History MadScientist / WesternAnimation

* ''WesternAnimation/TinyToonAdventures'' has Dr. [[PunnyName Gene Splicer]], the BigBad of the episode, "Hare Raising Night", who specializes in making MixAndMatchCritters, most notably Melvin the Monster. In addition, he is a boss in the UsefulNotes/SuperNintendo game, ''[[VideoGame/TinyToonAdventuresBusterBustsLoose Buster Busts Loose]]'', but in that game, he's only referred to as "the Mad Scientist". He is also the main villain (aside from Montana Max himself) in the UsefulNotes/SegaGenesis game, ''[[VideoGame/TinyToonAdventuresBustersHiddenTreasure Buster's Hidden Treasure]]'', which properly uses his full name.

* ''WesternAnimation/AdventureTime'': [[Characters/AdventureTimePrincessBubblegum Princess Bubblegum]] is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and peace-loving, she has accidentally unleashed a zombie plague twice, created a number of artificial life-forms (including all the citizens of the Candy Kingdom, a giant immortal candy sphinx named Goliad who almost destroyed the kingdom, and the tyrannical, emotionally-unstable Earl of Lemongrab), has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts imprisoned on spurious charges just because she was mad about him compulsively eating her pudding stash, and was prepared to torture the Ice King in order to get a cure for the outbreak of "freezer-burn flu" he accidentally unleashed. Her "For SCIENCE!" attitude, and her devotion to protecting her kingdom, cause... interesting things to happen. Assuming that he was the one who designed and built the [[ElectricTorture Reconditioning Chamber]] and the [[CoolSword Sound Sword]], then [[TheMentallyDisturbed Lemongrab]] definitely qualifies.

* Dr. Thadeus "Rusty" Venture in ''WesternAnimation/TheVentureBros'', although his lack of ambitions and laziness mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb (confirmed, as part of his backstory)

-->'''Prof. Farnsworth:''' You can't just waltz into the Central Bureaucracy! It's a tangled web of red tape and regulations. I've never been, but a friend of mine went completely mad trying to find the washroom there.\\

'''Prof. Farnsworth:''' Oh, I've been there. Lots of times! ''([[EvilLaugh Laughs maniacally]])''

-->"I think I can build something that can help us... '''or cause untold horrors'''! (EvilLaugh)"
* ''WesternAnimation/TheHead'': Not how the trope usually plays out, as he's a PunchClockVillain rather than a DiabolicalMastermind, but Dr. Elliot starts out as a CloudCuckoolander and [[SanitySlippage just gets worse from there]], to the point that his mooks eventually mutiny against him.

** VillainProtagonist Reagan Ridley is a GadgeteerGenius working as a team leader for an EvilInc run by TheIlluminati to help administrate their control over the free world. She's more on the AffablyEvil side of the spectrum, but her CloudCuckoolander tendencies and [[NoSocialSkills lack of social skills]] have resulted in a mountain of HR complaints about actions such as terrorizing her coworkers with a {{mecha}} for forgetting to fill out their time cards.

** Reagan's father Rand was her predecessor at the company but was fired after he had a mental breakdown that resulted in him attempting to [[TheNightThatNeverEnds destroy the Sun]] (which he justifies by saying he was going to end skin cancer) and almost blowing their cover. Nowadays he's TheAlcoholic CloudCuckoolander who spends his time finding [[TheGadfly creative ways to piss off his old boss]], such as turning Reagan's robotic replica of the President of the United States into a PresidentEvil or starting a Website/YouTube channel [[CassandraTruth exposing various conspiracies]] [[ConspiracyTheorist but acting crazy enough that nobody believes him so he's more of an inconvenience than an actual threat to the organization]].
* ''WesternAnimation/InspectorGadget'':
** One episode features the [[FunWithAcronyms M.A.D.]] Scientist -- that is, a scientist that works for M.A.D. However, he gets [[BerserkButton really, really peeved when someone calls him a mad scientist]], screaming, "I'M NOT MAD!"
--->"I'm not '''MAD!''' I'm '''Dr. Focus!'''" ''(gets arrested)'' "Now I'm '''really''' mad!"
** The 1999 feature film has Dr. Artemis Bradford and his daughter, Brenda, both of whom designed the title cyborg. The 2003 sequel has Baxter, who could ''possibly'' qualify...
* ''WesternAnimation/InvaderZim'': [[Characters/InvaderZimZim The title character]] is a mad scientist himself. In fact, in a script for an incomplete StartOfDarkness episode about him, Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.
** Dib and Professor Membrane would arguably qualify as Mad Scientists. Dib perhaps more so since his inventions revolve around his all-consuming obsession to destroy ZIM, whereas his father's inventions are more geared toward helping humanity. Even the Super Toast.
*** So they're ''good'' Mad Scientists?

* ''WesternAnimation/JonnyQuest'' TOS:
** Dr. Ashida in "Dragons of Ashida", who used genetic engineering on lizards to increase their size and also had a [[LaughingMad Maniacal Laugh]].
** In "Terror Island", Dr. Chu Sing Ling used a chemical to grow gigantic versions of normal creatures.
** Dr. Phorbus in "Peril of the Reptilian"
** Dr. Zin in general.
* The ''WesternAnimation/JusticeLeague'' cartoon version of Ultra-Humanite has all the characteristics of the traditional, cultured MadScientist. With an emphasis on 'cultured'.
--->'''Ultra-Humanite''' ''[[ItMakesSenseInContext (giving an educational toy to a group of orphans)]]'': [[PetTheDog "I welcome any opportunity to bring culture to the uncorrupted."]]
* ''WesternAnimation/{{Kaeloo}}'': Olaf, who is bent on trying to TakeOverTheWorld. He builds robots which he uses to attack people and doesn't think twice before kidnapping [[CosmicPlaything Stumpy]] and turning him into a cyborg [[UnwillingRoboticisation against his will.]]

* ''WesternAnimation/LeagueOfSuperEvil'''s Doktor Frogg.

*** With Phineastein, the Regurgitator, Professor Poofenplotz and all the members of L.O.V.E.M.U.F.F.I.N., it seems the show runs on this trope.

* [[NoNameGiven Whatever the scientist was]] who decided to resurrect a [[WesternAnimation/RobotChicken dead chicken in the title sequence for Seasons 1-5]].
** The character in question is named [[MeaningfulName Dr. Fritz Huhnmörder]], though it isn't mentioned much ([[AllThereInTheManual not at all]]).
* ''WesternAnimation/ScoobyDoo'':
** Velma Dinkley, the brains of the Scooby gang, becomes a mad scientist in the [=DVD=] feature ''Scooby-Doo: Frankencreepy,'' but only because she was hypnotized.
** In the classic episode "A Gaggle Of Galloping Ghosts," Shaggy and Scooby play "mad scientist," whipping up a formula that would turn werewolves into pussycats. It is summarily rejected.

-->'''Scooby:''' Rive my reation rife!!

-->'''Frink:''' ''(as a radio controlled baby-plane with his son in it crashes)'' Oh dear. My wife is going to kill me.
* ''WesternAnimation/SkysurferStrikeForce'' BigBad, Cybron who creates at least seven (maybe his own daughter too makes eight) lethal cyborgs, then wires an experimental computer brain into himself.

** Dr. Mephesto, based on [[Film/TheIslandOfDrMoreau1996 Marlon Brando's Dr. Moreau]]. The guy's greatest experiment is a FIVE ASSED MONKEY!

'''Mephesto:''' Sir, if making mutant animals spliced with humans is crazy, then - ! Uh. Hmm. Oh, never mind.

* On ''WesternAnimation/{{Spliced}}'', almost all of the characters are the creations of "some crazy doctor" based on [[Literature/TheIslandOfDoctorMoreau Dr. Moreau]], who was arrested prior to the series by authorities disgusted with the freaks of nature he created.

* ''WesternAnimation/{{Archer}}'': Doctor Krieger. Some of his creations include "Fister Roboto", a fully intergrated [[{{Sexbot}} multi-fetish artificial being]], an [[NuclearMutant irradiated]] pig named Pigley III, who eats people, he was responsible for [[WeCanRebuildHim rebuilding]] Russian agent Katya Kazanova into a {{Cyborg}} and built Ray Gillette his [[ArtificialLimbs robot arm.]]

* ''WesternAnimation/CaptainPlanetAndThePlaneteers'': Dr. Barbara "Babs" Blight is an insane, yet brilliant scientist, and represents unethical scientific research and technology in the wrong hands. Though sometimes, she simply causes environmental damage [[ForTheEvulz for the sake of doing so]].
** Some of her plans have a FreudianExcuse related to her [[GoodScarsEvilScars facial scar]], which can actually make her UnintentionallySympathetic to some viewers. It's a pity that the only character in the show who ''had'' healing powers – [[MotherNature Gaia]], that is – was the one Blight would ''never'' be willing to ask for help. Instead, she has tried to kill or at least harm the Spirit of Earth quite a few times.

** A much earlier example is Dr. XXX, the title character of the 1933 short, ''The Mad Doctor'', who kidnapped Mickey's dog Pluto with the intent of putting the dog's head on the body of a chicken.

* ''WesternAnimation/COPSAnimatedSeries'': Dr. Badvibes is the GadgeteerGenius of Big Boss' criminal organization.

* Dr. Thadeus "Rusty" Venture on ''WesternAnimation/TheVentureBrothers'', although his lack of ambitions and laziness mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb ([[strike:implied]] confirmed, as part of his backstory)

* The Dark Knight always seemed to be neck-deep in mad scientists on ''WesternAnimation/BatmanTheAnimatedSeries''. Within the first five episodes of the show, he runs afoul of Man-Bat, the Scarecrow, and Poison Ivy, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who [[TheyCalledMeMad called his sanity into question]]... which should answer the question of his sanity quite comprehensively.
* Tarantulus of ''Transformers: WesternAnimation/BeastWars'' is, if not a mad inventor, certainly crazy enough and scientific enough and treacherous enough to qualify for MadScientist.
** This is actually a case of CharacterDevelopment; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat ''[[ImAHumanitarian anything]]'' he can catch". This was AdaptationDisplacement--in the original toyline, he was a (still cannibalistic) ''ninja warrior''.

* ''WesternAnimation/TransformersAnimated'' has Prometheus Black. He started out messing around with biochemical enhancements to try and beat out Professor Sumdac's robotics industry, but after a lab accident changed him into the supervillain Meltdown he went into full vengeful mad science mode. The chemical warfare specialist Oil Slick might also count, although outside the fact that he's a ninja who developed the Transformer equivalent of ebola not much is known about him.
** Animated! Blackarachnia also has elements of this. The [[AllThereInTheManual Allspark Almanac]] reveals she invented triple-changing, and her attempts to better understand her techno-organic mutation lead her to try and create another hybrid...resulting in [[FromNobodyToNightmare Waspinator]].
* Wheeljack of ''Franchise/TransformersGeneration1'' is one. Part of his appeal was him convincing the other Autobots that his crackpot inventions were worth something.
** His ''[[ComicBook/TransformersShatteredGlass Shattered Glass]]'' counterpart is also a mad scientist, but less the cheery genial type normal Wheeljack is, and much, much more pure distilled ranting TheyCalledMeMad type of mad scientist.
** Dr. Arkeville from the G1 cartoon. Though his madness was one upped by Starscream himself in Countdown to Extinction.

* ''WesternAnimation/AdventureTime'': Princess Bubblegum is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and peace-loving, she has accidentally unleashed a zombie plague twice, created a number of artificial life-forms (including all the citizens of the Candy Kingdom, a giant immortal candy sphinx named Goliad who almost destroyed the kingdom, and the tyrannical, emotionally-unstable Earl of Lemongrab), has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts imprisoned on spurious charges just because she was mad about him compulsively eating her pudding stash, and was prepared to torture the Ice King in order to get a cure for the outbreak of "freezer-burn flu" he accidentally unleashed. Her "For SCIENCE!" attitude, and her devotion to protecting her kingdom, cause... interesting things to happen. Assuming that he was the one who designed and built the [[ElectricTorture Reconditioning Chamber]] and the [[CoolSword Sound Sword]], then [[TheMentallyDisturbed Lemongrab]] definitely qualifies.

* ''WesternAnimation/InvaderZim'': The title character is a mad scientist himself. In fact, in a script for an incomplete StartOfDarkness episode about him, Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.

* ''WesternAnimation/TheLegendOfKorra'': Varrick, although he's less cacklingly crazy and evil and more quirky and amoral.

** Dr. Doofenshmirtz is an AffablyEvil PunchClockVillain trying to conquer the [[WhereTheHellIsSpringfield Tri-State Area]]. He insists on being called an ''evil'' scientist, considering "mad scientist" a slur. His alter ego from the 2nd dimension was one, but now serves as the dictator.

* Rick Sanchez from ''WesternAnimation/RickAndMorty'' is as mad as they come, though he replaces the usual creepiness and cackle-happy lunacy with heaps and heaps of apathy for everything and everyone else (except maybe his grandchildren [[MoralityPet Morty]] and [[OnlySaneMan Summer]] and his daughter [[MadScientistsBeautifulDaughter Beth]]). He's someone who gives absolutely zero fucks about [[spoiler:leaving his entire dimension to die, and fleeing into another where his counterpart had died half a minute ago, burying him in the back yard and taking over his life]], and that makes him just as crazy as the cackling lunatic the trope usually conjures.

* Plankton from ''WesternAnimation/SpongeBobSquarePants'' shows signs of being this.

* The Dark Knight always seemed to be neck-deep in mad scientists on ''WesternAnimation/BatmanTheAnimatedSeries''. Within the first five episodes of the show, he runs afoul of Man-Bat, ComicBook/TheScarecrow, and {{ComicBook/Poison Ivy}}, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who [[TheyCalledMeMad called his sanity into question]]. Which should answer the question of his sanity quite comprehensively.

* Dr. Barbara "Babs" Blight on ''WesternAnimation/CaptainPlanetAndThePlaneteers'' is mad. She is an insane, yet brilliant scientist, and represents unethical scientific research and technology in the wrong hands. Though sometimes, she simply causes environmental damage [[ForTheEvulz for the sake of doing so]].
** Some of her plans have a FreudianExcuse related to her [[GoodScarsEvilScars facial scar]], which can actually make her UnintentionallySympathetic to some viewers.
*** It's all but stated that her insanity is the result of brain damage from the accident that scarred her. It's a pity that the only character in the show who had healing powers ([[MotherNature Gaia]], that is) was the one Blight would ''never'' be willing to go to for help. Just remember the times when she tried to kill or at least harm the Spirit of Earth.

* ''WesternAnimation/AdventureTime'': Princess Bubblegum is the sweet, benevolent ruler of the Candy Kingdom, but is also a highly intelligent scientist. Although normally level-headed and innocently sweet, she has created two zombie plagues, created a giant immortal candy sphinx who almost destroyed the kingdom, created a screaming nutcase who threatened her with his own sword, has skeletons chained to her walls, created a potion that can permanently paralyze someone, killed a jellyfish to make a sandwich, tried to have the Duke of Nuts killed, and tortured the Ice King. Her "For SCIENCE!" attitude, and her devotion to the law, cause... interesting things to happen. Assuming that he was the one who designed and built the [[ElectricTorture Reconditioning Chamber]] and the [[CoolSword Sound Sword]], then [[TheMentallyDisturbed Lemongrab]] definitely qualifies.

%%* ''WesternAnimation/CloneHigh'': Dr. Cinnamon J. Scudworth certainly qualifies, even though his day job is as a high school principal.%%How?

* The first ''[[WesternAnimation/SupermanTheatricalCartoons Superman]]'' short, "The Mad Scientist," has one as the villain, threatening to enact vengeance on all those who laughed at him with his electrothanasia-ray.

* ''WesternAnimation/{{Archer}}'': Doctor Krieger. Some of his creations include "Fister Roboto", a fully intergrated [[{{Sexbot}} multi-fetish artificial being]], an [[ILoveNuclearPower irradiated]] pig named Pigley III, who eats people, he was responsible for [[WeCanRebuildHim rebuilding]] Russian agent Katya Kazanova into a {{Cyborg}} and built Ray Gillette his [[ArtificialLimbs robot arm.]]

* ''WesternAnimation/TheWackyAdventuresOfRonaldMcdonald'': The main villain of "Birthday World" is an evil scientist named Professor Thaddeus J. Pinchworm, who takes advantage of Hamburglar's guilt at not getting Ronald a present by inviting the gang to a theme park as a front for using Ronald and his friends as guinea pigs for his Babe-O-Matic Ray, which he intends to use to turn everyone else on the planet into babies so he could therefore rule the world on the basis of being the only remaining adult.

%%* Nathan from ''WesternAnimation/TheGarfieldShow''.

* ''WesternAnimation/ThePowerpuffGirls'':
** Mojo Jojo, complete with evil laugh. Also, he's a monkey.

** Dr. Arkeville from the G1 cartoon. Though his madness was [[UpToEleven one upped]] by Starscream himself in Countdown to Extinction.

** In ''WesternAnimation/BatmanBeyondReturnOfTheJoker'', ComicBook/TheJoker claims to be one. FridgeBrilliance if you think that he must have been created Joker Venom from common chemicals:
-->'''Joker:''' ''Beneath this puckish exterior lies the mind of a genius years ahead of my time. [[spoiler:In the weeks young [[ComicBook/RedRobin Robin]] [[BreakTheCutie was under]] [[WouldHurtAChild my tutelage]], I used him as the subject of my greatest experiment.]] Using cutting-edge genetics technology which I pinched here and there, I encoded my DNA in a microchip and [[spoiler:set it in Bird Boy's birdbrain.]]''

** Mrs. Driscoll's husband Jerry Driscoll, back when he was alive. In fact, he was in the same class as Viceroy at MSU and his primary rival for valedictorian. Viceroy got him arrested in order to take him out of the competition, and he died not long after. When he's briefly revived by Randy in "Dawn of the Driscoll", he tries to complete the "destroy the world" doomsday device he was building in college in order to become valedictorian of his class, completely unaware of how much time had passed since his death. He only gives up after he finds out the truth from Mrs. Driscoll. [[spoiler:And then claims it's time to get started on his "destroy the ''universe''" doomsday device. [[EveryoneHasStandards It's at that point that Mrs. Driscoll requests Randy turn him back to normal]]]].

** Singed, a chemist, is the brains behind Silco's unethical experiments.
** [[MadBomber Jinx]] is an engineer who uses scraps she could find to build her weapons and recreate Jayce's first Hextech experiment while understanding the underlying principles from reading his notes.

** This is actually a case of CharacterDevelopment; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat ''[[ImAHumanitarian anything]]'' he can catch". This was AdaptationDisplacement--in the original toylines, he was a (still cannibalistic) ''ninja warrior''.

* ''WesternAnimation/InsideJob'':

** VillainProtagonist Reagan is a GadgeteerGenius working as a team leader for an EvilInc run by TheIlluminati to help administrate their control over the free world. She's more on the AffablyEvil side of the spectrum, but her CloudCuckoolander tendencies and [[NoSocialSkills lack of social skills]] have resulted in a mountain of HR complaints about actions such as terrorizing her coworkers with a {{mecha}} for forgetting to fill out their time cards.