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[[quoteright:350:[[VideoGame/TalesOfTheAbyss http://static.tvtropes.org/pmwiki/pub/images/LukeVsAsch_4787.jpg]]]]
[[caption-width-right:350:A man and his REPLICAAAAAAAA!]]

There are clues a creator can apply to a pair of characters to indicate that that they are opposites in some way. One of those is to give the characters opposite handedness, making them more than just metaphorically mirror images.

Expect to see tropes like EvilCounterpart, EvilKnockoff, CainAndAbel, PolarOppositeTwins, TheLancer, or TheRival and RivalTurnedEvil. Also expect to see a lot of parallels in their respective characters and stories - they are as much alike as they are opposites. Commonly, they will represent what the other could have become, had they made different choices or had slightly different luck.

Note that in RealLife, 20% of twins (including identical twins) have opposite handedness, which may be part of the origins of this trope.

Most often, the character with the left hand will be the [[ASinisterClue evil one]], or at least less of a hero than the right-handed character.

See TheSouthpaw for when being left-handed is advantageous. Often overlaps with ASinisterClue, in which left-handedness is visual shorthand for being evil.

Compare HairContrastDuo, where another physical characteristic is used to symbolize the contrast between characters.

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!!Examples:

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[[folder:Anime and Manga]]
* Fate Testarossa from ''Anime/MagicalGirlLyricalNanoha'' is this on two levels: firstly, she is a right-handed DarkMagicalGirl to the left-handed title character. Secondly, she is [[spoiler:an [[ReplacementGoldfish imperfect clone of her creator's late left-handed daughter]]; in fact, Fate's handedness was one of the things that made Presea realize that she is not Alicia and reject her]].
** Subaru Nakajima and her left-handed older sister, Ginga, have each one of the two [[PowerFist Revolver Knuckles]] from their late mother, Quint. Additionally, a Revolver Knuckle can change its color to fit the color scheme of the holder, resulting that Subaru's right Revolver Knuckle is black while Ginga's left Revolver Knuckle is white.
* ''Manga/RosarioToVampire'' has a variation in Hokuto Kaneshiro, acting as a sort of mirror to main character Tsukune Aono. Both are humans come to this school for monsters by sheer luck (or lack thereof; neither is really sure), both are given monster blood to survive, and both [[spoiler:end up with out-of-control monstrous powers]]. Tsukune Aono's monster blood is sealed by a Holy Lock on the wrist of his right hand, and he has an honest determination to make alliances between humans and monsters. Hokuto Kaneshiro's mosnter blood is sealed by a Holy Lock on the wrist of his left hand, and [[spoiler:he goes absolutely monstrel-shit crazy and tries to send monsters and humans into an utter and complete bloodfest]].
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[[folder:Literature]]
* Quite Literally in "Let's Get Invisible!" from ''{{Goosebumps}}''. Lefty's counterpart in the mirror world is right-handed and [[spoiler: he switches places permanently with Lefty]].
* ''Literature/TheReynardCycle'': Reynard and Isengrim's RedOniBlueOni relationship with each other evokes this trope in the names of their weapons: Isengrim's sword is called Right-Hand, while Reynard's BladeBelowTheShoulder is called Left-Hand.
* Arya and Sansa Stark of ''Literature/ASongOfIceAndFire''. TheSouthpaw Arya is a {{Tomboy}} and a {{Deconstruction}} of the RebelliousPrincess archetype, while her right-handed sister Sansa is the [[TomboyAndGirlyGirl girly-girl]] and a {{Deconstruction}} of PrincessClassic.
* In Creator/JamesBlish's ''Spock Must Die'', a duplicate of Spock is left-handed. He has to fake right-handedness to maintain his cover.
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[[folder:Live-Action TV]]
* Played with in ''Series/ThePrisoner'' TOS episode "The Schizoid Man". Number 2 creates an exact double of Number Six and uses him to confuse Number Six into thinking that he's the double. The Villagers use aversion therapy on Number Six to turn him from right-handed to left-handed. The double is right handed, which he uses to claim that he's the real Number Six.
* In ''Series/OrphanBlack'', Helena, the only left-handed clone, is a serial killer brainwashed into thinking she's the original. The "mirror" part comes into play when we learn that [[spoiler:she's Sarah's twin.]]
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[[folder:Music]]
* ''{{Vocaloid}}'' brings this out with Len and Rin Kagamine, opposite-gender mirrors of each other or HalfIdenticalTwins (depending on who you ask). Their genderswaps even look a lot similar to the twin. This trope is most evident in {{Fanon}} works involving these two, as their official characterizations are virtually nonexistent.
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[[folder:Myth, Legend, and Oral Tradition]]
* An Iroquois legend states that the world was created by a pair of twins. The right-handed twin made the landscapes, plants, and animals. The left-handed twin created snakes, thorns, and storms.
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[[folder:Video Games]]
* Luciana and Aegiana of ''VideoGame/YggdraUnion'' who, despite being identical twins, have opposite handedness. RedOniBlueOni is in full effect for these two.
* The ''Franchise/FinalFantasy'' series is quite fond of this trope:
** ''VideoGame/FinalFantasyII'': Leon, a guest member during the firsr unbeatable fight who later found to be brainwashed and working for TheEmpire as a dark knight, is left-handed, in contrary with his best friend Frion, The right-handed [[TheHero hero]] with a overall theme of being a warrior of light.
** ''VideoGame/FinalFantasyIV'':
*** Kain, who is in many ways a "what could have been" for right-handed hero Cecil. Both share a very similar backstory, and both vow to fight against Baron, but Kain ends up BrainwashedAndCrazy and fighting for Golbez, while Cecil narrowly avoids that fate and becomes a Paladin.
*** Cecil's unknown brother Golbez from the same game is left-handed, and only through luck did Cecil not end up in Golbez's villainous role.
*** Twins Palom and Porom, who are PolarOppositeTwins in both personality and powers, with one being a BlackMagicianBoy and the other being a WhiteMagicianGirl. Palom is the left-handed twin, and far less nice than Porom, although he is by no means a villain.
** Similarly, in ''VideoGame/FinalFantasyVII'' and ''CrisisCore'', Sephiroth is left-handed while both Cloud and Zack are right-handed. They are in many, many ways warped mirror images of each other.
** In ''VideoGame/FinalFantasyDimensions'', Nacht and Sol are both orphans chosen by the Crystal. Right-handed Sol is the leader of the Warriors of the Light, and is an IdiotHero GenkiBoy, with blond hair, and a [[MeaningfulName name that means sun]]. Left-handed Nacht is the leader of the Warriors of the Dark (although DarkIsNotEvil in this game), and is TheStoic, with dark teal hair, and [[MeaningfulName a name that means night]].
* An interesting variation occurs in the ''Franchise/KingdomHearts'' series. Protagonists Terra and Riku have many, many parallels, including sharing the same role in a TwoGuysAndAGirl trio, complete with same ThemeNaming. They both are destined keyblade wielders, both are misled and manipulated by Maleficent and Xehanort, and both succumb to the Darkness in their hearts. But while Terra [[spoiler: is lost to his inner Darkness and becomes a Xehanort host]], Riku [[spoiler:conquers his inner Darkness and uses it to defend the Light, thus escaping Terra's fate]]. The variation occurs in that both characters are actually right-handed, but nearly all Terra's powers of Darkness manifest through his left hand, while Riku's manifest through his right.
* In ''VideoGame/TalesOfTheAbyss'', Asch wields his sword with his right arm and Luke wields his with his left. In a twist, however, Luke is the LeftHandedMirror to Asch rather than the other way around. In another twist, Asch is actually also left-handed - he just taught himself to fight right-handed to differentiate himself from Luke, [[BerserkButton whom he despises]].
** Similarly, in ''VideoGame/TalesOfVesperia'' Yuri wields left-handed by default (though he can and does occasionally switch to his right), while [[TheRival Flynn]] is right-handed. Fittingly, Yuri is much more of an AntiHero than Flynn is, and has a [[TheSouthpaw more creative combat style]]. ''Vesperia'' also gives us twin assassins Gauche and Droite, whose names literally mean 'left' and 'right' in French.
* Happens logically in ''VideoGame/{{Glover}}'', where the protagonist is an enchanted [[WhiteGloves magician's glove]]. The bad guy, naturally, is the other glove.
* A prime example is the original ''Franchise/TheLegendOfZelda'' games. A bit twisted around though because Link is the left-handed hero and Ganondorf is the right-handed villain.
* Siegfried Schtauffen and his SuperpoweredEvilSide, Nightmare, from the ''VideoGame/SoulSeries'' are ambidextrous. While Siegfried prefers to wield his sword in his right hand, Nightmare prefers to wield it in his left hand.
* [[Franchise/SonicTheHedgehog Shadow the Hedgehog]] is left handed in [[VideoGame/ShadowTheHedgehog his own game]], possibly to invoke this trope to oppose him to Sonic, who is right-handed.
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