- Cheryl Blossom in Archie Comics, according to recent issues. She has cancer.
- Illyana Rasputin aka Magik in X-Men. More exactly, she falls victim to the Legacy Virus, which makes her Colossus's dead little sister. For a while anyway. It's... complicated.
- Buns Rabbot, the Mirror Universe Evil Twin of Bunnie D'Coolette-Rabbot in Archie Comics' Sonic the Hedgehog, has N.I.D.S., the same disease that Maria Robotnik had. To save her life, Ivo Kintobor placed her in the Omega Care Unit, the Mirror Universe version of E-123 "Omega".
- Lisa Moore of Funky Winkerbean and her cancer. To the point where readers of the strip have constantly mocked the comic because of its over-reliance on it.
- Betty Ross once got cancer after being poisoned by the Abomination.
- James Howlette aka Wolverine was this as a boy, due to poor Victorain era medicine and Logan's own trouble with his mutant powers and was bedridden as result. After running away after killing his father, Logan's sickness wore off and his Healing Factor made any possible diseases he could get almost non-existent and made him near immortal. Ironic considering how weakly he was starting off.
- Abraham Kieros was a Vietnam War veteran who ended up horribly crippled and abandoned in an hospital. Then, he takes a Deal with the Devil from Apocalypse and becomes his follower, War I. After the group is disbanded, Kieros is again paralyzed, but later he was healed by his ex-fellow Horseman Archangel.
- NYX: Bobby Soul aka Felon's little brother, Lil' Bro, is severely autistic, and he has been using his powers for shady jobs to raise the money to get him out of District X and into a school where he can receive the care he needs. The only reason Felon takes on Zebra Daddy's job to track down a runaway prostitute is because Daddy offers to not only pay him the rest of what he needs, but a substantial additional bonus. The sequel suggested that Lil' Bro was not actually autistic, but had become catatonic as a result of severe sexual abuse by their mother's boyfriend, which is also why Bobby was raising the little guy on his own — he'd completely lost trust in their mother.
- The Death of Clark Kent: Downplayed with Conduit, aka Kenny Braverman. He was irradiated by Kryptonite when Clark's shuttle flew over his pregnant mother. His frequent bouts of poor health prevented him from excelling to quite the same degree as Clark.