Endgame may refer to:
- The 2011 Canadian crime drama Endgame.
- The post-apocalyptic LARP Endgame.
- The one-act Samuel Beckett play Endgame.
- The PlayStation 2 Light Gun game Endgame.
- The open-source Strategy Game Endgame: Singularity.
- The 2000 film Highlander: Endgame.
- The Nancy Garden Young Adult novel Endgame.
- A Stock Episode Title common to many series.
- The Star Trek: Voyager series finale, "Endgame".
- The ending scenario of a game, most commonly referring to chess.