- First Strike, a 1979 documentary by the United States Air Force later used as Stock Footage in The Day After.
- Police Story 4 First Strike, a 1996 Hong Kong martial arts/comedy film starring Jackie Chan.
- Halo: First Strike, a 2003 Halo novel set between Halo: Combat Evolved and Halo 2.
- First Strike, a Downloadable Content pack for Call of Duty: Black Ops released in 2011.
- The First Strike mod for Battlefield 2142.