!!Male Examples
* In the ''WesternAnimation/AvatarTheLastAirbender'' fanfic ''[[http://www.fanfiction.net/s/6245901/1/Three_Years_At_Sea Three Years At Sea,]]'' Zuko was "sickly" for most of his childhood, making him appear even weaker in comparison to Azula in his father's eyes.
* Lance Wabisuke-Hamilton from ''Fanfic/OnePieceParallelWorks'' has a mysterious illness that causes him to fall asleep at random times and makes him physically weak. However, {{Word of God}} states that Lance's condition is not life-threatening.
* Tim in ''[[http://www.fimfiction.net/story/29758/his-own-personal-heaven His Own Personal Heaven]]'' was diagnosed with colitis and fell out of touch with all his friends. He could only find consolation in fantasizing about himself with [[WesternAnimation/MyLittlePonyFriendshipIsMagic six colorful mares.]]
* Paul in the Pokemon fanfic Fanfic/TravelsOfTheTrifecta (yes, [[JerkAss THAT]] [[StopHavingFunGuys Paul]]) spends chapters 3 to 7 suffering from a severe cold/flu and later begins to cough up blood periodically. [[spoiler: This is a sign that he has inherited the terminal illness that his mother died from.]]

!!Female Examples:
* In the VideoGame/TouhouProject fanfiction ''[[http://www.fanfiction.net/s/9522160/1/Reimu-s-Illness Reimu's Illness]]'', because of her unstable (it is described as being up and down) health, Reimu falls ill with tuberculosis, human enterovirus 68, and viral meningitis and she is so sick that she's had to be transferred to a hospital in the city and be placed in something called an isolation box (which is akin to an incubator for premature infants).
** In [[http://www.fanfiction.net/s/9354387/1/Gensokyo-20XX-Rise-Of-Earth-full-Version Gensokyo 20XX]], she has been plagued with colds, depression, and various other ailments, even lack of sleep and appetite, requiring her to take so many medications to no avail. Ultimately, she was hospitalized and the doctors did all they really could.
** In 20XXI, Eirin, due to stress, was starting to become this, developing some anemic condition as a result of stress, but she commits suicide before it becomes an issue
** In 20XXII, Keine is revealed to have died of an illness consisting of "pneumonia and lumps in her lungs", Aya dies of heart-attack caused by illness and stress, and Koishi started to become this.
** In 20XXIII and later on 20XXIV, after the nukes are dropped, Sakuya dies of radiation sickness.
** In 20XXIV, Reimu's mother, Reiko, dies of a long term illness. Earlier, she was ill with radiation sickness before it dissipated.
*** Reimu (post age-regression) becomes this once again in Gensokyo 20XXV, after living in The Forbiddens for some time, and it was noted that she has been sick off and on.
** From 20XXV, we have Yume Ni, in the aftermath of Chen's TheReasonYouSuckSpeech. From what is said, she has a chronic illness and later on passed away. Later one, we have Ran, although, unlike the aforementioned Yume Ni, her illness isn't terminal, although it is hindering
* From Webcomic/KillLaKillAU, we have Satsuki, as a result of stress taking a toll on her health. The first time is when she had appendicitis and the second time is when she has [[spoiler: Tuberculosis]]. Later, in comic 41, we have this Ryuuko, after she makes a wish to be the sick one instead of Sats. This is also the subject of a more recent fanfiction where Ryuuko becomes ill and has to be hospitalized for tests. Although, as of chapter 9, it was revealed she had some unknown illness, which turned into septicemia, the which would have and probably could have killed her.
* Ruby Rose in the RWBY Henceforward AU was stabbed straight through her spine with Blake Belladonna's Gambol Shroud. Though she narrowly avoids death and paralysis, this inhibits her physical capabilities to an extreme degree. Her reflexes are dulled, she can only lift half her body weight, and she must avoid any more physical trauma if for fear of the damage worsening. This keeps her from achieving her dream of becoming an official huntress and forces her to heavily redesign her weapon and fighting style to manage any sort of combat effectiveness. Funnily enough, though, is she probably worries about her condition the least and still makes a few reckless moves similar to those she would make in her youth (though she has attained a new sort of eerie grace in her fighting that she never had before). Her partner and possible lover, Weiss Schnee, is the one constantly keeping note of Ruby's condition and doing everything she can to make sure Ruby keeps from overdoing it.
* [[OriginalCharacter Stella]] [[SelfInsert Squalo]] from the KHR fanfic [[https://www.fanfiction.net/s/9161560/1/Polaris Polaris]] is an example of this. She has some unspecified disease that breaks her body down gradually from birth, and she uses Mist Flame illusions for most of her life to keep her body from failing. When she does die, and the illusion breaks, her body is a rotting corpse with maggots in her flesh and exposed bone.
* From one Anime/KillLaKill fic, titled ''[[https://www.fanfiction.net/s/11037352/1/%E9%A3%9B%E9%B3%A5-Asuka Asuka]]'', we have this with either Satsuki or Ryuuko (it's never made clear which), who was diagnosed with something that is described to be "chronic sans cure" and [[spoiler: she succumbs to her illness in the end]]