* Many of the conversations [=ToeJam=] and Earl have in the elevator.
-->'''[=ToeJam=]:''' Move over, Earl. ({{beat}}) No, the other way!!\\\
'''Earl:''' It's dark. I'm scared.\\
'''[=ToeJam=]:''' Get a clue, Earl!\\\
'''[=ToeJam=]:''' Stop writing on the walls.\\
'''Earl:''' OK, I'm sorry.\\\
'''[=ToeJam=]:''' What's that smell?\\
'''Earl:''' Wasn't me.\\\
'''Earl:''' Oops!\\
'''[=ToeJam=]:''' Oh, get a belt, Earl!\\\
'''Earl:''' [[WhatDoesThisButtonDo What does this button do?]]\\
'''[=ToeJam=]:''' [[SayMyName EARL!!!]]
* The crazed shopper screaming "SHUT UP!!" to her child.
* If both characters are on the screen and one [[SneezeOfDoom sneezes]], the other will say "Gesundheit."
* If [=ToeJam=] gets hit with Cupid's arrow, he will in a two-player game [[HoYay confess his love to Earl]].
* Anytime a Chicken Infantry kills another Earthling.
* Some of the Earthlings' dances when you use the boombox present. The Boogeyman, the Wise Carrot, the Wizard and the Mole are honorable mentions.
* [[spoiler: After you beat the game playing as [=ToeJam=] and Earl.]]
-->[[spoiler: '''Earl:''' Can I drive?]]\\
[[spoiler: '''[=ToeJam=]:''' [[BigNo No!]]]]
* [[spoiler: At the end, one of the Funkotronians says "Hey, where's my money??"]]
** [[spoiler: Another tells Earl to get a belt.]]
* Pleading with the Funkopotamus to come out in the sequel.
-->"Please?" "No." '''[repeats fifteen times]'''
* Earl attempting to look as smooth as possible in the intro while [=ToeJam=] explains that the only reason they're stranded on Earth is because Earl is a terrible driver.
--> '''Earl:''' Problem :D
* In the third game, one of the voice bytes the cheerleader says is: "My mom says she thinks you're my daddy and you owe us some money."
* If it's not happening in a lethal situation, some the reactions the playable characters have to getting hurt are pretty funny:
** Getting kicked in the shins by the little girl debuting in the second game.
** Stunned and seeing spots from the photographer's flash in the second game.