whole has this as the basis of most of his business, selling both traditional military weaponry and their defenses, as well as manufacturing chemical and biological weapons along with their cures.
* An ImpliedTrope in Steinbeck's ''Literature/ThePearl''. After being stung by the scorpion, Coyotito seems fine until the doctor gives him a pill and says he thinks the poison will hit within an hour. Sure enough it does and the doctor then cures him. Even the uneducated Kino is very suspicious.
* A variation occurs in John Collier's famous story ''The Chaser'': TheLittleShopThatWasntThereYesterday sells a LovePotion for a pittance which the owner strongly implies will turn the main character's beloved into a LoveFreak. The antidote in this case is the "chaser" of the title, which is some sort of poison to "solve" that problem.
* Thomas of Magnus, the ''hero'' of Sigmund Brouwer's ''Literature/{{Wings of Dawn}}'', uses this -- the price of being given regular doses of antidote is continued cooperation from the [[AncientConspiracy agents]] pursuing him, all of whom claim to be with the good guys and want him to join them. [[spoiler: In reality, this is a BatmanGambit to weed out which side is lying; Knowing that the villains have [[CombatPragmatist fewer compunctions about fighting dirty]] and [[OutGambitted think they're smarter than he is]], Thomas is slipping non-lethal doses into every meal and providing them with flavored water as the "antidote". When he "inadvertently" allows them enough information to determine the recipe of the supposed antidote, the villain works it out and seizes the opportunity to... [[HoistByHisOwnPetard poison himself]]. OOPS]].
* In ''Literature/TheDresdenFiles'', Harry pulls a unique subversion by poisoning HIMSELF so that he can [[StopOrIShootMyself strong-arm a faerie with an interest in his survival]] into cooperating with his plan.
* In ''Literature/InheritanceCycle'' this gambit is used to ensure that Arya couldn't escape prison, as only her captors had the antidote.
* The [[MegaCorp Corporations]] of ''Literature/OryxAndCrake'', particularly [=HelthWyzer=], made a business out of creating new diseases, inserting them into their vitamin supplements, and then selling the proprietary cures at high prices. This practice came back to bite the human race in the butt later, when [[TheChessmaster Crake]] takes it to the next level.
* In Creator/WilliamGibson's ''Literature/{{Neuromancer}}'', protagonist Henry Case betrayed a prior client and was punished with a toxin that crippled his ability to access cyberspace. His present employer heals the nerve damage as payment, then implants sacs of the same toxin as insurance.
* The villainous corporation in ''Confessions of Super-Mom'' makes both insulin and cereal, and deliberately uses the cereal to give children diabetes.
* In ''Literature/BestServedCold'' by Joe Abercrombie, master poisoner Castor Morveer and his apprentice Day use this a number of times. In some instances the trope is played straight, while in other cases there was actually no poison at all; in one of ''those'' cases, the proffered antidote is actually the real poison.
* [[EpicFail Fails epically]] in the first book of Creator/JohnRingo and Creator/DavidWeber's ''Literature/PrinceRoger'' series. Roger and his Marines are poisoned and ordered to fight for a tin-pot dictator with this gambit... which backfires amazingly because [[BizarreAlienBiology they're from a totally different planet]]. Even worse for the would-be poisoner, the poison used actually ''helps'' the humans, inspiring TheMedic to check another poison for providing a mineral necessary for biological functions but unable to be manufactured by their food replicators, and finding that it can help stretch out the suplements required by the civilian team lacking the nannites doing the conversions.
* Creator/BarbaraHambly's novel ''Literature/TheLadiesOfMandrigyn'' pulls a particularly delicious version of this gambit: at the beginning of the book, a poisoner slips Sun Wolf a particularly dreadful poison and daily casts spells keeping it from affecting him, but will not remove it from his system until he's completed a task. Much later, [[spoiler:he decides dying horribly is better than the alternatives, and escapes to crawl off and suffer the effects of the poison... which turn out to be the lost shamanic initiation everyone's been searching for the whole book. It's just better known as a poison, because it IS torturous and only a few are equipped to survive it.]]
* In the ''Literature/{{Lionboy}}'' books, [[spoiler:the Corporation]] induced an asthma epidemic in the general population in order to sell inhalers.
* ''Literature/ArtemisFowl'' once tricked a sprite into drinking a bottle of Holy Water, then offered her a shot of magical springwater that would counteract the Holy Water's effects in exchange for the opportunity to study The Book (the fairy equivalent of the bible).
* In the ''TabletopGame/MagicTheGathering'' novel ''Literature/AgentsOfArtifice'', Gemreth's demon injects Jace with a painful venom before it interrogates him, promising the antidote if he passes the test.
* Seen a few times in ''Literature/PerryRhodan'', typically as a longer-term blackmail plot: apply a relatively subtle, slow-acting but deadly futuristic poison to the victim (or, [[KickTheDog for extra dog-kicking points]], to somebody ''else'' the victim cares about), then regularly supply them with just enough counteragent to keep the poison in check but not actually neutralize it for good. The method has been used by planetary dictators, intelligence agencies of the more unscrupulous persuasion, and at least one starship captain using it to blackmail her own (admittedly likewise shady) ''crew''; naturally, employing it is a pretty good sign of the perpetrator having crossed the {{moral event horizon}} some time ago.
* Seen in ''Literature/{{Dune}}'' in a unique variant, directed at one person. When Thufir Hawat is captured by the Harkonnens, they administer a "latent" poison to him that will remain in the body but can be temporarily neutralized by frequent ingestion of an antidote. The technological poison sniffers won't register the antidote, which is harmless, and the poison within his body can't be detected. If the antidote is withdrawn, the poison will activate.
* In ''Literature/{{Jhereg}}'', Vlad and Kragar uncover an episode of this in the history of their target, Mellar: he won a noble's favor and aid by getting said noble in touch with a witch that could cure a plague. Mellar had hired the same witch to ''spread'' that plague to create that opportunity in the first place.
* In ''[[Literature/IxiaAndSitia Poison Study]]'', this is how the commander's food taster is kept loyal, with a dose of the cure needed every day. To make it harder for the subject to obtain another supply of the cure, [[spoiler: the poison does not exist. The "cure" is an addictive drug with painful withdrawal symptoms.]]
* In ''[[Literature/OldMansWar The Ghost Brigades]]'' the CDF induces an organ failure in a captured alien scientist that will kill him after several hours of painful seizures unless they give him an "antidote" that will stabilize his lymph analogs, temporarily. He talks.
* ''Literature/AScannerDarkly'': [[spoiler: New Path]] is behind Substance D, while providing rehabilitation for its addicted users, which also includes doing farm work-growing more of the drug.

[[folder:Live-Action TV]]
* River Song pulls one of these in the ''Series/DoctorWho'' episode "[[Recap/DoctorWhoS31E12ThePandoricaOpens The Pandorica Opens]]", while negotiating the sale of a [[TimeMachine Vortex Manipulator]] with a black market salesman in a bar.
--> '''River''': This device can disarm micro-explosives from up to 40 feet.
--> '''Trader''': Interesting, what kind of explosives? *Takes a sip of wine*
--> '''River''': The kind I just put in your wine.
* ''Series/GameOfThrones'': Tyene Sand insists that Bronn call her the most beautiful woman he's ever seen before giving him the antidote.
* VillainOfTheWeek Kivas Fajo pulls this in the ''Series/StarTrekTheNextGeneration'' episode "The Most Toys" when he poisons the water supply of a Federation colony so he can then sell the cure to the ''Enterprise''. However, his real goal is to get his hands on Data so that he can add a Soong-type android to his collection of rare things. One of the things that tips off the ''Enterprise'' crew that Kivas was up to something is when they find out he happened to be transporting ''exactly'' as much of the (very rare) cure as was needed to restore the water supply, no more and no less.
* The Doctor does this to a corrupt and compassionless {{Jerkass}} hospital administrator on an episode of ''Series/StarTrekVoyager''.
* Elizabeth does this to get Jim out of prison in the season finale of Series/TerraNova. [[spoiler: She was bluffing. The "cure" she injected was a sedative.]]
* In ''Series/BabylonFive'', Edgars Industries creates a virus that kills only telepaths, but also make a cure. They intend to turn some into slaves and kill the rest. [=PsiCorps=] itself finds out about this and takes messy revenge. (They keep the cure.)
** In another episode, a dual-latent-poison version (similar to the ''Dune'' example above) is used. When Lord Refa visits Londo on Babylon 5, Londo has a drink waiting for him. Londo asks Refa to end his association with [[spoiler:Mr Morden and the Shadows]], and when Refa asks why he would do that, Londo famously replies:
--->'''Londo''': Because I have asked you; because your sense of duty to our people should override any personal ambition; and because I have poisoned your drink.
*** Then, Londo explains to Refa that the poison won't kill him right away, but rather would fester in his body and not do anything, but turn deadly when it met a second poison, which is also harmless on its own, and which Londo also had and was capable of administering (remember, having a taster won't help, since the taster won't be susceptible to the second poison). Refa complies. For a while.
* ''Series/TheAmericans'': Philip and Elisabeth poison the son of the Secretary of Defense's maid in order to get her to steal a clock and then return it after they've planted a bug on it.
* A variation in ''Series/{{Merlin}}'' in that it's the ''hero'' who pulls it off, using a villain's ploy against them. On realizing that Morgana is the source of the spell that renders all of Camelot under an enchanted sleep, Merlin tricks her into drinking water spiked with hemlock. As she lays dying Morgause (who cast the spell in the first place) bursts in and Merlin breaks a deal with her: he'll give her the name of the poison if she lifts the spell over Camelot. She agrees in order to save Morgana's life (though if she hadn't, the spell would have been broken anyway with Morgana's death).
* ''Series/AlmostHuman'' has one episode involving an organ-trafficking scheme in which people desperately in need of new hearts are fitted with bio-mechanical hearts that are set to fail after thirty days. The timer can be reset, of course, for a very exorbitant fee.
* Gogol's introductory episode in ''Series/{{Nikita}}'' had the Russian paramilitary group capture Nikita and inject her with a Division-developed poison, with the antidote to be administered after she completed an assassination for them. [[spoiler:Alex manages to smuggle the antidote out of Division for Nikita, who then ensures the assassination fails.]]
* ''Series/BlakesSeven''.
** In "Traitor", the protagonists encounter Forbus, a ReluctantMadScientist who's been refining a brainwashing drug. Turns out [[BigBad Servalan]] infected him with a disease that causes an agonising death. After making him a cripple, she doles out an antidote that keeps the infection at bay, as long as he continues his work. Forbus constructs a homemade bomb to [[TakingYouWithMe kill them both]], but unfortunately Servalan shoots him first.
** In "Cygnus Alpha", a ScamReligion has been created around this trope, as the high priest has the only stocks of a medicine that must be administered for the rest of your life to fight off a local disease. Later he reveals that the disease is harmless and burns itself out in a few days.
* In the fifth season of ''Series/{{Arrow}}'', one of Oliver's off-screen victims as "The Hood" was Justin Claybourne, a man who first got involved with a black market group to spread weaponized polio in one of the poorer areas of Starling City, then bought up exclusive rights to a new polio cure and offered to sell it at exorbitant prices.

[[folder: Stand-Up Comedy]]
* One of Creator/{{Chris Rock}}'s bits on "Bigger And Blacker" accuses essentially the entirety of Western medicine of this, citing the fact that few diseases have been fully cured (as opposed to "patching it up" so that you can live long enough for them to "get more of your money") in recent years. One hopes that the InsaneTrollLogic involved is merely RuleOfFunny and that Mr. Rock is aware of the real reason (that the easy-to-cure diseases have already been cured, and what remains is more challenging). After all, if his reasoning was correct, [[IgnoredEpiphany "they" would never have invented or implemented the polio vaccine in the first place]].

[[folder: Tabletop Games]]
* In ''TabletopGame/{{Warhammer}}'' and ''TabletopGame/{{Warhammer 40000}}'', many turn to the Chaos God Nurgle to escape the effects of a crippling or deadly plague, only to discover Nurgle created it in the first place. The [[TabletopGame/BlackCrusade Tome of Decay]] says Nurgle cultists end up ''happy'' of learning that, because it means Nurgle took active steps to recruit them, meaning he has "chosen" them.

[[folder: Urban Legend]]
* [Insert disease here] is occasionally accused of having been intentionally created and introduced into the populace in various {{Urban Legend}}s and UsefulNotes/ConspiracyTheories.

* Used on a global scale in ''VideoGame/DeusEx'', with the synthetic disease "The Gray Death" (and very expensive vaccine "Ambrosia").
* The original ''VideoGame/BaldursGate'' had a side-quest where you were poisoned by an assassin, so you'd die in 10 days if his partner in crime weren't ready to help you... for a price [[spoiler:of removing the geas his "partner" put on him to make him cooperate]].
* Eidolons of ''VideoGame/FinalFantasyXIII'' start out by casting Doom on your party leader, leaving you with a time limit to defeat them. If you beat them, though, you get a fancy new summon!
* SelfDemonstrating/TheJoker does this in ''VideoGame/BatmanArkhamCity'', poisoning Franchise/{{Batman}} with the same disease that's slowly killing him and making the Dark Knight find a cure. Batman merely responds that he's fine with both of them dying, but the Joker anticipated that and managed to poison people all over Gotham with it, so now Batman ''really'' has to find a cure. Ultimately, [[spoiler:Batman cures himself, WordOfGod is that he manages to save Gotham, but the Joker's actions lead to him not getting the cure and so he dies.]]
* In the real-time tactics game ''Soldiers of Anarchy'', TheEndOfTheWorldAsWeKnowIt was caused by a virus that caused uncontrollable cellular mutations quickly followed by death. During the game, the COTUC route has the player's squad finding out that [[spoiler:the epidemic was caused by NOAH's predecessor, a medical firm who engineered the virus in order to get rich on the vaccine... [[SubvertedTrope only for the cure to prove ineffective]]]], while the NOAH route implies [[spoiler:COTUC somehow had a working cure all along, probably [[NoPlansNoPrototypeNoBackup having stolen it out of NOAH's labs after sabotaging the original research]] [[WithholdingTheCure to make their own survival appear miraculous to the common folk]]]]. Now, [[spoiler:NOAH]] are getting close to synthesizing the cure once more and are actively [[TheAtoner trying to restore the world as atonement]] while [[spoiler:COTUC]] are not only experimenting with the virus to make it even deadlier but intend to eliminate [[spoiler:NOAH]] as well to secure their position as the last major power in the world - ''fully intending to release the improved virus if they think they're losing.''[[note]][[GodzillaThreshold Which they attempt to do]] if the player attacks their headquarters.[[/note]] [[BlackAndGrayMorality Hoooly shit!]]
* ''VisualNovel/YoJinBo'' employs this trope, albeit mostly offscreen: in Bo and Ittosai's paths, the ninja Kasumimaru reveals that he persuaded [[spoiler:Ittosai]] to turn [[TheMole mole]] by [[spoiler:managing to cut him with a poisoned knife during battle, and then promising him money and the antidote in return for his help against the heroes]]. Interestingly, Kasumimaru apparently handed over the antidote as soon as the agreement was made, since it's never an issue [[spoiler:even when Ittosai inevitably reneges on the deal]].
* As the plot of the GameMod ''[[VideoGame/{{Marathon}} Marathon Rubicon]]'' unfolds, [[spoiler:the player can learn that this is ThePlan of Dangi Corporation. Which of the game's endings you get hinges on whether the player does anything to stop it. Naturally, the ending where the player does nothing to stop it is ''not pleasant''.]]
* ''VideoGame/{{Touhou}}'' has a non-poison version. Mystia Lorelei uses her blindness-inducing MagicMusic to sell grilled lamprey to humans as a blindness cure, with the intent of getting them so used to fish [[CarnivoreConfusion they stop eating poultry]] (she's a bird youkai).
* The title character in ''Nick Chase and the Deadly Diamond'' was forced to steal the stone in order to receive the antidote to the toxin "Mr. X" had poisoned him with.
* It's strongly implied that Agahnim[[note]]Who was possibly (part of) Ganon in disguise; it's not clear[[/note]] did this (releasing a plague into Hyrule, then arriving incognito as a sorcerer able to halt the plague) in the lead-up to ''VideoGame/TheLegendOfZeldaALinkToThePast''.
* In VideoGame/MegaMan10, Dr. Wily secretly spreads the Roboenza virus to afflict robots and leave humans helpless, then reveals that he caused it and says that anyone who wants to cure their robots should come work for him.
* Played with in the ''VideoGame/DeadRising'' franchise, as the company which holds the zombie plague medicine Zombrex has to intentionally start outbreaks in order to create the medicine. The price for Zombrex is high due to the company's high research costs, but gets extortionate for people in an outbreak due to the normal issues of supply and demand. They also claim to be researching a permanent cure for the zombie virus, and so far managed to make Zombrex last for 24 hours as opposed to twelve.
* In [[spoiler:the third time loop of]] ''VideoGame/BravelyDefault'', [=DeRosa=], Profiteur, and Dr. Qada plan to do this, but are stopped by your party before they can get started. Qada, who created both the poison and the cure, has a hard time deciding whether he wants his name to go down in history as the great hero that created the cure, [[EvilIsCool or the diabolical villain that created the]] ''[[EvilIsCool poison]]''.
* ''VideoGame/PresentableLiberty'' has this as part of the backstory, but with a twist: The cure ends up causing organ failure. [[BigBad Dr. Money]] tries capitalizing on this too by selling new organs, but they tend to fail very rapidly[[labelnote:*]] The Money box in the prequel game ''VideoGame/ExoptableMoney'' can generate organs late into the game. Presumably this is where these bad organs are coming from[[/labelnote]]. [[spoiler: Turns out, a legitimate cure does exist, and you were injected with it so your organs would become incredibly valuable.]]
* What kicks off the plot of ''VideoGame/JakXCombatRacing''. During the reading of Krew's last will, Krew reveals in a recording that he always wanted to win the Combat Racing Championship and demands that everyone present drive for him, revealing that the wine they toasted with was poisoned with minute doses of a slow acting poison known as Black Shade. Krew gives them an ultimatum: win the next Kras City Championship as his team and receive the antidote when they win, or die.

* In ''Webcomic/EightBitTheater'' a witch poisoned the "Light Warriors" to coerce them into retrieving her magic eye for her. However, because she was blind she didn't realize which poison she'd given them, and it turned out to be the one that causes sanity-straining nightmares.
* In ''Webcomic/DrowTales'', this forms two key elements of [[BigBad Snadhya'rune]]'s strategy to get elected Empress and force her own "[[{{Narcissist}} enlightened]]" views down everyone's throats.
** Snadhya'rune runs a nether cult that is obsessed with the idea of tainting, which basically involves infecting a [[OurFairiesAreDifferent Fae]]'s soul with a demon, and as such has been spreading the taint far and wide. Getting tainted generally means being consumed by the demon, but Snadhya'rune [[spoiler:has learned how to master control over it via SplitPersonalityMerge]] and is promoting it as a form of "enlightenment". At least two people of the people Snadhya'rune has "enlightened" completely switch loyalties, leading some to fear that Snadhya'rune is utilizing it as a means of brainwashing.
** She threatens to annihilate all of the clans with [[spoiler:a deadly infectious flower. Only those who bend to her rule will be given the cure]]. Surprisingly enough, a [[VillainWithGoodPublicity significant portion of the population]] strongly supports her goals. She has her first VillainousBreakdown in the entire strip when [[spoiler:Sarghress assassins kill the scientist responsible for the "Cure" part of the gambit. Making sure another scientist can make the cure becomes a very high priority for her. Unfortunately, said scientist left NoPlansNoPrototypeNoBackup due to a desire to keep her work a secret. As a result, Snadhya's flower plague quickly spreads beyond the control of everyone, including her]].
* Given a MadScientist twist in ''Webcomic/GirlGenius'' when it turns out the poisoner is also the cure - as long as he's alive and close by there is nothing to fear from the poison.
** Of course, he failed to properly take into account that the one poisoned was ''also'' a MadScientist. [[spoiler: She couldn't ''cure'' herself, but she could make another creature have the same preserving effect as the poisoner]].
* In ''{{Webcomic/Garanos}}'' the BigBad Gharsena [[spoiler:is the one who made the disease Gailen is dying from, a fact she uses to force Gailen to be her mole. When Gailen figures it out she attempts to kill her, but Gharsena just magically accelerates the disease until it kills her.]]
* One strip of ''Webcomic/{{Precocious}}'' shows Bud selling his famous "Muffins of Doom" from a booth, then his customer sees something else, panics and drops the muffin he was eating, and Autumn is shown in a booth selling "Antidotes".

* ''WesternAnimation/BatmanTheAnimatedSeries''
** In one episode, the Scarecrow releases a chemical which takes away all sensation of fear, making people dangerously reckless, with the plan of selling his fear toxin as the "antidote".
** And in an earlier one, CorruptCorporateExecutive Roland Daggett has stray animals infected with an incredibly virulent new strain of rabies that he plans to sell the cure for.
* In ''WesternAnimation/JackieChanAdventures'', Valmont infects Jackie with a poison that will [[TakenForGranite turn him into stone]], offering the antidote in exchange for all of the talismans that Jackie had collected thus far. Jade then [[CrowningMomentOfAwesome breaks into what amounts to a FBI headquarters]] in order to save her uncle. Of course, Jade missed one and Tohru responded by smashing the antidote. [[GoodThingYouCanHeal Good thing the Horse Talisman grants you healing powers]]...
* One episode of ''WesternAnimation/{{Gargoyles}}'' double subverts this. Demona tries to pull a deal of this kind by shooting Elisa with a poisoned dart and coercing the gargoyles to help her in return for the antidote. Unbeknownst to her [[PocketProtector Elisa's badge deflected the dart]]. The Gargoyles spring the trap anyway, out of curiosity, and so Demona will think she succeeded.
** An extra twist comes up in the end, [[ILied when Demona gloats that there]] ''[[ILied is]]'' [[ILied no antidote]] right before she gets away. It was a XanatosGambit that would result in the deaths of at least one of her foes and possibly more as a fringe benefit. Thank God for that badge...
* This launches the main plot in the OneEpisodeWonder ''WesternAnimation/KorgothOfBarbaria''. A FauxAffablyEvil thief invites BarbarianHero Korgoth to dinner while he talks about hiring Korgoth for a job. When Korgoth refuses to take the job after dinner, the thief reveals that there was a deadly parasite in Korgoth's food, and the only way he'll give Korgoth the elixir to cure it is if Korgoth does the job.
* In ''WesternAnimation/AdventureTime'' episode "Jake vs. Me-mow", Me-mow uses this to blackmail Jake into assassinating the Wildberry Princess. It doesn't take, however, when Me-mow [[ExplainingYourPowerToTheEnemy reveals that the toxin is enough to kill 50 dogs,]] leading [[{{Sizeshifter}} Jake]] to realize [[TakeAThirdOption he can just supersize his liver by 51]] and absorb said toxin.
* In the ''WesternAnimation/DrawnTogether'' episode "The Other Cousin", Clara poisons Hero and promises to give him the antidote if he shows her cousin Bleh a good time. This becomes a WhatHappenedToTheMouse moment in the broadcast version when he's not seen getting the antidote in the episode (the extended DVD version does in fact show Clara giving it to him).
* ''WesternAnimation/DannyPhantom'': In the episode "Masters of All Time," [[BigBad Vlad]], suffering from another outbreak of the Ecto-Acne disease, approaches Danny for help in curing it, and infects Sam and Tucker with the disease as well to ensure Danny's cooperation.

* There was a thought experiment that played with this trope. The premise was that your best friend is dying of a unique disease, and the only cure is held by a doctor who wants more money for it than you can get. It's supposed to provoke questions of what [[ShadesOfConflict morality]] truly means.
* The S'Hamala or Chumash of California had antap, or medicine men/women, who poisoned enemies and then blackmailed them.