!!! ''Astro Boy'' (2009 film)

* Astro's stunned reaction to the first time his rocket boots fire, including a hilarious expression and a wonderfully prompt (and pretty harsh) slap to his own face.
** And then as shock becomes delight he tries to zip off heroically - only to briefly ''forget how to power the jets'' and, on reactivating them, slam himself backwards into a building and then straight up through its stone facade.
* A soldier trying to use windshield wipers when Astro crashes into his ship. Astro's look of sheer annoyance is priceless.
* Trash Can the robot dog's [[spoiler:final attempt to "out" Toby as a robot, spelling out on the ground in huge letters "HE'S A ROBOT!" with an arrow pointing to Astro/Toby to Zane. Made funnier when Zane shrugs, "Almost makes me wish I could read!"]]
* When the RRF 'rescue' Astro.
--> '''Cora''': What just happened?
* "Hey! I'm voting for the other guy!"
* When Astro discovers his "accessories".
--> '''Astro''': What? I got ''machine guns?'' In my ''butt?!''
** And the first use of his {{Arm Cannon}}s: "Hah! Cool!" ''*blam!*'' [goes flying backwards]
* When Astro saves one of the guy's after him, and then has to deal with the reinforcements.
--> '''Astro''': What's with you guys?
--> '''Guard''': I love you!
* Any scene involving the Robot Revolutionary Front.
* The President as the GiantMecha. Everything out of his mouth is pure hilarious DeadpanSnarker.

!!! '''2003 series'''
* From the first episode, the Inspector asks Dr. O'Shay about the blackout caused by reviving Astro. His explanation? "I can't sleep with the lights on."
* Anytime someone bangs down Tenma's door. Made better by his sheer calmness about it.
--> '''Tenma''': ''(surrounded by police)'' So many visitors. And I didn't even make tea.
* Some of Tenma's creeper moments qualify as well.
--> '''Tenma''': ''(disturbing grin)'' Always a pleasure.
--> '''Astro''': You're creepy.
* Astro Boy continues to sass Dr. Tenma
--> '''Astro''': ''(on Tenma's StalkerWithoutACrush tendencies)'' Don't you have anything better to do?

!!! '''Original Manga'''
* [[http://27.media.tumblr.com/tumblr_lpyd60voS11qinrdfo1_500.jpg This]] moment from the "Astro Reborn" arc.
* There's a scene in one volume where Astro's school friends try to rescue him from a villain in what's generally a CrowningMomentOfAwesome, but at one point their choice of taunt to the villain just comes off as hilarious for some reason: "We're going to cut off [[BeardOfEvil your beard]] and throw it in the garbage can!"
* In Hamegg's robot circus, someone asks Astro to point out the good and bad people in the room. He immediately declares Hamegg the worst of all.