-> ''"I plan to live forever of course, but barring that, I'd settle for a couple thousand years. Even five hundred would be pretty nice."''
-->-- '''CEO Nwabudike Morgan - [=MorganLink=] [=3DVision=] Interview''', ''VideoGame/SidMeiersAlphaCentauri''

In many science-fiction works, both CyberPunk and SpaceOpera, it's not uncommon for humans, or at least the upper classes, to [[LongLived live for centuries]]. Most often the reason for this is some form of technology ranging from alien substances to gene therapy to nanomachines.

A subtrope of ImmortalityInducer, usually results in LongLived or TheAgeless. BrainUploading counts when the brain is downloaded into a clone or other biological body, but not if into a machine.

* The Lazarus Pits used by ComicBook/RasAlGhul rejuvenate him every century or so.

* In ''Film/InTime'', the aging gene has been "shut down", freezing aging at 25. But to prevent overpopulation and present an anvilicious message about income disparity, people are programmed to die at a certain time and use their remaining time as currency.
* In ''Film/{{Tomorrowland}}'' Governor Nix looks exactly the same in 2015 as he did in 1964. Apparently thanks to some kind of shake he drinks every morning.
* In ''Film/JupiterAscending'' "Recode" rejuvenates people when they bathe in it. Kalique Abrasax is 14,004 years old and her mother was starting her 91st millenium when she was murdered. [[spoiler: And it's made from human cells, harvested a planet at a time.]]

* Rejuv in the ''Literature/AllianceUnion'' universe is made from a lifeform native to Cyteen and delays aging up to a century. Side effects include sterility and loss of hair color.
* The spice melange in ''Franchise/{{Dune}}'' can extend lifespans up to 300 years.
** The [[Literature/LegendsOfDune prequels]] reveal that the Old Empire had a treatment that could extend lifespans even longer, and without causing a drug dependency. When one of the characters receives it (allowing him to stick around for the next few books), it's mentioned to be extremely painful.
* The ''Literature/RedMarsTrilogy'' features a specialized gene therapy referred to as a "gerontological treatment". The books span over two hundred years and most the major characters, many of whom were ''already'' in their 40s and 50s at the start of the series, are alive and active that entire time due to repeated use of the treatment.
* In Creator/RobertAHeinlein's future history series, particularly ''Literature/MethuselahsChildren'' and ''Literature/TimeEnoughForLove'', humanity develops a form of rejuvenation through blood replacement after a group of naturally long-lived people reveal themselves and then hijack a starship when the rest of the species demand they reveal their "secret". Later more advanced methods including complete body replacement are developed.
* In the ''Literature/TakeshiKovacs'' series, people are implanted with "cortical stacks" at birth that record one's brain state so that when they die, they can be "resleeved" in a new body.
* In Norman Spinrad's ''Literature/BugJackBarron'', an investigative reporter and consumer advocate begins investigating an organization that provides rejuvenation treatments to the rich and powerful, and finds far more than he bargained for.
* Creator/RogerZelazny:
** In ''Literature/LordOfLight'', the so-called "Gods" (actually mutant humans) have mind-transfer technology that they use to reward or punish people. Be good, and you may end up with a bright, shiny new young body. Be bad, and you may end up with the old, worn-out body left by someone who was good.
** In ''Literature/CreaturesOfLightAndDarkness'', the technologically advanced world of Blis has more-or-less eliminated death by old age. Death is so rare that the few who volunteer for suicide can leave their heirs a legacy by selling tickets to watch the death.
* In Creator/JohnScalzi's ''Literature/OldMansWar'', rejuvenation treatment via consciousness transfer to a genetically enhanced body is only available to military personnel--and the minimum age for joining the military is 75.
* In Wil [=McCarthy=]'s ''The Queendom of Sol'' series, you can "print" a new body for yourself, and then have your mind transferred into it. In the golden years of the queendom, everyone travels ''everywhere'' by fax, and so has their body reset to a healthy 25 on pretty much a daily basis.
* From Creator/LarryNiven's ''Literature/KnownSpace'' stories:
** Boosterspice (a drug derived from genetically engineered ragweed) can tremendously extend the human lifespan.
** ''Literature/{{Ringworld}}''. There is an equivalent to boosterspice available on the title space construct.
** ''A World Out of Time'' has an immortality treatment for adults that involves removing impurities from the body.
* The prolong treatments in the ''Literature/HonorHarrington'' books. Its most blatant example is Honor's mother, Allison, who at 90 is still very attractive and capable of bearing children. And since Honor received a more advanced version of the treatment, she's likely to live even longer. Also, people not only look very young for decades, they also have the hormonal levels corresponding with the apparent age ''for decades''. In the latter books, prolong becomes a key indicator of how socially and economically evolved a planet is: if you look old, it likely means you're poor. When the [[spoiler:Star Empire of Manticore]] is created, receiving prolong is made a fundamental, inalienable right of every citizen.
* Citizens of Literature/TheCulture are genetically engineered to live for centuries, longer if they feel like it.
* In John Norman's ''Literature/{{Gor}}'' novels, the Caste of Physicians developed a treatment called the Stabilization Serums, which allowed the recipient to live for hundreds of years [[note]]in 'Marauders of Gor', Tarl meets someone who is almost certainly the legendary founder of Torvaldsland, which would make him about 1000 years old[[/note]]. The Priest-Kings, the PhysicalGods of the setting, have a similar treatment, the oldest being about 5,000,000 years old.
* In ''Turnabout'' by Margaret Peterson Haddix, the government is working on a top-secret experiment in 2000 to reverse the aging process. And it works - the main characters, who were extremely elderly and would have died before long, are given the chance to grow young again. Unfortunately, they haven't figured out a working way to ''stop'' the un-aging.
* In Creator/VernorVinge's ''Literature/RainbowsEnd'': the Venn-Kurasawa treatments. They only work for one in a thousand, but for those they do work for, they can restore the appearance of youth, and add many years of actual lifespan. Robert Gu is one of the lucky few who respond to the treatments.
* Poulsen treatments in the ''{{Literature/Hyperion}}'' series. It will extend one's life to a few centuries - one person lived close to a thousand, although it also included a lot of time as a HumanPopsicle. However, after a few times, the skin starts literally glowing blue, and it is of limited use on old people. [[ArtificialHuman Androids]] are built with the process being constant in their bodies, and can live for six or more centuries without visible signs of aging.
* The same name was later used in Creator/RobertReed's novel, ''The Remarkables''. It can greatly expand one's life (beyond the already genetically enhanced ~150 year lifespan), though the treatment leaves visible marks - one of the characters who has had extensive treatments has an almost young face, but wrinkled hands and oddly colored skin.
* In the ''Literature/ChildrenOfSteel'' series it's mentioned that humans can take life extension treatments that make the age of some of the executives hard to discern. There's no indication whether it's possible to use those on animorphs.
* In Creator/MikhailAkhmanov and Christopher Nicholas Gilmore's ''Literature/CaptainFrenchOrTheQuestForParadise'', the Cellular Regeneration treatment available on most worlds has, effectively, turned humanity into TheAgeless. People choose when to "freeze" their age with most picking sometime in their 20s, although some wait until 30 in order to look "more mature". The only people who die of old age are either criminals on worlds where capital crime is punished by aging (reversing the treatment) and on recently-settled worlds where CR machines have not yet been set up. It's mentioned by the titular protagonist that, even before CR, various treatments (including cloned organs and blood vessel cleansing) have extended expected lifespans to centuries.
* The Betans of the ''Literature/VorkosiganSaga'' allegedly have one, which people assume is the reason that Admiral Naismith commands a mercenary fleet while appearing to be in his early twenties. In truth, there is no such treatment, and Admiral Naismith really is in his early twenties. The Jacksonians have a highly unethical treatment in which the brain of a wealthy client is transferred into the body of a younger clone. Mark Vorkosigan has made it his life's work to eliminate that practice, and as of the chronologically latest book was about to begin testing of a treatment that could potentially revert someone from 'old' to 'middle aged'.

[[AC: Live Action TV]]
* ''Series/StargateSG1'', several examples, all with severe side effects:
** The sarcophagus can extend the life of a human without a [[PuppeteerParasite Goa'uld]] for 700 years or so, hosts for millennia. Unfortunately it makes the user megalomaniacal. [[ImmortalityImmorality Because reasons.]]
*** A later episode eventually reveals that even a sarcophagus has its limits for a Goa'uld symbiote. Lord Yu is, apparently, one of the oldest symbiotes in existence. He spends most of his time in a sarcophagus, but still has fits of senility (such as ordering his fleet to a system half a galaxy away in order to fight a battle that was already fought years ago). His First Prime knows all this and covers it up, loyally following his master's orders even if they are the result of his senility.
** In the episode ''2010'' the Aschen give earth a life-extension drug that serves to explain why SG-1 hadn't aged at all in ten years. It also turned out to cause sterility, as part of an Aschen plot to depopulate earth so they could turn it into an agricultural colony. Necessitating TimeTravel to prevent the earth-Aschen alliance.

[[AC:Tabletop Games]]
* In ''TabletopGame/ArsMagica'', Hermetic Magi are able to create a longevity ritual that can drastically slow the aging process. The ''Mysteries'' sourcebook provides a significantly more powerful version in the form of an alchemical Elixir of Life.
* Anagathic drugs in ''TabletopGame/{{Traveller}}'', frequently banned or controlled. Require monthly doses or the character is forced to make an aging roll.
* A couple of nanosymbionts in ''GURPS TabletopGame/TranshumanSpace'' extend life expectancy by 10 years and expensive "rejuvenation" treatments can actually reverse the aging process.
* The space marines' biological enhancements in ''TabletopGame/{{Warhammer 40000}}'' setting allow them to live a millennium or more. Unenhanced human nobles and dignitaries have "rejuvenat" or simply "juveant" treatments, enabling them to live several centuries longer than ordinary humans. Some sources imply that certain variants of these procedures use raw materials [[PoweredByAForsakenChild From Living Children.]]
* The CCG ''TabletopGame/{{Illuminati}}'' has the [[http://media.adamdodson.org/index.php/Illuminati-Card-Game/immortality-serum "immortality serum" card]] that makes a personality indestructible and can also cause an opponent's personality to defect.
* ''TabletopGame/EclipsePhase'' mentions longevity treatments as part of the backstory. Though they're apparently obsolete now (outside the Junta) since longevity is included in most Basic Biomods and BrainUploading is commonplace.
* ''TabletopGame/{{Shadowrun}}'' features a number of age rejuvenation treatments. Leonization, the most expensive, restores physical age to approximately 21, a life span extension is a one-time procedure that adds 10 years to your life, while physical vigor simply counters the physical side effects of aging.
* Longevity treatments exist in the ''MutantChronicles'' setting, but between the astronomic expense, the invasive surgery and the extremely strict regimen of diet and exercise required for the treatment to be effective, very few people bother.

[[AC:Video Games]]
* ''VideoGame/TheSims 2'' features a carnivorous plant (the cowplant) that produces a substance that, when drunk, gives a Sim an extra day of life.
** ''VideoGame/TheSims3'' has a plant called '''life fruit''', which expand at least one day of a sim's life. Said fruit is a critical ingredient in the Ambrosia recipe that resets a Sim to the start of their current life stage.
* In the ''Franchise/MassEffect'' series, humans commonly live to 150 or so due to gene therapies and drugs. This puts us in the mid-range for lifespans in that universe.
* Several forms appear in ''Videogame/SidMeiersAlphaCentauri'':
** There is a secret project called 'The Longevity Vaccine' and another called 'Clinical Immortality'.
** It is mentioned that the player character goes through some sort of gene therapy on a regular basis to explain how he stays alive for the full five centuries of the game.
** One of the other characters is said to have kept a strict 'longevity regimen'.
* In ''VideoGame/SwordOfTheStars II'' anagathics technologies extend the lifespans of your admirals.

* A plot point in ''Webcomic/SchlockMercenary'' is "Project Laz'r'us", which was intended to circumvent humanity's [[WeAreAsMayflies short lifespans]] in comparison to many other sophonts using hyper-advanced nanotechnology. The nannies are also capable of repairing a clinically dead host and even making internal backups of the brain. The species from whose computer equipment carbosilicate amorphs has evolved already made themselves immortal and ran into several layers of problems. Still, there's a few remaining individuals alive and sane after their twelve million Terran years, "[[http://www.schlockmercenary.com/2007-07-14 give or take a little bit]]".
* In the future of ''Webcomic/{{SSDD}}'', the wealthy are able to afford implants that extend lifespans until an accident kills them. At least two of [[MegaCorp Maytec's]] board of directors are in their fifties and appear to be twenty.
* In ''Webcomic/{{Freefall}}'', life extension drugs are apparently available over the counter. At one point, Florence (an [[UpliftedAnimal uplifted]] red wolf) states that her projected lifespan of 160 years is slightly shorter than that of a human.
* In ''Webcomic/EscapeFromTerra'', rejuvenation treatments are one of many examples of bio- and nanotechnology that are officially banned on Earth. Reggie King and Babbette the elder undergo the treatment on Mars, and the first man on Mars is a great-great-great-grandfather who looks no older than 30.
* In ''Webcomic/QuantumVibe'', rejuvenation treatments are even more readily available. One of the main characters is reportedly in his third century, but there's evidence that he's ''[[ReallySevenHundredYearsOld over 500 years old.]]''
* ''Webcomic/TheDragonDoctors'': The effects of a FountainOfYouth were reverse-engineered about a century earlier. The Fountain itself is a deadly lake that regresses everything to nothing within its radius, but learning its magic has allowed other characters to get regular rejuvenation treatments. In Mori's backstory it is shown that she helped discover it and was rather old before someone tried to kill her by dunking her head in the lake, she went from about 60 to 20, she also adopted the sole survivor of the previous team to the area who had been regressed to a baby.
* In ''Webcomic/GenocideMan'' the titular Genocide Men had a variety of procedures done that allowed them to continue operating well into their 90s or 100s, Jacob Doe is 98. Artificial glands to stabilize hormones, nanotube-laced skeletons to prevent broken bones, and telomerase to prevent cancer. The former two sets of augmentations have [[SuperSoldier other bonuses]] as well.

[[AC: Web Original]]
* In ''WebOriginal/OrionsArm'' most [[HumanSubspecies nearbaselines]] are genetically engineered to live about 500 years. But due to medical nanotechnology and brain uploading most in the Sephirotic Empires live to 3,000 before succumbing to ennui or [[AscendToAHigherPlaneOfExistence transcending]].

[[AC: Western Animation]]
* In ''WesternAnimation/BatmanTheAnimatedSeries'' Poison Ivy under the guise of Dr. Demeter offers this treatment to rich industrialists but in reality is turning them into trees as karmic justice for their enviromental destruction. She has no qualms about going after their friends or loved ones as well.