Literally, the show is about a dog and a squirrel being best friends.
- Mrs. Fluffée has a crush on Ed, so this may count.
- Buddy realizing spending the rest of his life without fur is better than spending the rest of his life without Ed.
http://tvtropes.org/pmwiki/pmwiki.php/Heartwarming/BestEd
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Literally, the show is about a dog and a squirrel being best friends.