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!!Female Examples
* ''Series/BuffyTheVampireSlayer'':
** Drusilla is frail and weak when she first appears on the series. She was believed to have been killed by a mob in Prague, but apparently was only severely injured (How that mistake happens with a creature that turns to ''dust'' when killed is anyone's guess), to the point that normal vampiric healing couldn't restore her. Spike manages to restore her to full health by draining power off of Angel.
** Darla was a HighClassCallGirl suffering from syphilys and waiting for her death. Then the Master gave her a visit....
* ''Series/{{Charmed}}'': The episode "Awakened" revolves around Prue and Phoebe discovering that Piper is terminally ill with the disease Oroya Fever. While real life symptoms of Oroya Fever include being covered in warts and rashes, Piper only experiences coughing, exhaustion, and fainting, all done adorably. [[spoiler: Being the main character, Piper survives, but not until after the crying and good-byes.]]
* Many, MANY of these show up in {{Soap Opera}}s, specially Latin-American Telenovelas:
** The titular ''[[http://en.wikipedia.org/wiki/Esmeralda_(telenovela) Esmeralda]]'' was born blind. This is later revealed to be due to congenital cataracts and she successfully regains her sight after an operation. Her personality switches from [[TheIngenue sweet and gentle]] while blind to [[BrokenBird tough, stubborn and unforgiving]] almost overnight.
** The female lead from the Chilean telenovela ''Corazón de María'' is an [[{{Ojou}} upper class]] Ill Girl with a severe HeartTrauma. She gets a heart transplant coming from a middle-to-low class bride killed in a tragic car accident ''right after her wedding''. The drama starts when she starts searching for the donor María's family [[BecauseYouWereNiceToMe to thank them for the heart donation]], and then she meets [[UptownGirl and falls for]] her handsome and hard-working husband Miguel...
** Alicia, a cute young girl in a wheelchair from ''Series/MariaLaDelBarrio'', doubles as a DisabledLoveInterest for a certain boy named Nandito. The scene where the BigBad [[LargeHam Soraya]] threatens poor Alicia for kissing Nandito while screaming "MALDITA LISIADA!" ("Goddamned crippled bitch!") and then throws her off her wheelchair is so [[{{Narm}} ridiculous and overacted]] that it has reached MemeticMutation levels.
* ''Series/KyleXY'', [[GenderBlenderName Andy]] is sick with cancer.
* ''Series/{{LOST}}'':
** Shannon (Maggie Grace) is asthmatic and needs to have an inhalator handy. Sawyer once stole her medicine and tried to use it to bargain.
** Juliet's sister is an Ill Girl whose cancer and resulting infertility is what drove Juliet to do some rather... illegal things as a fertility doctor. When Juliet goes to the island, she is afraid to leave her sister alone, but, with typical ill girl sweetness, her sister convinces her to go.
* ''Series/{{Merlin}}'': Happens frequently with Morgana, most notably in ''A Remedy To Cure All Ills'' in which the MonsterOfTheWeek deliberately makes her sick in order to heal her and so win King Uther's trust.
* ''Series/OneLiterOfTears'':
** Aya Ikeuchi, the protagonist, is a highschool girl diagnosed with [[https://en.wikipedia.org/wiki/Spinocerebellar_ataxia Spinocerebellar Degeneration Disease]]. Slowly she's robbed of her ability to walk, talk, or eat and even daily mundane tasks are a challenge for her, [[ForegoneConclusion until she dies.]] What's sadder is that it doesn't affect the mind at all, meaning [[AndIMustScream she can see just how helpless she's becoming...]]
** When Aya is sent to a special school, she shares a room with a girl named Asami Oikawa who has exactly the same illness.
** In the TV special that serves as an epilogue, Aya's love interest Haruto has become a doctor and one of his patients is a girl named Mizuki Nagashima, who has Aya's same illness and has lost the will to live. Haruto and Aya's sister Ako, who's now a nurse, decide to help her as much as they can.
* ''TheTudors'': Jane Seymour, another case of TruthInTelevision considering how she died.
* ''Series/TheXFiles'': Scully takes on this role for one season after it is revealed that [[spoiler: the tests preformed on her during her abduction have left her with (probably terminal) cancer.]] In accordance with the conventions of the trope, her appearance is relatively unaffected by the illness, and the only visible symptom is a [[spoiler: ''{{Deadly Nosebleed}}''.]]
* In ''Series/HowIMetYourMother'', [[spoiler:The Mother becomes one]] during the course of the finale, and we see her in a hospital bed for a few seconds. In the end, [[spoiler:she dies of her (unspecified) illness, leaving Ted to go back to Robin 25 years after meeting her]].
* One of the "Lost Loves" cases from Series/UnsolvedMysteries dealed with two little girls in a cancer ward, one with throat cancer and another with ovarian cancer. The two became fast friends, and the first one promised that she'd make the other girl the godmother of her firstborn to help her deal with how she wouldn't be able to have children. 20-something years later, the first girl was still searching for her friend... [[spoiler: And a later episode revealed [[HeartwarmingMoments that she eventually found her]].]]
* Hester from the Fox series ''Series/ScreamQueens2015'', a sorority pledge with scoliosis who earned the nickname "Neckbrace".
* Brona from ''Series/PennyDreadful'' suffers from Tuberculosis [[spoiler: which kills her at the end of Season 1 to set her up as Frankenstein's Bride]]. Unlike some ill girls who become ThePollyanna, she is absolutely ''furious'' about her condition but refuses to let it be her defining characteristic.
* In ''Series/{{House}}'', Remy "Thirteen" Hadley has Huntington's Disease, inherited from her mother. While the full brunt of the disease doesn't rear its ugly head during the series, it does endanger her life in one episode when she is forced to take medications that are dangerous to her with her disease by a man holding hostages and trying to find a diagnosis.
* Mary of ''SecondChance2016'' is terminally ill with cancer (or implied to be, as she mentioned that her chemo stopped working). However, because of her [[AmbiguousDisorder mentally-off]] brother, Otto, she goes so far as to revive and clone a person to fight her cancer.
* The LittlestCancerPatient from the ''Series/LawAndOrderSpecialVictimsUnit'' episode "Sick," who is dying of leukemia. [[spoiler: It's then revealed that she's actually dying of mercury poisoning--and her ''grandmother'' is responsible, simply so she can [[MunchausenSyndrome get sympathy from everyone else]].]]
* ''Series/{{Oshin}}'' has two:
** When Oshin is a teenager, her older sister Haru catches tuberculosis thanks to her workplace's very unsafe work conditions and is sent back home. [[spoiler: She dies of it, entrusting Oshin with her TragicDream of becoming a hair stylist.]]
** Oshin's best friend Kayo has a rather delicate little sister named Sayo, [[spoiler: who dies of pneumonia. Oshin searches for Kayo, who has been missing for two years already after [[RunawayBride escaping from]] an ArrangedMarriage, to tell her about Sayo's demise and convince her to return home.]]

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!!Male Examples
* ''Film/{{Hawking}}'': Portrays the twenty one year old Stephen Hawking as more of a very smart IllBoy than a GeniusCripple, unlike conventional depictions of Hawking as an older man.
* ''Jappening con Ja'': In this Chilean humor show, there was a sketch named "El Enfermito" ("The Ill Dude"). It had [[NoNameGiven an unnamed adult man]] permanently bedridden and hospitalised due to an unexplained SoapOperaDisease, and HilarityEnsues ([[CringeComedy in a way]]) whenever his friends drop by to visit him. [[NotFunnyAnymore It's not as funny now]] due to the ''actor's'' own health taking massive hits through the years, which eventually killed him.
* ''Series/BreakingBad'' 's Walter White has lung cancer which slowly kills him throughout the series. In order to support his family and pay for medicine, he goes into the drug trade, using his knowledge as a chemistry teacher to make crystal meth.
* ''Series/KamenRiderFourze'': Kengo suffers from an unspecified weakness that rendered him unable to use the Fourze system as well as the [[MiniMecha Power Dizer]]; he's actually been nicknamed "King of the Infirmary" due to the amount of time he's spent there (even when he's ''not'' just using it [[PlayingSick as an excuse]] to help fight the MonsterOfTheWeek). [[spoiler:The Aquarius Zodiarts uses her healing powers to cure him about 2/3 of the way through the series.]] [[spoiler: This is later jossed in episode 45, when his illness/weakness comes back full force.]]
* ''Series/KamenRiderRyuki'': Kitaoka Shuichi, even though he's quite a bit older than the usual victim of this trope.
* ''Series/MiraiSentaiTimeranger'': Ayase / TimeBlue suffered from the incurable Osiris Syndrome throughout the entire series. [[spoiler:However, after time has been altered near the finale, a cure for his disease is found.]]
* ''Series/{{Revolution}}'':
** Danny's asthma causes some characters to perceive him as weak - to this day Charlie is constantly worrying about him and trying to keep her promise to watch over him. Justified given that this is a lawless, unforgiving CrapsackWorld and other than plant-based medicines there's not a lot that can restore his breathing if he has an attack. In "[[Recap/RevolutionS1E3NoQuarter No Quarter]]", Danny also uses this to his advantage, to get the drop on the mook Private Richards who's been harassing him.
** "[[Recap/RevolutionS1E17TheLongestDay The Longest Day]]" has Aaron Pittman and Rachel Matheson meet Philip Blackmore, who has been dying of injuries ever since he fell off a horse. [[spoiler: Rachel decides to lead the Blackmores into believing that they can save their son, and then just take off with Aaron and let Philip die]].
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!!Mixed Examples
* ''Series/{{Firefly}}'':
** Perfect example found in the story of [[TheWoobie River Tam]], a young girl who is a [[AxCrazy schizophrenic]] [[TheEmpath empath]] as a result of [[MindRape extensive neurological modification/experimentation]] done to her by a shadowy, government-affiliated military research facility. Her older brother, [[TheMedic Simon]], [[BigBrotherInstinct gives up his life as a successful doctor and makes them both federal fugitives when he breaks her out of captivity. The siblings are forced to live on the outskirts of society in order to avoid capture, and Simon spends much of his time and resources in his efforts to find a treatment to help restore River to her former self.]]
** In true Ill Girl fashion, it is also implied that there's no ''real'' possibility for River to ever be cured of her insanity; the best that can be done is short-term chemical treatments, as the damage to her brain is extensive and her body eventually rejects any drugs used to help her. Even after the events of TheMovie, its not made clear whether she's fully healed or has only partially recovered.
** [[WordOfGod revealed]] adds [[spoiler:Inara Serra, resident [[HookerWithAHeartOfGold Oiran]].]]
** Jayne Cobb faithfully sends money home to treat his ill brother Mattie's damp lung disease.
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