When Aggie gets in trouble with the principal for commandeering the P.A. system to announce her candidacy for student council president, she asks her father whether he's angry with her. Nick's affectionately ironic response: "Standing up to authority for principle, trying to reach the kids who think like you...Your mother and I are furious."
The title characters putting aside their rivalry to stop the bullying by Karen and her clique. A particularly powerful moment, as it came at the end of the comic's most gut-wrenching chapter up to that point, with both characters at their lowest ebb.
Penny: Ready to save the world, you post-ironic post-yuppie?
Also their moving from allies to genuine friends in thesestrips.