"First Strike" might be any of the following pages:
* ''Film/FirstStrike'', a 1979 documentary by the United States Air Force later used as StockFootage in ''Film/TheDayAfter''.
* ''Film/PoliceStory4FirstStrike'', a 1996 Hong Kong martial arts/comedy film starring Creator/JackieChan.
* ''Literature/HaloFirstStrike'', a 2003 ''Franchise/{{Halo}}'' novel set between ''VideoGame/HaloCombatEvolved'' and ''VideoGame/{{Halo 2}}''.
* ''First Strike'', a DownloadableContent pack for VideoGame/CallOfDutyBlackOps released in 2011.
* The ''VideoGame/FirstStrike'' mod for ''VideoGame/Battlefield2142''.